| Full name: cholinergic receptor nicotinic beta 1 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 1140 | HGNC ID: HGNC:1961 | Ensembl Gene: ENSG00000170175 | OMIM ID: 100710 |
| Drug and gene relationship at DGIdb | |||
Expression of CHRNB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRNB1 | 1140 | 206703_at | -0.3049 | 0.4067 | |
| GSE20347 | CHRNB1 | 1140 | 206703_at | -0.0492 | 0.5617 | |
| GSE23400 | CHRNB1 | 1140 | 206703_at | 0.0561 | 0.1756 | |
| GSE26886 | CHRNB1 | 1140 | 206703_at | 0.0763 | 0.6630 | |
| GSE29001 | CHRNB1 | 1140 | 206703_at | -0.1169 | 0.3341 | |
| GSE38129 | CHRNB1 | 1140 | 206703_at | 0.0167 | 0.8706 | |
| GSE45670 | CHRNB1 | 1140 | 206703_at | -0.1765 | 0.2602 | |
| GSE53622 | CHRNB1 | 1140 | 93658 | 0.1374 | 0.2319 | |
| GSE53624 | CHRNB1 | 1140 | 93658 | 0.0953 | 0.2890 | |
| GSE63941 | CHRNB1 | 1140 | 206703_at | 0.7651 | 0.1487 | |
| GSE77861 | CHRNB1 | 1140 | 206703_at | -0.1331 | 0.0946 | |
| GSE97050 | CHRNB1 | 1140 | A_23_P207106 | 0.2029 | 0.5095 | |
| SRP007169 | CHRNB1 | 1140 | RNAseq | -0.9357 | 0.0806 | |
| SRP008496 | CHRNB1 | 1140 | RNAseq | -0.7527 | 0.0697 | |
| SRP064894 | CHRNB1 | 1140 | RNAseq | 0.2532 | 0.2070 | |
| SRP133303 | CHRNB1 | 1140 | RNAseq | -0.1709 | 0.3228 | |
| SRP159526 | CHRNB1 | 1140 | RNAseq | -0.4675 | 0.0500 | |
| SRP193095 | CHRNB1 | 1140 | RNAseq | 0.0702 | 0.5808 | |
| SRP219564 | CHRNB1 | 1140 | RNAseq | 0.2434 | 0.5805 | |
| TCGA | CHRNB1 | 1140 | RNAseq | 0.3045 | 0.0153 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHRNB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRNB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRNB1 | 1140 | 4 | 2 | 24 | |
| GSE20123 | CHRNB1 | 1140 | 4 | 3 | 23 | |
| GSE43470 | CHRNB1 | 1140 | 1 | 4 | 38 | |
| GSE46452 | CHRNB1 | 1140 | 34 | 1 | 24 | |
| GSE47630 | CHRNB1 | 1140 | 7 | 1 | 32 | |
| GSE54993 | CHRNB1 | 1140 | 4 | 3 | 63 | |
| GSE54994 | CHRNB1 | 1140 | 5 | 8 | 40 | |
| GSE60625 | CHRNB1 | 1140 | 4 | 0 | 7 | |
| GSE74703 | CHRNB1 | 1140 | 1 | 2 | 33 | |
| GSE74704 | CHRNB1 | 1140 | 2 | 1 | 17 | |
| TCGA | CHRNB1 | 1140 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 46; Total Number of normals: 359.
Somatic mutations of CHRNB1:
Generating mutation plots.
Highly correlated genes for CHRNB1:
Showing top 20/202 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRNB1 | DNASE1L1 | 0.793256 | 3 | 0 | 3 |
| CHRNB1 | UCHL3 | 0.762444 | 3 | 0 | 3 |
| CHRNB1 | MRPS27 | 0.757534 | 3 | 0 | 3 |
| CHRNB1 | LZTS1 | 0.742674 | 3 | 0 | 3 |
| CHRNB1 | VPS52 | 0.726394 | 3 | 0 | 3 |
| CHRNB1 | DHX29 | 0.722153 | 3 | 0 | 3 |
| CHRNB1 | HLA-DOA | 0.713456 | 3 | 0 | 3 |
| CHRNB1 | KCNK13 | 0.708878 | 3 | 0 | 3 |
| CHRNB1 | FBXL16 | 0.70833 | 3 | 0 | 3 |
| CHRNB1 | KIR3DS1 | 0.707789 | 3 | 0 | 3 |
| CHRNB1 | SAR1B | 0.702471 | 3 | 0 | 3 |
| CHRNB1 | ZCCHC9 | 0.700562 | 3 | 0 | 3 |
| CHRNB1 | SLC25A43 | 0.688935 | 3 | 0 | 3 |
| CHRNB1 | GSDMC | 0.68575 | 3 | 0 | 3 |
| CHRNB1 | CNR2 | 0.684613 | 3 | 0 | 3 |
| CHRNB1 | PGM2 | 0.678941 | 3 | 0 | 3 |
| CHRNB1 | GBE1 | 0.678228 | 3 | 0 | 3 |
| CHRNB1 | COMMD8 | 0.677589 | 3 | 0 | 3 |
| CHRNB1 | HUS1 | 0.677116 | 3 | 0 | 3 |
| CHRNB1 | C3orf80 | 0.6703 | 3 | 0 | 3 |
For details and further investigation, click here
