| Full name: granulin precursor | Alias Symbol: PCDGF|PGRN|CLN11 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 2896 | HGNC ID: HGNC:4601 | Ensembl Gene: ENSG00000030582 | OMIM ID: 138945 |
| Drug and gene relationship at DGIdb | |||
Expression of GRN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRN | 2896 | 200678_x_at | -0.4795 | 0.3994 | |
| GSE20347 | GRN | 2896 | 200678_x_at | -1.5199 | 0.0000 | |
| GSE23400 | GRN | 2896 | 200678_x_at | -0.8135 | 0.0000 | |
| GSE26886 | GRN | 2896 | 200678_x_at | -1.4310 | 0.0000 | |
| GSE29001 | GRN | 2896 | 200678_x_at | -1.5372 | 0.0001 | |
| GSE38129 | GRN | 2896 | 200678_x_at | -0.8479 | 0.0004 | |
| GSE45670 | GRN | 2896 | 200678_x_at | -0.3764 | 0.0931 | |
| GSE53622 | GRN | 2896 | 44016 | 0.0925 | 0.1057 | |
| GSE53624 | GRN | 2896 | 53307 | -0.0456 | 0.3418 | |
| GSE63941 | GRN | 2896 | 200678_x_at | -0.4075 | 0.3768 | |
| GSE77861 | GRN | 2896 | 200678_x_at | -0.8958 | 0.0076 | |
| GSE97050 | GRN | 2896 | A_33_P3286278 | -0.0180 | 0.9705 | |
| SRP007169 | GRN | 2896 | RNAseq | -2.2692 | 0.0000 | |
| SRP008496 | GRN | 2896 | RNAseq | -2.2296 | 0.0000 | |
| SRP064894 | GRN | 2896 | RNAseq | 0.0210 | 0.9193 | |
| SRP133303 | GRN | 2896 | RNAseq | -0.8028 | 0.0020 | |
| SRP159526 | GRN | 2896 | RNAseq | -1.1892 | 0.0006 | |
| SRP193095 | GRN | 2896 | RNAseq | -0.9098 | 0.0000 | |
| SRP219564 | GRN | 2896 | RNAseq | -0.3881 | 0.4279 | |
| TCGA | GRN | 2896 | RNAseq | 0.1426 | 0.0041 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by GRN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRN | 2896 | 5 | 2 | 23 | |
| GSE20123 | GRN | 2896 | 5 | 2 | 23 | |
| GSE43470 | GRN | 2896 | 1 | 2 | 40 | |
| GSE46452 | GRN | 2896 | 32 | 0 | 27 | |
| GSE47630 | GRN | 2896 | 9 | 0 | 31 | |
| GSE54993 | GRN | 2896 | 3 | 4 | 63 | |
| GSE54994 | GRN | 2896 | 8 | 5 | 40 | |
| GSE60625 | GRN | 2896 | 4 | 0 | 7 | |
| GSE74703 | GRN | 2896 | 1 | 1 | 34 | |
| GSE74704 | GRN | 2896 | 3 | 1 | 16 | |
| TCGA | GRN | 2896 | 24 | 7 | 65 |
Total number of gains: 95; Total number of losses: 24; Total Number of normals: 369.
Somatic mutations of GRN:
Generating mutation plots.
Highly correlated genes for GRN:
Showing top 20/1483 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRN | TMEM79 | 0.830303 | 4 | 0 | 4 |
| GRN | DHRS1 | 0.812434 | 8 | 0 | 8 |
| GRN | TSPO | 0.79692 | 9 | 0 | 9 |
| GRN | EVPL | 0.786536 | 8 | 0 | 8 |
| GRN | LMAN2 | 0.782185 | 9 | 0 | 9 |
| GRN | PDCD6IP | 0.779482 | 9 | 0 | 9 |
| GRN | CYP2J2 | 0.772161 | 8 | 0 | 8 |
| GRN | ATP13A4 | 0.770363 | 3 | 0 | 3 |
| GRN | BNIPL | 0.769407 | 4 | 0 | 4 |
| GRN | LRP10 | 0.76746 | 9 | 0 | 9 |
| GRN | ALS2CL | 0.765949 | 8 | 0 | 8 |
| GRN | GYS2 | 0.762736 | 8 | 0 | 8 |
| GRN | EPS8L1 | 0.762686 | 8 | 0 | 8 |
| GRN | NAGK | 0.761458 | 10 | 0 | 9 |
| GRN | LYPD3 | 0.761272 | 8 | 0 | 8 |
| GRN | SORT1 | 0.760946 | 8 | 0 | 8 |
| GRN | CXCR2 | 0.760497 | 9 | 0 | 8 |
| GRN | GDPD3 | 0.760461 | 8 | 0 | 8 |
| GRN | NBEAL2 | 0.760366 | 8 | 0 | 7 |
| GRN | VAMP8 | 0.760135 | 8 | 0 | 8 |
For details and further investigation, click here
