SOS2

 

Full name: SOS Ras/Rho guanine nucleotide exchange factor 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 14q21.3
Entrez ID: 6655 HGNC ID: HGNC:11188 Ensembl Gene: ENSG00000100485 OMIM ID: 601247
Drug and gene relationship at DGIdb

 

SOS2 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04068FoxO signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04540Gap junction
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa05034Alcoholism
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05211Renal cell carcinoma
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of SOS2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SOS2 6655 212870_at -0.3166 0.6088
GSE20347 SOS2 6655 212870_at -0.6502 0.0001
GSE23400 SOS2 6655 212870_at -0.1553 0.0464
GSE26886 SOS2 6655 212870_at -0.4243 0.0652
GSE29001 SOS2 6655 212870_at -0.4977 0.0808
GSE38129 SOS2 6655 212870_at -0.7119 0.0000
GSE45670 SOS2 6655 212870_at -0.4533 0.0008
GSE53622 SOS2 6655 1227 -0.3214 0.0000
GSE53624 SOS2 6655 1227 -0.4886 0.0000
GSE63941 SOS2 6655 212870_at -0.5048 0.3663
GSE77861 SOS2 6655 212870_at -0.6672 0.0703
GSE97050 SOS2 6655 A_23_P117546 -0.0542 0.8836
SRP007169 SOS2 6655 RNAseq -1.4617 0.0000
SRP008496 SOS2 6655 RNAseq -1.1980 0.0000
SRP064894 SOS2 6655 RNAseq -0.4200 0.0409
SRP133303 SOS2 6655 RNAseq -0.0967 0.6165
SRP159526 SOS2 6655 RNAseq -0.7074 0.0000
SRP193095 SOS2 6655 RNAseq -0.4022 0.0001
SRP219564 SOS2 6655 RNAseq -0.3869 0.1411
TCGA SOS2 6655 RNAseq -0.1409 0.0049

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by SOS2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SOS2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SOS2 6655 9 2 19
GSE20123 SOS2 6655 9 3 18
GSE43470 SOS2 6655 8 1 34
GSE46452 SOS2 6655 16 3 40
GSE47630 SOS2 6655 11 10 19
GSE54993 SOS2 6655 3 9 58
GSE54994 SOS2 6655 19 4 30
GSE60625 SOS2 6655 0 2 9
GSE74703 SOS2 6655 7 1 28
GSE74704 SOS2 6655 4 2 14
TCGA SOS2 6655 34 13 49

Total number of gains: 120; Total number of losses: 50; Total Number of normals: 318.  

 

Somatic mutations of SOS2:

 

Generating mutation plots.

 

Highly correlated genes for SOS2:

 

Showing top 20/914 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SOS2RRAGC0.813431303
SOS2GPBP10.790308303
SOS2KDM3A0.769049303
SOS2SLC25A430.759284303
SOS2DYNLRB20.746111303
SOS2EIF2B10.736484303
SOS2DCP20.732735303
SOS2GLYR10.727887303
SOS2TPD52L20.720896303
SOS2ICA1L0.720653303
SOS2ZFP620.720632303
SOS2SS180.720241303
SOS2ARIH20.717196403
SOS2TADA10.713973303
SOS2LARP1B0.707951303
SOS2PTPN210.707898606
SOS2KCTD100.707412303
SOS2SNX180.696375303
SOS2RABL30.69567505
SOS2NDUFA120.695583303

For details and further investigation, click here