| Full name: protein phosphatase, Mg2+/Mn2+ dependent 1A | Alias Symbol: MGC9201|PP2Calpha|PP2CA | ||
| Type: protein-coding gene | Cytoband: 14q23.1 | ||
| Entrez ID: 5494 | HGNC ID: HGNC:9275 | Ensembl Gene: ENSG00000100614 | OMIM ID: 606108 |
| Drug and gene relationship at DGIdb | |||
PPM1A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of PPM1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPM1A | 5494 | 203966_s_at | 0.0076 | 0.9908 | |
| GSE20347 | PPM1A | 5494 | 203966_s_at | -0.2893 | 0.0623 | |
| GSE23400 | PPM1A | 5494 | 203966_s_at | -0.1820 | 0.0009 | |
| GSE26886 | PPM1A | 5494 | 203966_s_at | -0.2886 | 0.2591 | |
| GSE29001 | PPM1A | 5494 | 203966_s_at | -0.3263 | 0.2704 | |
| GSE38129 | PPM1A | 5494 | 203966_s_at | -0.2933 | 0.0166 | |
| GSE45670 | PPM1A | 5494 | 203966_s_at | -0.3621 | 0.0017 | |
| GSE53622 | PPM1A | 5494 | 129337 | -0.1143 | 0.1004 | |
| GSE53624 | PPM1A | 5494 | 129337 | -0.2315 | 0.0001 | |
| GSE63941 | PPM1A | 5494 | 203966_s_at | -0.4656 | 0.1792 | |
| GSE77861 | PPM1A | 5494 | 203966_s_at | -0.3285 | 0.2532 | |
| GSE97050 | PPM1A | 5494 | A_24_P407323 | -0.3092 | 0.3185 | |
| SRP007169 | PPM1A | 5494 | RNAseq | -1.0899 | 0.0023 | |
| SRP008496 | PPM1A | 5494 | RNAseq | -0.8507 | 0.0002 | |
| SRP064894 | PPM1A | 5494 | RNAseq | -0.4811 | 0.0091 | |
| SRP133303 | PPM1A | 5494 | RNAseq | 0.0475 | 0.8073 | |
| SRP159526 | PPM1A | 5494 | RNAseq | -0.4692 | 0.0322 | |
| SRP193095 | PPM1A | 5494 | RNAseq | -0.2854 | 0.0084 | |
| SRP219564 | PPM1A | 5494 | RNAseq | -0.5089 | 0.1465 | |
| TCGA | PPM1A | 5494 | RNAseq | -0.1115 | 0.0156 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PPM1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPM1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPM1A | 5494 | 8 | 3 | 19 | |
| GSE20123 | PPM1A | 5494 | 7 | 3 | 20 | |
| GSE43470 | PPM1A | 5494 | 8 | 2 | 33 | |
| GSE46452 | PPM1A | 5494 | 16 | 3 | 40 | |
| GSE47630 | PPM1A | 5494 | 11 | 9 | 20 | |
| GSE54993 | PPM1A | 5494 | 3 | 9 | 58 | |
| GSE54994 | PPM1A | 5494 | 19 | 4 | 30 | |
| GSE60625 | PPM1A | 5494 | 0 | 2 | 9 | |
| GSE74703 | PPM1A | 5494 | 7 | 2 | 27 | |
| GSE74704 | PPM1A | 5494 | 3 | 2 | 15 | |
| TCGA | PPM1A | 5494 | 32 | 14 | 50 |
Total number of gains: 114; Total number of losses: 53; Total Number of normals: 321.
Somatic mutations of PPM1A:
Generating mutation plots.
Highly correlated genes for PPM1A:
Showing top 20/425 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPM1A | RNF144B | 0.853884 | 3 | 0 | 3 |
| PPM1A | RRAGC | 0.814885 | 3 | 0 | 3 |
| PPM1A | RPP30 | 0.812982 | 3 | 0 | 3 |
| PPM1A | ZNF518A | 0.804561 | 3 | 0 | 3 |
| PPM1A | LZIC | 0.796348 | 3 | 0 | 3 |
| PPM1A | C2orf76 | 0.769839 | 3 | 0 | 3 |
| PPM1A | OTUD7B | 0.767755 | 3 | 0 | 3 |
| PPM1A | KDM3A | 0.767186 | 3 | 0 | 3 |
| PPM1A | TOR1AIP2 | 0.76324 | 3 | 0 | 3 |
| PPM1A | PARG | 0.762321 | 3 | 0 | 3 |
| PPM1A | EFCAB7 | 0.742416 | 3 | 0 | 3 |
| PPM1A | ACBD5 | 0.74005 | 3 | 0 | 3 |
| PPM1A | PTPN12 | 0.732374 | 3 | 0 | 3 |
| PPM1A | SRSF6 | 0.732094 | 3 | 0 | 3 |
| PPM1A | ATAD1 | 0.727164 | 3 | 0 | 3 |
| PPM1A | HACL1 | 0.721668 | 3 | 0 | 3 |
| PPM1A | GTF2B | 0.719747 | 4 | 0 | 4 |
| PPM1A | ZNF578 | 0.719285 | 3 | 0 | 3 |
| PPM1A | SGMS1 | 0.712721 | 4 | 0 | 3 |
| PPM1A | HDHD2 | 0.710548 | 3 | 0 | 3 |
For details and further investigation, click here
