| Full name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | Alias Symbol: KIAA1301|NEDL2 | ||
| Type: protein-coding gene | Cytoband: 2q32.3 | ||
| Entrez ID: 57520 | HGNC ID: HGNC:29853 | Ensembl Gene: ENSG00000138411 | OMIM ID: 617245 |
| Drug and gene relationship at DGIdb | |||
Expression of HECW2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HECW2 | 57520 | 232080_at | -0.4419 | 0.4333 | |
| GSE26886 | HECW2 | 57520 | 232080_at | -2.4138 | 0.0000 | |
| GSE45670 | HECW2 | 57520 | 232080_at | -0.8560 | 0.0014 | |
| GSE53622 | HECW2 | 57520 | 46617 | -0.6643 | 0.0000 | |
| GSE53624 | HECW2 | 57520 | 46617 | -1.0351 | 0.0000 | |
| GSE63941 | HECW2 | 57520 | 232080_at | -2.0311 | 0.0158 | |
| GSE77861 | HECW2 | 57520 | 232080_at | -1.1173 | 0.0037 | |
| GSE97050 | HECW2 | 57520 | A_33_P3270311 | -0.0331 | 0.9548 | |
| SRP007169 | HECW2 | 57520 | RNAseq | -0.6593 | 0.2154 | |
| SRP008496 | HECW2 | 57520 | RNAseq | -0.5476 | 0.1041 | |
| SRP064894 | HECW2 | 57520 | RNAseq | -0.3655 | 0.2025 | |
| SRP133303 | HECW2 | 57520 | RNAseq | -0.6671 | 0.0015 | |
| SRP159526 | HECW2 | 57520 | RNAseq | -1.0949 | 0.0000 | |
| SRP193095 | HECW2 | 57520 | RNAseq | -0.5519 | 0.0027 | |
| SRP219564 | HECW2 | 57520 | RNAseq | -0.6349 | 0.1206 | |
| TCGA | HECW2 | 57520 | RNAseq | -0.0109 | 0.9236 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by HECW2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HECW2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HECW2 | 57520 | 9 | 2 | 19 | |
| GSE20123 | HECW2 | 57520 | 9 | 2 | 19 | |
| GSE43470 | HECW2 | 57520 | 3 | 1 | 39 | |
| GSE46452 | HECW2 | 57520 | 1 | 4 | 54 | |
| GSE47630 | HECW2 | 57520 | 4 | 5 | 31 | |
| GSE54993 | HECW2 | 57520 | 0 | 4 | 66 | |
| GSE54994 | HECW2 | 57520 | 11 | 7 | 35 | |
| GSE60625 | HECW2 | 57520 | 0 | 3 | 8 | |
| GSE74703 | HECW2 | 57520 | 2 | 1 | 33 | |
| GSE74704 | HECW2 | 57520 | 4 | 2 | 14 | |
| TCGA | HECW2 | 57520 | 22 | 9 | 65 |
Total number of gains: 65; Total number of losses: 40; Total Number of normals: 383.
Somatic mutations of HECW2:
Generating mutation plots.
Highly correlated genes for HECW2:
Showing top 20/1159 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HECW2 | GNG5 | 0.798941 | 3 | 0 | 3 |
| HECW2 | HIBCH | 0.794336 | 3 | 0 | 3 |
| HECW2 | ZNF717 | 0.762576 | 4 | 0 | 4 |
| HECW2 | MRPL39 | 0.756468 | 3 | 0 | 3 |
| HECW2 | UBA3 | 0.75124 | 3 | 0 | 3 |
| HECW2 | MLKL | 0.749116 | 4 | 0 | 4 |
| HECW2 | ZFC3H1 | 0.748388 | 3 | 0 | 3 |
| HECW2 | APOB | 0.740866 | 3 | 0 | 3 |
| HECW2 | HMGN1 | 0.738502 | 3 | 0 | 3 |
| HECW2 | RHBDF1 | 0.738 | 4 | 0 | 4 |
| HECW2 | EPG5 | 0.734085 | 5 | 0 | 4 |
| HECW2 | KLHL20 | 0.733782 | 3 | 0 | 3 |
| HECW2 | CA13 | 0.732296 | 3 | 0 | 3 |
| HECW2 | SPATS2L | 0.730831 | 3 | 0 | 3 |
| HECW2 | SLC16A6 | 0.727412 | 8 | 0 | 8 |
| HECW2 | SFTA2 | 0.722546 | 4 | 0 | 4 |
| HECW2 | SLC46A2 | 0.718839 | 7 | 0 | 7 |
| HECW2 | GYS2 | 0.717468 | 6 | 0 | 6 |
| HECW2 | CPPED1 | 0.715706 | 7 | 0 | 7 |
| HECW2 | RETSAT | 0.714784 | 4 | 0 | 4 |
For details and further investigation, click here
