| Full name: FUS RNA binding protein | Alias Symbol: TLS|FUS1|hnRNP-P2|HNRNPP2 | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 2521 | HGNC ID: HGNC:4010 | Ensembl Gene: ENSG00000089280 | OMIM ID: 137070 |
| Drug and gene relationship at DGIdb | |||
Expression of FUS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FUS | 2521 | 200959_at | 0.7483 | 0.0412 | |
| GSE20347 | FUS | 2521 | 200959_at | 0.9126 | 0.0000 | |
| GSE23400 | FUS | 2521 | 200959_at | 0.8333 | 0.0000 | |
| GSE26886 | FUS | 2521 | 200959_at | 1.0310 | 0.0006 | |
| GSE29001 | FUS | 2521 | 200959_at | 1.3120 | 0.0289 | |
| GSE38129 | FUS | 2521 | 200959_at | 0.9423 | 0.0000 | |
| GSE45670 | FUS | 2521 | 200959_at | 0.6776 | 0.0001 | |
| GSE53622 | FUS | 2521 | 10896 | 0.7147 | 0.0000 | |
| GSE53624 | FUS | 2521 | 10896 | 0.8829 | 0.0000 | |
| GSE63941 | FUS | 2521 | 200959_at | 0.5940 | 0.0310 | |
| GSE77861 | FUS | 2521 | 200959_at | 0.8856 | 0.0017 | |
| GSE97050 | FUS | 2521 | A_23_P106887 | 0.4650 | 0.1801 | |
| SRP007169 | FUS | 2521 | RNAseq | 0.9053 | 0.0028 | |
| SRP008496 | FUS | 2521 | RNAseq | 0.7412 | 0.0001 | |
| SRP064894 | FUS | 2521 | RNAseq | 0.4722 | 0.0009 | |
| SRP133303 | FUS | 2521 | RNAseq | 0.6176 | 0.0001 | |
| SRP159526 | FUS | 2521 | RNAseq | 0.9034 | 0.0048 | |
| SRP193095 | FUS | 2521 | RNAseq | 0.4596 | 0.0001 | |
| SRP219564 | FUS | 2521 | RNAseq | 0.7672 | 0.0019 | |
| TCGA | FUS | 2521 | RNAseq | 0.2206 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by FUS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FUS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FUS | 2521 | 4 | 5 | 21 | |
| GSE20123 | FUS | 2521 | 4 | 4 | 22 | |
| GSE43470 | FUS | 2521 | 3 | 3 | 37 | |
| GSE46452 | FUS | 2521 | 38 | 1 | 20 | |
| GSE47630 | FUS | 2521 | 11 | 7 | 22 | |
| GSE54993 | FUS | 2521 | 2 | 5 | 63 | |
| GSE54994 | FUS | 2521 | 5 | 9 | 39 | |
| GSE60625 | FUS | 2521 | 4 | 0 | 7 | |
| GSE74703 | FUS | 2521 | 3 | 2 | 31 | |
| GSE74704 | FUS | 2521 | 3 | 2 | 15 | |
| TCGA | FUS | 2521 | 20 | 10 | 66 |
Total number of gains: 97; Total number of losses: 48; Total Number of normals: 343.
Somatic mutations of FUS:
Generating mutation plots.
Highly correlated genes for FUS:
Showing top 20/2259 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FUS | FADS1 | 0.80813 | 3 | 0 | 3 |
| FUS | LRRC58 | 0.806732 | 5 | 0 | 5 |
| FUS | CMSS1 | 0.79939 | 6 | 0 | 6 |
| FUS | SPNS1 | 0.796272 | 4 | 0 | 4 |
| FUS | PYCR2 | 0.79516 | 3 | 0 | 3 |
| FUS | RPN1 | 0.770012 | 10 | 0 | 10 |
| FUS | RAB34 | 0.768368 | 3 | 0 | 3 |
| FUS | HEATR1 | 0.762597 | 9 | 0 | 9 |
| FUS | MRPL47 | 0.762165 | 7 | 0 | 7 |
| FUS | EXOC8 | 0.760874 | 3 | 0 | 3 |
| FUS | COLGALT1 | 0.757177 | 10 | 0 | 10 |
| FUS | NIPA1 | 0.7568 | 3 | 0 | 3 |
| FUS | LPCAT1 | 0.754937 | 11 | 0 | 11 |
| FUS | PFDN2 | 0.754837 | 11 | 0 | 11 |
| FUS | TMEM63B | 0.752514 | 4 | 0 | 4 |
| FUS | SLC35B2 | 0.750306 | 3 | 0 | 3 |
| FUS | ARPC1B | 0.746002 | 11 | 0 | 11 |
| FUS | NF1 | 0.744677 | 3 | 0 | 3 |
| FUS | PLXNA1 | 0.744033 | 11 | 0 | 11 |
| FUS | ANAPC1 | 0.743784 | 3 | 0 | 3 |
For details and further investigation, click here
