| Full name: steroid 5 alpha-reductase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5p15.31 | ||
| Entrez ID: 6715 | HGNC ID: HGNC:11284 | Ensembl Gene: ENSG00000145545 | OMIM ID: 184753 |
| Drug and gene relationship at DGIdb | |||
Expression of SRD5A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRD5A1 | 6715 | 204675_at | -0.3057 | 0.6736 | |
| GSE20347 | SRD5A1 | 6715 | 204675_at | -1.0430 | 0.0002 | |
| GSE23400 | SRD5A1 | 6715 | 211056_s_at | -0.1883 | 0.0940 | |
| GSE26886 | SRD5A1 | 6715 | 204675_at | -0.8409 | 0.0002 | |
| GSE29001 | SRD5A1 | 6715 | 204675_at | -0.3735 | 0.4001 | |
| GSE38129 | SRD5A1 | 6715 | 204675_at | 0.0267 | 0.9581 | |
| GSE45670 | SRD5A1 | 6715 | 204675_at | -0.0618 | 0.8110 | |
| GSE53622 | SRD5A1 | 6715 | 53764 | -0.3267 | 0.0556 | |
| GSE53624 | SRD5A1 | 6715 | 53764 | -0.3764 | 0.0004 | |
| GSE63941 | SRD5A1 | 6715 | 204675_at | 1.0616 | 0.1242 | |
| GSE77861 | SRD5A1 | 6715 | 204675_at | -1.2777 | 0.0368 | |
| GSE97050 | SRD5A1 | 6715 | A_23_P30223 | 0.8594 | 0.2285 | |
| SRP007169 | SRD5A1 | 6715 | RNAseq | -0.7176 | 0.0972 | |
| SRP008496 | SRD5A1 | 6715 | RNAseq | -0.7646 | 0.0050 | |
| SRP064894 | SRD5A1 | 6715 | RNAseq | -0.8095 | 0.0011 | |
| SRP133303 | SRD5A1 | 6715 | RNAseq | 0.0267 | 0.8524 | |
| SRP159526 | SRD5A1 | 6715 | RNAseq | -0.8784 | 0.0000 | |
| SRP193095 | SRD5A1 | 6715 | RNAseq | -0.0590 | 0.6885 | |
| SRP219564 | SRD5A1 | 6715 | RNAseq | -0.6181 | 0.3348 | |
| TCGA | SRD5A1 | 6715 | RNAseq | 0.6076 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SRD5A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRD5A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRD5A1 | 6715 | 13 | 0 | 17 | |
| GSE20123 | SRD5A1 | 6715 | 13 | 1 | 16 | |
| GSE43470 | SRD5A1 | 6715 | 16 | 0 | 27 | |
| GSE46452 | SRD5A1 | 6715 | 6 | 22 | 31 | |
| GSE47630 | SRD5A1 | 6715 | 6 | 11 | 23 | |
| GSE54993 | SRD5A1 | 6715 | 5 | 5 | 60 | |
| GSE54994 | SRD5A1 | 6715 | 29 | 1 | 23 | |
| GSE60625 | SRD5A1 | 6715 | 0 | 0 | 11 | |
| GSE74703 | SRD5A1 | 6715 | 12 | 0 | 24 | |
| GSE74704 | SRD5A1 | 6715 | 11 | 0 | 9 | |
| TCGA | SRD5A1 | 6715 | 57 | 4 | 35 |
Total number of gains: 168; Total number of losses: 44; Total Number of normals: 276.
Somatic mutations of SRD5A1:
Generating mutation plots.
Highly correlated genes for SRD5A1:
Showing top 20/693 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRD5A1 | MAP7 | 0.723387 | 4 | 0 | 4 |
| SRD5A1 | SLC10A7 | 0.718333 | 3 | 0 | 3 |
| SRD5A1 | DMKN | 0.716469 | 4 | 0 | 4 |
| SRD5A1 | CARD16 | 0.710342 | 3 | 0 | 3 |
| SRD5A1 | BNIP3 | 0.708814 | 3 | 0 | 3 |
| SRD5A1 | KCNK6 | 0.697221 | 4 | 0 | 4 |
| SRD5A1 | LDHA | 0.690606 | 3 | 0 | 3 |
| SRD5A1 | GSDMC | 0.686748 | 5 | 0 | 4 |
| SRD5A1 | PSMD6-AS2 | 0.684495 | 3 | 0 | 3 |
| SRD5A1 | PRKCZ | 0.678454 | 4 | 0 | 4 |
| SRD5A1 | SS18 | 0.673098 | 4 | 0 | 3 |
| SRD5A1 | ALDH2 | 0.670929 | 4 | 0 | 3 |
| SRD5A1 | SF3B3 | 0.668325 | 5 | 0 | 4 |
| SRD5A1 | DOCK10 | 0.663891 | 4 | 0 | 4 |
| SRD5A1 | MPZL2 | 0.661908 | 10 | 0 | 8 |
| SRD5A1 | VSNL1 | 0.660735 | 9 | 0 | 9 |
| SRD5A1 | HM13 | 0.659733 | 3 | 0 | 3 |
| SRD5A1 | AP1M2 | 0.655988 | 5 | 0 | 4 |
| SRD5A1 | HDLBP | 0.653732 | 3 | 0 | 3 |
| SRD5A1 | CELSR2 | 0.652272 | 6 | 0 | 5 |
For details and further investigation, click here
