| Full name: 3-hydroxyisobutyryl-CoA hydrolase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q32.2 | ||
| Entrez ID: 26275 | HGNC ID: HGNC:4908 | Ensembl Gene: ENSG00000198130 | OMIM ID: 610690 |
| Drug and gene relationship at DGIdb | |||
Expression of HIBCH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HIBCH | 26275 | 213374_x_at | -0.0160 | 0.9860 | |
| GSE20347 | HIBCH | 26275 | 213374_x_at | -0.9383 | 0.0000 | |
| GSE23400 | HIBCH | 26275 | 213374_x_at | -0.4213 | 0.0011 | |
| GSE26886 | HIBCH | 26275 | 213374_x_at | -1.6018 | 0.0000 | |
| GSE29001 | HIBCH | 26275 | 213374_x_at | -0.6229 | 0.0428 | |
| GSE38129 | HIBCH | 26275 | 213374_x_at | -0.5749 | 0.0012 | |
| GSE45670 | HIBCH | 26275 | 213374_x_at | -0.2681 | 0.3692 | |
| GSE53622 | HIBCH | 26275 | 46171 | -0.1836 | 0.0047 | |
| GSE53624 | HIBCH | 26275 | 46171 | -0.4725 | 0.0000 | |
| GSE63941 | HIBCH | 26275 | 213374_x_at | -0.3005 | 0.5447 | |
| GSE77861 | HIBCH | 26275 | 213374_x_at | -1.3942 | 0.0060 | |
| GSE97050 | HIBCH | 26275 | A_23_P154345 | -0.1210 | 0.5422 | |
| SRP007169 | HIBCH | 26275 | RNAseq | -2.0132 | 0.0000 | |
| SRP008496 | HIBCH | 26275 | RNAseq | -1.8724 | 0.0000 | |
| SRP064894 | HIBCH | 26275 | RNAseq | -1.0120 | 0.0000 | |
| SRP133303 | HIBCH | 26275 | RNAseq | -0.8660 | 0.0000 | |
| SRP159526 | HIBCH | 26275 | RNAseq | -1.2939 | 0.0003 | |
| SRP193095 | HIBCH | 26275 | RNAseq | -1.3242 | 0.0000 | |
| SRP219564 | HIBCH | 26275 | RNAseq | -1.1794 | 0.0000 | |
| TCGA | HIBCH | 26275 | RNAseq | -0.2190 | 0.0012 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by HIBCH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HIBCH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HIBCH | 26275 | 8 | 2 | 20 | |
| GSE20123 | HIBCH | 26275 | 8 | 2 | 20 | |
| GSE43470 | HIBCH | 26275 | 3 | 1 | 39 | |
| GSE46452 | HIBCH | 26275 | 1 | 4 | 54 | |
| GSE47630 | HIBCH | 26275 | 4 | 5 | 31 | |
| GSE54993 | HIBCH | 26275 | 0 | 5 | 65 | |
| GSE54994 | HIBCH | 26275 | 12 | 6 | 35 | |
| GSE60625 | HIBCH | 26275 | 0 | 3 | 8 | |
| GSE74703 | HIBCH | 26275 | 2 | 1 | 33 | |
| GSE74704 | HIBCH | 26275 | 3 | 2 | 15 | |
| TCGA | HIBCH | 26275 | 23 | 7 | 66 |
Total number of gains: 64; Total number of losses: 38; Total Number of normals: 386.
Somatic mutations of HIBCH:
Generating mutation plots.
Highly correlated genes for HIBCH:
Showing top 20/1191 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HIBCH | PRADC1 | 0.807131 | 3 | 0 | 3 |
| HIBCH | HDHD2 | 0.79862 | 4 | 0 | 4 |
| HIBCH | HECW2 | 0.794336 | 3 | 0 | 3 |
| HIBCH | SPAG17 | 0.787224 | 3 | 0 | 3 |
| HIBCH | TMEM234 | 0.769398 | 3 | 0 | 3 |
| HIBCH | SNX12 | 0.76285 | 3 | 0 | 3 |
| HIBCH | TSC22D2 | 0.758753 | 3 | 0 | 3 |
| HIBCH | GTF2A1 | 0.7567 | 3 | 0 | 3 |
| HIBCH | C16orf72 | 0.75431 | 3 | 0 | 3 |
| HIBCH | PTGR1 | 0.752779 | 3 | 0 | 3 |
| HIBCH | RNF149 | 0.749582 | 3 | 0 | 3 |
| HIBCH | VPS25 | 0.748763 | 3 | 0 | 3 |
| HIBCH | KCTD21 | 0.745137 | 4 | 0 | 3 |
| HIBCH | ZNF844 | 0.745036 | 4 | 0 | 3 |
| HIBCH | FAM3B | 0.74124 | 4 | 0 | 4 |
| HIBCH | C5orf66-AS1 | 0.741099 | 4 | 0 | 4 |
| HIBCH | RAB3D | 0.740127 | 5 | 0 | 4 |
| HIBCH | UPRT | 0.739557 | 3 | 0 | 3 |
| HIBCH | PRKAR2A | 0.737286 | 4 | 0 | 4 |
| HIBCH | ANKRD13A | 0.727542 | 4 | 0 | 3 |
For details and further investigation, click here
