| Full name: TSC22 domain family member 2 | Alias Symbol: KIAA0669|TILZ4a|TILZ4b|TILZ4c | ||
| Type: protein-coding gene | Cytoband: 3q25.1 | ||
| Entrez ID: 9819 | HGNC ID: HGNC:29095 | Ensembl Gene: ENSG00000196428 | OMIM ID: 617724 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TSC22D2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TSC22D2 | 9819 | 204094_s_at | 0.0991 | 0.9198 | |
| GSE20347 | TSC22D2 | 9819 | 204094_s_at | -0.0636 | 0.7780 | |
| GSE23400 | TSC22D2 | 9819 | 204094_s_at | -0.4552 | 0.0002 | |
| GSE26886 | TSC22D2 | 9819 | 204094_s_at | -1.8848 | 0.0000 | |
| GSE29001 | TSC22D2 | 9819 | 204094_s_at | -0.1595 | 0.6295 | |
| GSE38129 | TSC22D2 | 9819 | 204094_s_at | -0.3329 | 0.1187 | |
| GSE45670 | TSC22D2 | 9819 | 204094_s_at | -0.1410 | 0.6678 | |
| GSE53622 | TSC22D2 | 9819 | 54765 | -0.6446 | 0.0000 | |
| GSE53624 | TSC22D2 | 9819 | 54765 | -0.4860 | 0.0000 | |
| GSE63941 | TSC22D2 | 9819 | 204094_s_at | -0.6852 | 0.1918 | |
| GSE77861 | TSC22D2 | 9819 | 204094_s_at | 0.0739 | 0.9044 | |
| GSE97050 | TSC22D2 | 9819 | A_23_P92230 | 0.0038 | 0.9898 | |
| SRP007169 | TSC22D2 | 9819 | RNAseq | -2.0700 | 0.0007 | |
| SRP008496 | TSC22D2 | 9819 | RNAseq | -1.6732 | 0.0000 | |
| SRP064894 | TSC22D2 | 9819 | RNAseq | -0.8422 | 0.0033 | |
| SRP133303 | TSC22D2 | 9819 | RNAseq | -0.0168 | 0.9356 | |
| SRP159526 | TSC22D2 | 9819 | RNAseq | -0.3655 | 0.2220 | |
| SRP193095 | TSC22D2 | 9819 | RNAseq | -0.8408 | 0.0003 | |
| SRP219564 | TSC22D2 | 9819 | RNAseq | -1.0283 | 0.0152 | |
| TCGA | TSC22D2 | 9819 | RNAseq | -0.0629 | 0.3880 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by TSC22D2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TSC22D2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TSC22D2 | 9819 | 21 | 0 | 9 | |
| GSE20123 | TSC22D2 | 9819 | 21 | 0 | 9 | |
| GSE43470 | TSC22D2 | 9819 | 23 | 0 | 20 | |
| GSE46452 | TSC22D2 | 9819 | 18 | 2 | 39 | |
| GSE47630 | TSC22D2 | 9819 | 19 | 3 | 18 | |
| GSE54993 | TSC22D2 | 9819 | 1 | 10 | 59 | |
| GSE54994 | TSC22D2 | 9819 | 37 | 1 | 15 | |
| GSE60625 | TSC22D2 | 9819 | 0 | 6 | 5 | |
| GSE74703 | TSC22D2 | 9819 | 20 | 0 | 16 | |
| GSE74704 | TSC22D2 | 9819 | 14 | 0 | 6 | |
| TCGA | TSC22D2 | 9819 | 72 | 1 | 23 |
Total number of gains: 246; Total number of losses: 23; Total Number of normals: 219.
Somatic mutations of TSC22D2:
Generating mutation plots.
Highly correlated genes for TSC22D2:
Showing top 20/336 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TSC22D2 | HIBCH | 0.758753 | 3 | 0 | 3 |
| TSC22D2 | RRM2B | 0.735784 | 3 | 0 | 3 |
| TSC22D2 | DDAH1 | 0.735619 | 3 | 0 | 3 |
| TSC22D2 | MOB3C | 0.731717 | 3 | 0 | 3 |
| TSC22D2 | FAM98A | 0.720689 | 4 | 0 | 3 |
| TSC22D2 | ZNF615 | 0.713592 | 3 | 0 | 3 |
| TSC22D2 | LAMP2 | 0.707988 | 3 | 0 | 3 |
| TSC22D2 | SRGAP2 | 0.706719 | 3 | 0 | 3 |
| TSC22D2 | SUCLG1 | 0.705694 | 3 | 0 | 3 |
| TSC22D2 | SUN1 | 0.701369 | 3 | 0 | 3 |
| TSC22D2 | SNX33 | 0.700244 | 4 | 0 | 4 |
| TSC22D2 | LYSMD3 | 0.693642 | 3 | 0 | 3 |
| TSC22D2 | GPD1L | 0.69352 | 3 | 0 | 3 |
| TSC22D2 | OSBPL8 | 0.689111 | 4 | 0 | 4 |
| TSC22D2 | ZRANB1 | 0.687182 | 3 | 0 | 3 |
| TSC22D2 | CBL | 0.677875 | 4 | 0 | 4 |
| TSC22D2 | VPS37A | 0.676471 | 3 | 0 | 3 |
| TSC22D2 | GPBP1L1 | 0.675534 | 3 | 0 | 3 |
| TSC22D2 | MRPS22 | 0.670256 | 4 | 0 | 3 |
| TSC22D2 | PITHD1 | 0.664348 | 4 | 0 | 3 |
For details and further investigation, click here
