| Full name: huntingtin associated protein 1 | Alias Symbol: HLP|hHLP1|HIP5 | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 9001 | HGNC ID: HGNC:4812 | Ensembl Gene: ENSG00000173805 | OMIM ID: 600947 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HAP1 | 9001 | 211604_x_at | -0.0509 | 0.8516 | |
| GSE20347 | HAP1 | 9001 | 211604_x_at | 0.0352 | 0.7280 | |
| GSE23400 | HAP1 | 9001 | 211222_s_at | 0.0261 | 0.7201 | |
| GSE26886 | HAP1 | 9001 | 211604_x_at | 0.1740 | 0.1230 | |
| GSE29001 | HAP1 | 9001 | 211222_s_at | -0.0265 | 0.8925 | |
| GSE38129 | HAP1 | 9001 | 211604_x_at | -0.0461 | 0.6484 | |
| GSE45670 | HAP1 | 9001 | 211604_x_at | -0.0736 | 0.4178 | |
| GSE53622 | HAP1 | 9001 | 60718 | 0.4241 | 0.0000 | |
| GSE53624 | HAP1 | 9001 | 60718 | 0.1413 | 0.1438 | |
| GSE63941 | HAP1 | 9001 | 211604_x_at | 0.3555 | 0.0333 | |
| GSE77861 | HAP1 | 9001 | 211604_x_at | 0.0837 | 0.6553 | |
| GSE97050 | HAP1 | 9001 | A_23_P22129 | 0.5450 | 0.1476 | |
| SRP007169 | HAP1 | 9001 | RNAseq | 5.9882 | 0.0000 | |
| SRP133303 | HAP1 | 9001 | RNAseq | 2.3861 | 0.0000 | |
| SRP159526 | HAP1 | 9001 | RNAseq | 4.1718 | 0.0000 | |
| SRP219564 | HAP1 | 9001 | RNAseq | 3.2329 | 0.0002 | |
| TCGA | HAP1 | 9001 | RNAseq | 3.0271 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by HAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HAP1 | 9001 | 6 | 2 | 22 | |
| GSE20123 | HAP1 | 9001 | 6 | 2 | 22 | |
| GSE43470 | HAP1 | 9001 | 1 | 2 | 40 | |
| GSE46452 | HAP1 | 9001 | 34 | 0 | 25 | |
| GSE47630 | HAP1 | 9001 | 8 | 1 | 31 | |
| GSE54993 | HAP1 | 9001 | 3 | 4 | 63 | |
| GSE54994 | HAP1 | 9001 | 8 | 5 | 40 | |
| GSE60625 | HAP1 | 9001 | 4 | 0 | 7 | |
| GSE74703 | HAP1 | 9001 | 1 | 1 | 34 | |
| GSE74704 | HAP1 | 9001 | 4 | 1 | 15 | |
| TCGA | HAP1 | 9001 | 23 | 7 | 66 |
Total number of gains: 98; Total number of losses: 25; Total Number of normals: 365.
Somatic mutations of HAP1:
Generating mutation plots.
Highly correlated genes for HAP1:
Showing top 20/764 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HAP1 | GRIK4 | 0.781846 | 3 | 0 | 3 |
| HAP1 | POLM | 0.756631 | 3 | 0 | 3 |
| HAP1 | CALML6 | 0.748972 | 3 | 0 | 3 |
| HAP1 | UFSP1 | 0.740028 | 3 | 0 | 3 |
| HAP1 | GPR150 | 0.734296 | 3 | 0 | 3 |
| HAP1 | CFC1 | 0.733463 | 3 | 0 | 3 |
| HAP1 | TAS2R40 | 0.727358 | 3 | 0 | 3 |
| HAP1 | C20orf85 | 0.712686 | 3 | 0 | 3 |
| HAP1 | TCTE1 | 0.708429 | 5 | 0 | 4 |
| HAP1 | MS4A18 | 0.707037 | 3 | 0 | 3 |
| HAP1 | OR5A1 | 0.702081 | 3 | 0 | 3 |
| HAP1 | KRT77 | 0.698494 | 4 | 0 | 4 |
| HAP1 | KIFC2 | 0.695392 | 4 | 0 | 4 |
| HAP1 | ASB4 | 0.695305 | 3 | 0 | 3 |
| HAP1 | LCN9 | 0.694804 | 3 | 0 | 3 |
| HAP1 | PSMB11 | 0.691388 | 3 | 0 | 3 |
| HAP1 | LINC00474 | 0.689034 | 5 | 0 | 5 |
| HAP1 | TCL6 | 0.68865 | 4 | 0 | 4 |
| HAP1 | CCDC106 | 0.681047 | 4 | 0 | 4 |
| HAP1 | CA6 | 0.679084 | 4 | 0 | 4 |
For details and further investigation, click here
