| Full name: cytochrome P450 family 39 subfamily A member 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p12.3 | ||
| Entrez ID: 51302 | HGNC ID: HGNC:17449 | Ensembl Gene: ENSG00000146233 | OMIM ID: 605994 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP39A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP39A1 | 51302 | 1553977_a_at | 0.0823 | 0.9217 | |
| GSE20347 | CYP39A1 | 51302 | 220432_s_at | -0.0939 | 0.8487 | |
| GSE23400 | CYP39A1 | 51302 | 220432_s_at | -0.0190 | 0.7856 | |
| GSE26886 | CYP39A1 | 51302 | 1553977_a_at | -0.5479 | 0.0399 | |
| GSE29001 | CYP39A1 | 51302 | 220432_s_at | 0.1347 | 0.8905 | |
| GSE38129 | CYP39A1 | 51302 | 220432_s_at | -0.5690 | 0.1387 | |
| GSE45670 | CYP39A1 | 51302 | 1553977_a_at | -0.0056 | 0.9889 | |
| GSE53622 | CYP39A1 | 51302 | 150693 | -0.4976 | 0.0147 | |
| GSE53624 | CYP39A1 | 51302 | 150693 | -0.3110 | 0.0471 | |
| GSE63941 | CYP39A1 | 51302 | 1553977_a_at | -2.6945 | 0.0004 | |
| GSE77861 | CYP39A1 | 51302 | 1553977_a_at | -0.0206 | 0.9689 | |
| GSE97050 | CYP39A1 | 51302 | A_23_P133712 | -0.2866 | 0.4219 | |
| SRP007169 | CYP39A1 | 51302 | RNAseq | -2.3209 | 0.0004 | |
| SRP064894 | CYP39A1 | 51302 | RNAseq | -0.3182 | 0.2761 | |
| SRP133303 | CYP39A1 | 51302 | RNAseq | -0.3650 | 0.3802 | |
| SRP159526 | CYP39A1 | 51302 | RNAseq | -0.6346 | 0.0247 | |
| SRP193095 | CYP39A1 | 51302 | RNAseq | 0.1410 | 0.5742 | |
| SRP219564 | CYP39A1 | 51302 | RNAseq | 0.3853 | 0.5098 | |
| TCGA | CYP39A1 | 51302 | RNAseq | -0.3437 | 0.2028 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CYP39A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP39A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP39A1 | 51302 | 6 | 2 | 22 | |
| GSE20123 | CYP39A1 | 51302 | 6 | 2 | 22 | |
| GSE43470 | CYP39A1 | 51302 | 5 | 0 | 38 | |
| GSE46452 | CYP39A1 | 51302 | 2 | 10 | 47 | |
| GSE47630 | CYP39A1 | 51302 | 7 | 5 | 28 | |
| GSE54993 | CYP39A1 | 51302 | 3 | 1 | 66 | |
| GSE54994 | CYP39A1 | 51302 | 8 | 3 | 42 | |
| GSE60625 | CYP39A1 | 51302 | 0 | 3 | 8 | |
| GSE74703 | CYP39A1 | 51302 | 5 | 0 | 31 | |
| GSE74704 | CYP39A1 | 51302 | 2 | 1 | 17 | |
| TCGA | CYP39A1 | 51302 | 19 | 14 | 63 |
Total number of gains: 63; Total number of losses: 41; Total Number of normals: 384.
Somatic mutations of CYP39A1:
Generating mutation plots.
Highly correlated genes for CYP39A1:
Showing top 20/39 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP39A1 | RNF212B | 0.744917 | 3 | 0 | 3 |
| CYP39A1 | FANK1 | 0.743495 | 3 | 0 | 3 |
| CYP39A1 | WDR91 | 0.697207 | 4 | 0 | 3 |
| CYP39A1 | ENTPD1 | 0.692986 | 3 | 0 | 3 |
| CYP39A1 | MFSD1 | 0.664789 | 3 | 0 | 3 |
| CYP39A1 | GSTM5 | 0.655115 | 4 | 0 | 4 |
| CYP39A1 | TMEM217 | 0.646703 | 3 | 0 | 3 |
| CYP39A1 | PROC | 0.644074 | 5 | 0 | 5 |
| CYP39A1 | GM2A | 0.615094 | 4 | 0 | 3 |
| CYP39A1 | VAV2 | 0.611019 | 3 | 0 | 3 |
| CYP39A1 | TCEAL7 | 0.610478 | 5 | 0 | 3 |
| CYP39A1 | COL16A1 | 0.609581 | 6 | 0 | 4 |
| CYP39A1 | HSF2BP | 0.608884 | 4 | 0 | 3 |
| CYP39A1 | CDH2 | 0.585255 | 4 | 0 | 3 |
| CYP39A1 | LDB2 | 0.582083 | 5 | 0 | 3 |
| CYP39A1 | HDAC4 | 0.572717 | 5 | 0 | 3 |
| CYP39A1 | FLRT3 | 0.570023 | 7 | 0 | 4 |
| CYP39A1 | COQ6 | 0.567114 | 6 | 0 | 4 |
| CYP39A1 | TDRD6 | 0.562673 | 4 | 0 | 3 |
| CYP39A1 | NCKAP5 | 0.556988 | 7 | 0 | 4 |
For details and further investigation, click here
