| Full name: integrin subunit beta 4 | Alias Symbol: CD104 | ||
| Type: protein-coding gene | Cytoband: 17q25.1 | ||
| Entrez ID: 3691 | HGNC ID: HGNC:6158 | Ensembl Gene: ENSG00000132470 | OMIM ID: 147557 |
| Drug and gene relationship at DGIdb | |||
ITGB4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of ITGB4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITGB4 | 3691 | 204990_s_at | 1.8453 | 0.0111 | |
| GSE20347 | ITGB4 | 3691 | 204990_s_at | 1.2700 | 0.0000 | |
| GSE23400 | ITGB4 | 3691 | 204990_s_at | 1.3414 | 0.0000 | |
| GSE26886 | ITGB4 | 3691 | 204990_s_at | 1.8120 | 0.0000 | |
| GSE29001 | ITGB4 | 3691 | 204990_s_at | 1.0772 | 0.0003 | |
| GSE38129 | ITGB4 | 3691 | 204990_s_at | 1.1574 | 0.0000 | |
| GSE45670 | ITGB4 | 3691 | 204990_s_at | 1.1032 | 0.0009 | |
| GSE53622 | ITGB4 | 3691 | 129002 | 1.3285 | 0.0000 | |
| GSE53624 | ITGB4 | 3691 | 129002 | 1.3268 | 0.0000 | |
| GSE63941 | ITGB4 | 3691 | 204990_s_at | 4.3307 | 0.0000 | |
| GSE77861 | ITGB4 | 3691 | 204990_s_at | 1.5666 | 0.0115 | |
| GSE97050 | ITGB4 | 3691 | A_33_P3377364 | 1.0120 | 0.0555 | |
| SRP007169 | ITGB4 | 3691 | RNAseq | 2.7872 | 0.0000 | |
| SRP008496 | ITGB4 | 3691 | RNAseq | 2.4224 | 0.0000 | |
| SRP064894 | ITGB4 | 3691 | RNAseq | 1.7310 | 0.0000 | |
| SRP133303 | ITGB4 | 3691 | RNAseq | 1.6008 | 0.0000 | |
| SRP159526 | ITGB4 | 3691 | RNAseq | 1.4818 | 0.0012 | |
| SRP193095 | ITGB4 | 3691 | RNAseq | 1.3378 | 0.0000 | |
| SRP219564 | ITGB4 | 3691 | RNAseq | 1.1683 | 0.0560 | |
| TCGA | ITGB4 | 3691 | RNAseq | 0.3404 | 0.0000 |
Upregulated datasets: 17; Downregulated datasets: 0.
Survival by ITGB4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITGB4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITGB4 | 3691 | 7 | 2 | 21 | |
| GSE20123 | ITGB4 | 3691 | 7 | 2 | 21 | |
| GSE43470 | ITGB4 | 3691 | 5 | 3 | 35 | |
| GSE46452 | ITGB4 | 3691 | 34 | 0 | 25 | |
| GSE47630 | ITGB4 | 3691 | 8 | 1 | 31 | |
| GSE54993 | ITGB4 | 3691 | 2 | 5 | 63 | |
| GSE54994 | ITGB4 | 3691 | 10 | 4 | 39 | |
| GSE60625 | ITGB4 | 3691 | 6 | 0 | 5 | |
| GSE74703 | ITGB4 | 3691 | 5 | 1 | 30 | |
| GSE74704 | ITGB4 | 3691 | 5 | 1 | 14 | |
| TCGA | ITGB4 | 3691 | 32 | 9 | 55 |
Total number of gains: 121; Total number of losses: 28; Total Number of normals: 339.
Somatic mutations of ITGB4:
Generating mutation plots.
Highly correlated genes for ITGB4:
Showing top 20/1967 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITGB4 | ITGA3 | 0.824169 | 13 | 0 | 13 |
| ITGB4 | RTKN | 0.820366 | 8 | 0 | 8 |
| ITGB4 | SOCS7 | 0.795503 | 3 | 0 | 3 |
| ITGB4 | SLC39A3 | 0.794338 | 4 | 0 | 4 |
| ITGB4 | OCIAD2 | 0.786264 | 8 | 0 | 8 |
| ITGB4 | PTK7 | 0.783352 | 11 | 0 | 11 |
| ITGB4 | AGRN | 0.781391 | 13 | 0 | 13 |
| ITGB4 | LAMB3 | 0.778453 | 13 | 0 | 13 |
| ITGB4 | HES4 | 0.776639 | 4 | 0 | 4 |
| ITGB4 | KRTCAP2 | 0.774024 | 5 | 0 | 5 |
| ITGB4 | PLAU | 0.770189 | 12 | 0 | 11 |
| ITGB4 | COL7A1 | 0.766844 | 11 | 0 | 11 |
| ITGB4 | UBE2C | 0.764982 | 12 | 0 | 12 |
| ITGB4 | CCM2 | 0.758246 | 8 | 0 | 8 |
| ITGB4 | SPATA2 | 0.755298 | 3 | 0 | 3 |
| ITGB4 | ITGA6 | 0.74936 | 12 | 0 | 12 |
| ITGB4 | CDH3 | 0.746977 | 11 | 0 | 10 |
| ITGB4 | DNMT1 | 0.744068 | 12 | 0 | 12 |
| ITGB4 | PLXNA1 | 0.742294 | 11 | 0 | 11 |
| ITGB4 | MYBL2 | 0.741787 | 12 | 0 | 12 |
For details and further investigation, click here
