ISG20L2

 

Full name: interferon stimulated exonuclease gene 20 like 2 Alias Symbol: FLJ12671
Type: protein-coding gene Cytoband: 1q23.1
Entrez ID: 81875 HGNC ID: HGNC:25745 Ensembl Gene: ENSG00000143319 OMIM ID: 611930
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of ISG20L2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ISG20L2 81875 212766_s_at 0.9428 0.0103
GSE20347 ISG20L2 81875 212766_s_at 0.6332 0.0000
GSE23400 ISG20L2 81875 212766_s_at 0.5928 0.0000
GSE26886 ISG20L2 81875 212766_s_at 0.4789 0.0090
GSE29001 ISG20L2 81875 212766_s_at 0.8570 0.0022
GSE38129 ISG20L2 81875 212766_s_at 0.7652 0.0000
GSE45670 ISG20L2 81875 212766_s_at 0.5553 0.0002
GSE53622 ISG20L2 81875 116220 0.5690 0.0000
GSE53624 ISG20L2 81875 116220 0.5690 0.0000
GSE63941 ISG20L2 81875 212766_s_at 0.9402 0.0023
GSE77861 ISG20L2 81875 208114_s_at 0.6304 0.1355
GSE97050 ISG20L2 81875 A_33_P3401322 0.3830 0.2151
SRP007169 ISG20L2 81875 RNAseq 0.3224 0.3218
SRP008496 ISG20L2 81875 RNAseq 0.6015 0.0048
SRP064894 ISG20L2 81875 RNAseq 0.2719 0.0351
SRP133303 ISG20L2 81875 RNAseq 0.4456 0.0008
SRP159526 ISG20L2 81875 RNAseq 0.6899 0.0072
SRP193095 ISG20L2 81875 RNAseq 0.4781 0.0000
SRP219564 ISG20L2 81875 RNAseq 0.3498 0.2871
TCGA ISG20L2 81875 RNAseq 0.1238 0.0161

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ISG20L2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ISG20L2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ISG20L2 81875 12 0 18
GSE20123 ISG20L2 81875 12 0 18
GSE43470 ISG20L2 81875 7 2 34
GSE46452 ISG20L2 81875 2 1 56
GSE47630 ISG20L2 81875 14 0 26
GSE54993 ISG20L2 81875 0 5 65
GSE54994 ISG20L2 81875 16 0 37
GSE60625 ISG20L2 81875 0 0 11
GSE74703 ISG20L2 81875 7 2 27
GSE74704 ISG20L2 81875 6 0 14
TCGA ISG20L2 81875 38 2 56

Total number of gains: 114; Total number of losses: 12; Total Number of normals: 362.  

 

Somatic mutations of ISG20L2:

 

Generating mutation plots.

 

Highly correlated genes for ISG20L2:

 

Showing top 20/1979 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ISG20L2LRRC580.817742404
ISG20L2PYCR20.784472303
ISG20L2DNAJB110.780774505
ISG20L2SLC7A6OS0.768776404
ISG20L2FZD60.768367707
ISG20L2HEATR10.75602612011
ISG20L2EBNA1BP20.750666303
ISG20L2TMEM1380.747311706
ISG20L2MRPL470.7455706
ISG20L2NOP560.744286303
ISG20L2KTI120.741405303
ISG20L2RRP150.7388510010
ISG20L2EXOC80.737199505
ISG20L2PSMG30.736208606
ISG20L2SLC35B20.734313303
ISG20L2C1orf1310.733612807
ISG20L2CBL0.733058404
ISG20L2ILF20.732551009
ISG20L2URB20.73147211011
ISG20L2ANAPC10.730414303

For details and further investigation, click here