| Full name: programmed cell death 6 interacting protein | Alias Symbol: Alix|AIP1|Hp95 | ||
| Type: protein-coding gene | Cytoband: 3p22.3 | ||
| Entrez ID: 10015 | HGNC ID: HGNC:8766 | Ensembl Gene: ENSG00000170248 | OMIM ID: 608074 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PDCD6IP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDCD6IP | 10015 | 217746_s_at | -0.6599 | 0.2034 | |
| GSE20347 | PDCD6IP | 10015 | 217746_s_at | -1.3997 | 0.0000 | |
| GSE23400 | PDCD6IP | 10015 | 217746_s_at | -0.7877 | 0.0000 | |
| GSE26886 | PDCD6IP | 10015 | 217746_s_at | -1.7158 | 0.0000 | |
| GSE29001 | PDCD6IP | 10015 | 217746_s_at | -1.1394 | 0.0002 | |
| GSE38129 | PDCD6IP | 10015 | 217746_s_at | -1.0542 | 0.0000 | |
| GSE45670 | PDCD6IP | 10015 | 217746_s_at | -0.5232 | 0.0133 | |
| GSE53622 | PDCD6IP | 10015 | 134363 | -0.9659 | 0.0000 | |
| GSE53624 | PDCD6IP | 10015 | 134363 | -1.2001 | 0.0000 | |
| GSE63941 | PDCD6IP | 10015 | 217746_s_at | 0.4097 | 0.1647 | |
| GSE77861 | PDCD6IP | 10015 | 217746_s_at | -1.0747 | 0.0003 | |
| GSE97050 | PDCD6IP | 10015 | A_32_P22338 | -0.2824 | 0.3515 | |
| SRP007169 | PDCD6IP | 10015 | RNAseq | -1.9862 | 0.0000 | |
| SRP008496 | PDCD6IP | 10015 | RNAseq | -1.7773 | 0.0000 | |
| SRP064894 | PDCD6IP | 10015 | RNAseq | -1.2200 | 0.0000 | |
| SRP133303 | PDCD6IP | 10015 | RNAseq | -0.8183 | 0.0000 | |
| SRP159526 | PDCD6IP | 10015 | RNAseq | -1.4072 | 0.0000 | |
| SRP193095 | PDCD6IP | 10015 | RNAseq | -1.3816 | 0.0000 | |
| SRP219564 | PDCD6IP | 10015 | RNAseq | -1.2266 | 0.0034 | |
| TCGA | PDCD6IP | 10015 | RNAseq | -0.1630 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by PDCD6IP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDCD6IP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDCD6IP | 10015 | 0 | 18 | 12 | |
| GSE20123 | PDCD6IP | 10015 | 0 | 18 | 12 | |
| GSE43470 | PDCD6IP | 10015 | 1 | 19 | 23 | |
| GSE46452 | PDCD6IP | 10015 | 2 | 17 | 40 | |
| GSE47630 | PDCD6IP | 10015 | 1 | 25 | 14 | |
| GSE54993 | PDCD6IP | 10015 | 6 | 3 | 61 | |
| GSE54994 | PDCD6IP | 10015 | 1 | 32 | 20 | |
| GSE60625 | PDCD6IP | 10015 | 5 | 0 | 6 | |
| GSE74703 | PDCD6IP | 10015 | 1 | 16 | 19 | |
| GSE74704 | PDCD6IP | 10015 | 0 | 12 | 8 | |
| TCGA | PDCD6IP | 10015 | 1 | 70 | 25 |
Total number of gains: 18; Total number of losses: 230; Total Number of normals: 240.
Somatic mutations of PDCD6IP:
Generating mutation plots.
Highly correlated genes for PDCD6IP:
Showing top 20/1814 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDCD6IP | FRMD4B | 0.853128 | 11 | 0 | 11 |
| PDCD6IP | SFTA2 | 0.843911 | 4 | 0 | 4 |
| PDCD6IP | CLIC3 | 0.839253 | 9 | 0 | 9 |
| PDCD6IP | S100A14 | 0.836303 | 10 | 0 | 10 |
| PDCD6IP | ACAA1 | 0.834318 | 9 | 0 | 9 |
| PDCD6IP | CES2 | 0.834135 | 8 | 0 | 8 |
| PDCD6IP | MXD1 | 0.833652 | 10 | 0 | 10 |
| PDCD6IP | SLK | 0.829688 | 11 | 0 | 11 |
| PDCD6IP | RAB11A | 0.82968 | 11 | 0 | 11 |
| PDCD6IP | IL18 | 0.828722 | 10 | 0 | 10 |
| PDCD6IP | GYS2 | 0.827977 | 10 | 0 | 10 |
| PDCD6IP | SULT2B1 | 0.827964 | 8 | 0 | 8 |
| PDCD6IP | ECM1 | 0.827879 | 10 | 0 | 10 |
| PDCD6IP | C1orf116 | 0.827033 | 10 | 0 | 10 |
| PDCD6IP | CWH43 | 0.825298 | 10 | 0 | 10 |
| PDCD6IP | TMOD3 | 0.825073 | 11 | 0 | 10 |
| PDCD6IP | SERPINB1 | 0.823139 | 11 | 0 | 11 |
| PDCD6IP | C6orf132 | 0.821539 | 6 | 0 | 6 |
| PDCD6IP | SNX24 | 0.819775 | 9 | 0 | 9 |
| PDCD6IP | CRCT1 | 0.816276 | 10 | 0 | 10 |
For details and further investigation, click here
