| Full name: denticleless E3 ubiquitin protein ligase homolog | Alias Symbol: RAMP|L2DTL|DCAF2|CDT2 | ||
| Type: protein-coding gene | Cytoband: 1q32.3 | ||
| Entrez ID: 51514 | HGNC ID: HGNC:30288 | Ensembl Gene: ENSG00000143476 | OMIM ID: 610617 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DTL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DTL | 51514 | 218585_s_at | 1.6273 | 0.0289 | |
| GSE20347 | DTL | 51514 | 218585_s_at | 1.6414 | 0.0000 | |
| GSE23400 | DTL | 51514 | 218585_s_at | 1.6790 | 0.0000 | |
| GSE26886 | DTL | 51514 | 218585_s_at | 1.1652 | 0.0000 | |
| GSE29001 | DTL | 51514 | 218585_s_at | 1.7078 | 0.0012 | |
| GSE38129 | DTL | 51514 | 218585_s_at | 2.0947 | 0.0000 | |
| GSE45670 | DTL | 51514 | 218585_s_at | 1.6928 | 0.0000 | |
| GSE53622 | DTL | 51514 | 106409 | 1.9328 | 0.0000 | |
| GSE53624 | DTL | 51514 | 106409 | 2.1173 | 0.0000 | |
| GSE63941 | DTL | 51514 | 218585_s_at | 3.0224 | 0.0002 | |
| GSE77861 | DTL | 51514 | 218585_s_at | 1.6029 | 0.0005 | |
| GSE97050 | DTL | 51514 | A_23_P10385 | 1.3504 | 0.0847 | |
| SRP007169 | DTL | 51514 | RNAseq | 1.8542 | 0.0000 | |
| SRP008496 | DTL | 51514 | RNAseq | 1.9714 | 0.0000 | |
| SRP064894 | DTL | 51514 | RNAseq | 1.4903 | 0.0000 | |
| SRP133303 | DTL | 51514 | RNAseq | 1.9915 | 0.0000 | |
| SRP159526 | DTL | 51514 | RNAseq | 2.4151 | 0.0000 | |
| SRP193095 | DTL | 51514 | RNAseq | 1.3708 | 0.0000 | |
| SRP219564 | DTL | 51514 | RNAseq | 2.9326 | 0.0000 | |
| TCGA | DTL | 51514 | RNAseq | 1.2326 | 0.0000 |
Upregulated datasets: 19; Downregulated datasets: 0.
Survival by DTL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DTL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DTL | 51514 | 11 | 0 | 19 | |
| GSE20123 | DTL | 51514 | 11 | 0 | 19 | |
| GSE43470 | DTL | 51514 | 7 | 0 | 36 | |
| GSE46452 | DTL | 51514 | 3 | 1 | 55 | |
| GSE47630 | DTL | 51514 | 15 | 0 | 25 | |
| GSE54993 | DTL | 51514 | 0 | 6 | 64 | |
| GSE54994 | DTL | 51514 | 13 | 0 | 40 | |
| GSE60625 | DTL | 51514 | 0 | 0 | 11 | |
| GSE74703 | DTL | 51514 | 7 | 0 | 29 | |
| GSE74704 | DTL | 51514 | 5 | 0 | 15 | |
| TCGA | DTL | 51514 | 44 | 3 | 49 |
Total number of gains: 116; Total number of losses: 10; Total Number of normals: 362.
Somatic mutations of DTL:
Generating mutation plots.
Highly correlated genes for DTL:
Showing top 20/2162 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DTL | CENPF | 0.869885 | 13 | 0 | 12 |
| DTL | NEK2 | 0.867505 | 13 | 0 | 13 |
| DTL | GINS1 | 0.86371 | 12 | 0 | 12 |
| DTL | ASPM | 0.854349 | 13 | 0 | 13 |
| DTL | GMNN | 0.848395 | 13 | 0 | 13 |
| DTL | KIF14 | 0.84754 | 13 | 0 | 12 |
| DTL | UBE2T | 0.842097 | 9 | 0 | 9 |
| DTL | MTFR2 | 0.833559 | 7 | 0 | 7 |
| DTL | NUSAP1 | 0.833392 | 13 | 0 | 13 |
| DTL | MCM2 | 0.832998 | 12 | 0 | 12 |
| DTL | CCNB2 | 0.832899 | 12 | 0 | 12 |
| DTL | KIF20A | 0.832438 | 12 | 0 | 12 |
| DTL | MMS22L | 0.831847 | 3 | 0 | 3 |
| DTL | NUF2 | 0.831127 | 9 | 0 | 9 |
| DTL | TIMELESS | 0.830688 | 13 | 0 | 13 |
| DTL | GINS2 | 0.829019 | 12 | 0 | 12 |
| DTL | MCM6 | 0.828867 | 13 | 0 | 13 |
| DTL | RFC4 | 0.827986 | 13 | 0 | 13 |
| DTL | KIF2C | 0.826549 | 12 | 0 | 12 |
| DTL | BUB1B | 0.824658 | 10 | 0 | 9 |
For details and further investigation, click here
