TTF1

 

Full name: transcription termination factor 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 9q34.13
Entrez ID: 7270 HGNC ID: HGNC:12397 Ensembl Gene: ENSG00000125482 OMIM ID: 600777
Drug and gene relationship at DGIdb
Screen Evidence:

 

TTF1 involved pathways:

KEGG pathway Description View
hsa04918Thyroid hormone synthesis

 

Expression of TTF1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TTF1 7270 204771_s_at 0.0807 0.9135
GSE20347 TTF1 7270 204771_s_at 0.3985 0.0150
GSE23400 TTF1 7270 204771_s_at 0.4293 0.0000
GSE26886 TTF1 7270 204771_s_at 1.2119 0.0000
GSE29001 TTF1 7270 204771_s_at 0.7132 0.0028
GSE38129 TTF1 7270 204771_s_at 0.3665 0.0053
GSE45670 TTF1 7270 204771_s_at 0.5266 0.0001
GSE53622 TTF1 7270 119532 0.1729 0.0066
GSE53624 TTF1 7270 119532 0.2976 0.0000
GSE63941 TTF1 7270 204771_s_at 1.4771 0.0009
GSE77861 TTF1 7270 204771_s_at 0.7981 0.0036
GSE97050 TTF1 7270 A_33_P3230339 0.0217 0.9216
SRP007169 TTF1 7270 RNAseq 1.0039 0.0531
SRP008496 TTF1 7270 RNAseq 0.8385 0.0616
SRP064894 TTF1 7270 RNAseq 0.3750 0.0079
SRP133303 TTF1 7270 RNAseq 0.0746 0.5333
SRP159526 TTF1 7270 RNAseq 0.3289 0.1691
SRP193095 TTF1 7270 RNAseq 0.2016 0.0380
SRP219564 TTF1 7270 RNAseq -0.1771 0.6019
TCGA TTF1 7270 RNAseq 0.0620 0.3016

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by TTF1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TTF1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TTF1 7270 6 7 17
GSE20123 TTF1 7270 6 7 17
GSE43470 TTF1 7270 4 7 32
GSE46452 TTF1 7270 6 13 40
GSE47630 TTF1 7270 4 15 21
GSE54993 TTF1 7270 3 3 64
GSE54994 TTF1 7270 12 9 32
GSE60625 TTF1 7270 0 0 11
GSE74703 TTF1 7270 4 5 27
GSE74704 TTF1 7270 4 5 11
TCGA TTF1 7270 28 26 42

Total number of gains: 77; Total number of losses: 97; Total Number of normals: 314.  

 

Somatic mutations of TTF1:

 

Generating mutation plots.

 

Highly correlated genes for TTF1:

 

Showing top 20/1075 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TTF1ANAPC40.817631303
TTF1GNA130.794058303
TTF1HES40.792765303
TTF1SNAPC20.789465303
TTF1UHRF1BP10.741908303
TTF1PACSIN20.737932303
TTF1PLEKHH10.736057404
TTF1LTBR0.735118303
TTF1ZNF3620.729853303
TTF1ALKBH60.728489504
TTF1MYH30.72485303
TTF1MAPK1IP1L0.720667303
TTF1ZZEF10.720503303
TTF1PPP6R20.715955303
TTF1STRN40.715343303
TTF1CLUH0.714276303
TTF1FH0.71183303
TTF1PITPNB0.710152303
TTF1MAP3K20.710004605
TTF1ELOVL70.706066303

For details and further investigation, click here