| Full name: 2-hydroxyacyl-CoA lyase 1 | Alias Symbol: 2-HPCL|PHYH2 | ||
| Type: protein-coding gene | Cytoband: 3p25.1 | ||
| Entrez ID: 26061 | HGNC ID: HGNC:17856 | Ensembl Gene: ENSG00000131373 | OMIM ID: 604300 |
| Drug and gene relationship at DGIdb | |||
Expression of HACL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HACL1 | 26061 | 223211_at | -0.0303 | 0.9599 | |
| GSE26886 | HACL1 | 26061 | 223211_at | -0.2460 | 0.3254 | |
| GSE45670 | HACL1 | 26061 | 223211_at | -0.2201 | 0.1217 | |
| GSE53622 | HACL1 | 26061 | 58232 | -0.2969 | 0.0000 | |
| GSE53624 | HACL1 | 26061 | 58232 | -0.2521 | 0.0011 | |
| GSE63941 | HACL1 | 26061 | 223211_at | 0.4412 | 0.4043 | |
| GSE77861 | HACL1 | 26061 | 223211_at | -0.1982 | 0.3769 | |
| GSE97050 | HACL1 | 26061 | A_23_P121182 | -0.2770 | 0.2330 | |
| SRP007169 | HACL1 | 26061 | RNAseq | -0.1349 | 0.7306 | |
| SRP008496 | HACL1 | 26061 | RNAseq | 0.0726 | 0.7917 | |
| SRP064894 | HACL1 | 26061 | RNAseq | -0.0509 | 0.6984 | |
| SRP133303 | HACL1 | 26061 | RNAseq | -0.3881 | 0.0034 | |
| SRP159526 | HACL1 | 26061 | RNAseq | -0.2960 | 0.2654 | |
| SRP193095 | HACL1 | 26061 | RNAseq | -0.6330 | 0.0002 | |
| SRP219564 | HACL1 | 26061 | RNAseq | -0.4579 | 0.2997 | |
| TCGA | HACL1 | 26061 | RNAseq | -0.2685 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HACL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HACL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HACL1 | 26061 | 2 | 19 | 9 | |
| GSE20123 | HACL1 | 26061 | 2 | 19 | 9 | |
| GSE43470 | HACL1 | 26061 | 0 | 21 | 22 | |
| GSE46452 | HACL1 | 26061 | 2 | 17 | 40 | |
| GSE47630 | HACL1 | 26061 | 2 | 23 | 15 | |
| GSE54993 | HACL1 | 26061 | 6 | 1 | 63 | |
| GSE54994 | HACL1 | 26061 | 1 | 32 | 20 | |
| GSE60625 | HACL1 | 26061 | 5 | 0 | 6 | |
| GSE74703 | HACL1 | 26061 | 0 | 17 | 19 | |
| GSE74704 | HACL1 | 26061 | 1 | 13 | 6 | |
| TCGA | HACL1 | 26061 | 2 | 68 | 26 |
Total number of gains: 23; Total number of losses: 230; Total Number of normals: 235.
Somatic mutations of HACL1:
Generating mutation plots.
Highly correlated genes for HACL1:
Showing top 20/235 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HACL1 | VAMP3 | 0.756887 | 3 | 0 | 3 |
| HACL1 | GPANK1 | 0.739318 | 3 | 0 | 3 |
| HACL1 | MRPS18A | 0.72716 | 3 | 0 | 3 |
| HACL1 | PMPCB | 0.724819 | 3 | 0 | 3 |
| HACL1 | PPM1A | 0.721668 | 3 | 0 | 3 |
| HACL1 | ACP6 | 0.715679 | 4 | 0 | 3 |
| HACL1 | DIS3L | 0.710082 | 3 | 0 | 3 |
| HACL1 | ANK2 | 0.701678 | 3 | 0 | 3 |
| HACL1 | CBLL1 | 0.698444 | 3 | 0 | 3 |
| HACL1 | ZNF570 | 0.698324 | 3 | 0 | 3 |
| HACL1 | ZNF776 | 0.697541 | 3 | 0 | 3 |
| HACL1 | ZNF480 | 0.695059 | 3 | 0 | 3 |
| HACL1 | OR7E24 | 0.692671 | 3 | 0 | 3 |
| HACL1 | USE1 | 0.691651 | 4 | 0 | 3 |
| HACL1 | FAM32A | 0.690616 | 3 | 0 | 3 |
| HACL1 | CEP70 | 0.687153 | 3 | 0 | 3 |
| HACL1 | SOS2 | 0.679008 | 3 | 0 | 3 |
| HACL1 | CAMK1 | 0.66937 | 3 | 0 | 3 |
| HACL1 | ZMYM2 | 0.661567 | 3 | 0 | 3 |
| HACL1 | DCP1A | 0.660199 | 3 | 0 | 3 |
For details and further investigation, click here
