| Full name: histone deacetylase 4 | Alias Symbol: KIAA0288|HDAC-A|HDACA|HD4|HA6116|HDAC-4 | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 9759 | HGNC ID: HGNC:14063 | Ensembl Gene: ENSG00000068024 | OMIM ID: 605314 |
| Drug and gene relationship at DGIdb | |||
Expression of HDAC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HDAC4 | 9759 | 204225_at | 0.1089 | 0.9548 | |
| GSE20347 | HDAC4 | 9759 | 204225_at | -0.2093 | 0.3285 | |
| GSE23400 | HDAC4 | 9759 | 204225_at | -0.2913 | 0.0162 | |
| GSE26886 | HDAC4 | 9759 | 204225_at | -0.5311 | 0.0541 | |
| GSE29001 | HDAC4 | 9759 | 204225_at | -0.2434 | 0.5833 | |
| GSE38129 | HDAC4 | 9759 | 204225_at | -0.3261 | 0.0792 | |
| GSE45670 | HDAC4 | 9759 | 204225_at | 0.0203 | 0.9365 | |
| GSE63941 | HDAC4 | 9759 | 204225_at | -1.8048 | 0.0084 | |
| GSE77861 | HDAC4 | 9759 | 204225_at | 0.6573 | 0.0216 | |
| GSE97050 | HDAC4 | 9759 | A_23_P210048 | -0.2050 | 0.4861 | |
| SRP007169 | HDAC4 | 9759 | RNAseq | 0.8248 | 0.1365 | |
| SRP008496 | HDAC4 | 9759 | RNAseq | 0.8383 | 0.0567 | |
| SRP064894 | HDAC4 | 9759 | RNAseq | -0.5578 | 0.0112 | |
| SRP133303 | HDAC4 | 9759 | RNAseq | -0.5033 | 0.0177 | |
| SRP159526 | HDAC4 | 9759 | RNAseq | -0.1037 | 0.6142 | |
| SRP193095 | HDAC4 | 9759 | RNAseq | 0.0200 | 0.8860 | |
| SRP219564 | HDAC4 | 9759 | RNAseq | -0.5609 | 0.2791 | |
| TCGA | HDAC4 | 9759 | RNAseq | -0.1506 | 0.0348 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HDAC4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of HDAC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HDAC4 | 9759 | 1 | 12 | 17 | |
| GSE20123 | HDAC4 | 9759 | 1 | 12 | 17 | |
| GSE43470 | HDAC4 | 9759 | 1 | 10 | 32 | |
| GSE46452 | HDAC4 | 9759 | 0 | 5 | 54 | |
| GSE47630 | HDAC4 | 9759 | 4 | 5 | 31 | |
| GSE54993 | HDAC4 | 9759 | 3 | 3 | 64 | |
| GSE54994 | HDAC4 | 9759 | 8 | 9 | 36 | |
| GSE60625 | HDAC4 | 9759 | 0 | 3 | 8 | |
| GSE74703 | HDAC4 | 9759 | 1 | 8 | 27 | |
| GSE74704 | HDAC4 | 9759 | 1 | 5 | 14 | |
| TCGA | HDAC4 | 9759 | 12 | 28 | 56 |
Total number of gains: 32; Total number of losses: 100; Total Number of normals: 356.
Somatic mutations of HDAC4:
Generating mutation plots.
Highly correlated genes for HDAC4:
Showing top 20/37 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HDAC4 | ETFB | 0.711604 | 3 | 0 | 3 |
| HDAC4 | CASC15 | 0.694549 | 3 | 0 | 3 |
| HDAC4 | PAG1 | 0.686347 | 3 | 0 | 3 |
| HDAC4 | TCEAL7 | 0.681339 | 3 | 0 | 3 |
| HDAC4 | EML6 | 0.665682 | 3 | 0 | 3 |
| HDAC4 | ING5 | 0.642901 | 3 | 0 | 3 |
| HDAC4 | ENOX2 | 0.625373 | 3 | 0 | 3 |
| HDAC4 | SVIL | 0.59928 | 5 | 0 | 3 |
| HDAC4 | NPR2 | 0.582632 | 4 | 0 | 3 |
| HDAC4 | FBXO38 | 0.579422 | 4 | 0 | 3 |
| HDAC4 | TSPAN18 | 0.579258 | 3 | 0 | 3 |
| HDAC4 | SCN9A | 0.578561 | 7 | 0 | 4 |
| HDAC4 | IRGQ | 0.574791 | 5 | 0 | 3 |
| HDAC4 | CYP39A1 | 0.572717 | 5 | 0 | 3 |
| HDAC4 | FBN2 | 0.5723 | 5 | 0 | 3 |
| HDAC4 | FLRT3 | 0.571464 | 3 | 0 | 3 |
| HDAC4 | BCL2L13 | 0.56943 | 6 | 0 | 3 |
| HDAC4 | RNF216 | 0.565572 | 4 | 0 | 3 |
| HDAC4 | FASTK | 0.564845 | 4 | 0 | 3 |
| HDAC4 | ASB1 | 0.562246 | 7 | 0 | 4 |
For details and further investigation, click here
