| Full name: RNA polymerase I subunit A | Alias Symbol: DKFZP586M0122|FLJ21915|RPO1-4|RPA1 | ||
| Type: protein-coding gene | Cytoband: 2p11.2 | ||
| Entrez ID: 25885 | HGNC ID: HGNC:17264 | Ensembl Gene: ENSG00000068654 | OMIM ID: 616404 |
| Drug and gene relationship at DGIdb | |||
Expression of POLR1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLR1A | 25885 | 222704_at | 0.7567 | 0.0148 | |
| GSE26886 | POLR1A | 25885 | 222704_at | 0.1200 | 0.3328 | |
| GSE45670 | POLR1A | 25885 | 222704_at | 0.6658 | 0.0000 | |
| GSE53622 | POLR1A | 25885 | 34855 | -0.0826 | 0.5411 | |
| GSE53624 | POLR1A | 25885 | 28089 | 0.1811 | 0.0271 | |
| GSE63941 | POLR1A | 25885 | 222704_at | 0.1034 | 0.7953 | |
| GSE77861 | POLR1A | 25885 | 222704_at | 0.3264 | 0.1714 | |
| GSE97050 | POLR1A | 25885 | A_33_P3610123 | 0.3982 | 0.2354 | |
| SRP007169 | POLR1A | 25885 | RNAseq | 1.7514 | 0.0001 | |
| SRP008496 | POLR1A | 25885 | RNAseq | 1.8164 | 0.0000 | |
| SRP064894 | POLR1A | 25885 | RNAseq | 0.4991 | 0.0018 | |
| SRP133303 | POLR1A | 25885 | RNAseq | 0.5492 | 0.0000 | |
| SRP159526 | POLR1A | 25885 | RNAseq | 0.8648 | 0.0023 | |
| SRP193095 | POLR1A | 25885 | RNAseq | 0.5150 | 0.0000 | |
| SRP219564 | POLR1A | 25885 | RNAseq | 0.4055 | 0.2817 | |
| TCGA | POLR1A | 25885 | RNAseq | 0.1108 | 0.0546 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by POLR1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLR1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLR1A | 25885 | 9 | 2 | 19 | |
| GSE20123 | POLR1A | 25885 | 9 | 2 | 19 | |
| GSE43470 | POLR1A | 25885 | 4 | 2 | 37 | |
| GSE46452 | POLR1A | 25885 | 2 | 3 | 54 | |
| GSE47630 | POLR1A | 25885 | 7 | 0 | 33 | |
| GSE54993 | POLR1A | 25885 | 0 | 6 | 64 | |
| GSE54994 | POLR1A | 25885 | 10 | 0 | 43 | |
| GSE60625 | POLR1A | 25885 | 0 | 3 | 8 | |
| GSE74703 | POLR1A | 25885 | 4 | 1 | 31 | |
| GSE74704 | POLR1A | 25885 | 7 | 0 | 13 | |
| TCGA | POLR1A | 25885 | 35 | 4 | 57 |
Total number of gains: 87; Total number of losses: 23; Total Number of normals: 378.
Somatic mutations of POLR1A:
Generating mutation plots.
Highly correlated genes for POLR1A:
Showing top 20/457 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLR1A | KIF18A | 0.764905 | 3 | 0 | 3 |
| POLR1A | MIEF1 | 0.764462 | 3 | 0 | 3 |
| POLR1A | HEATR1 | 0.761758 | 3 | 0 | 3 |
| POLR1A | CCDC86 | 0.756702 | 3 | 0 | 3 |
| POLR1A | KIF2C | 0.748975 | 3 | 0 | 3 |
| POLR1A | KIF18B | 0.748227 | 3 | 0 | 3 |
| POLR1A | DEPDC1B | 0.747659 | 4 | 0 | 4 |
| POLR1A | MRPS17 | 0.744381 | 4 | 0 | 4 |
| POLR1A | GMNN | 0.739337 | 3 | 0 | 3 |
| POLR1A | HMGB3 | 0.736607 | 3 | 0 | 3 |
| POLR1A | CDC25C | 0.736297 | 3 | 0 | 3 |
| POLR1A | PC | 0.733093 | 3 | 0 | 3 |
| POLR1A | MTFR2 | 0.730492 | 3 | 0 | 3 |
| POLR1A | CDT1 | 0.726997 | 3 | 0 | 3 |
| POLR1A | CENPA | 0.726915 | 3 | 0 | 3 |
| POLR1A | TMEM185B | 0.725392 | 3 | 0 | 3 |
| POLR1A | PHF5A | 0.72302 | 3 | 0 | 3 |
| POLR1A | SLC39A4 | 0.722288 | 3 | 0 | 3 |
| POLR1A | C4orf46 | 0.721153 | 3 | 0 | 3 |
| POLR1A | RFWD3 | 0.721033 | 3 | 0 | 3 |
For details and further investigation, click here
