DNAJC2

 

Full name: DnaJ heat shock protein family (Hsp40) member C2 Alias Symbol: MPP11|MPHOSPH11|ZUO1|zuotin
Type: protein-coding gene Cytoband: 7q22.1
Entrez ID: 27000 HGNC ID: HGNC:13192 Ensembl Gene: ENSG00000105821 OMIM ID: 605502
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of DNAJC2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DNAJC2 27000 213097_s_at 1.0209 0.0234
GSE20347 DNAJC2 27000 213097_s_at 0.9823 0.0000
GSE23400 DNAJC2 27000 213097_s_at 0.7745 0.0000
GSE26886 DNAJC2 27000 213097_s_at 2.0062 0.0000
GSE29001 DNAJC2 27000 213097_s_at 0.8817 0.0003
GSE38129 DNAJC2 27000 213097_s_at 1.1028 0.0000
GSE45670 DNAJC2 27000 213097_s_at 0.8708 0.0008
GSE53622 DNAJC2 27000 137831 0.6750 0.0000
GSE53624 DNAJC2 27000 137831 1.0308 0.0000
GSE63941 DNAJC2 27000 213097_s_at 0.1945 0.7504
GSE77861 DNAJC2 27000 213097_s_at 1.0749 0.0002
GSE97050 DNAJC2 27000 A_23_P254573 0.3933 0.2351
SRP007169 DNAJC2 27000 RNAseq 1.9106 0.0006
SRP008496 DNAJC2 27000 RNAseq 1.8447 0.0000
SRP064894 DNAJC2 27000 RNAseq 0.7269 0.0000
SRP133303 DNAJC2 27000 RNAseq 1.0148 0.0000
SRP159526 DNAJC2 27000 RNAseq 0.7446 0.0061
SRP193095 DNAJC2 27000 RNAseq 0.7562 0.0000
SRP219564 DNAJC2 27000 RNAseq 0.7715 0.0875
TCGA DNAJC2 27000 RNAseq 0.2611 0.0000

Upregulated datasets: 8; Downregulated datasets: 0.  

 

Survival by DNAJC2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DNAJC2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DNAJC2 27000 13 0 17
GSE20123 DNAJC2 27000 13 0 17
GSE43470 DNAJC2 27000 6 1 36
GSE46452 DNAJC2 27000 10 1 48
GSE47630 DNAJC2 27000 7 3 30
GSE54993 DNAJC2 27000 1 10 59
GSE54994 DNAJC2 27000 15 3 35
GSE60625 DNAJC2 27000 0 0 11
GSE74703 DNAJC2 27000 6 1 29
GSE74704 DNAJC2 27000 9 0 11
TCGA DNAJC2 27000 54 6 36

Total number of gains: 134; Total number of losses: 25; Total Number of normals: 329.  

 

Somatic mutations of DNAJC2:

 

Generating mutation plots.

 

Highly correlated genes for DNAJC2:

 

Showing top 20/2319 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DNAJC2PTCD10.83022303
DNAJC2U2SURP0.809274909
DNAJC2NCAPG0.795919909
DNAJC2SPIRE10.794042303
DNAJC2TCF30.79352211011
DNAJC2MCM60.79346611011
DNAJC2CCT6A0.793235808
DNAJC2GMPS0.78780411011
DNAJC2SLC25A290.782599303
DNAJC2SNRPG0.78138311011
DNAJC2PUS70.77771912012
DNAJC2GMNN0.77750311011
DNAJC2DNMT10.77749511011
DNAJC2ECT20.77746310010
DNAJC2UBE2C0.77696411011
DNAJC2ZBTB8OS0.774818303
DNAJC2TMEM970.77345211011
DNAJC2MORC20.77185511011
DNAJC2FLVCR10.77179707
DNAJC2CMTM40.771703404

For details and further investigation, click here