| Full name: homeodomain interacting protein kinase 3 | Alias Symbol: PKY|DYRK6|YAK1|FIST3 | ||
| Type: protein-coding gene | Cytoband: 11p13 | ||
| Entrez ID: 10114 | HGNC ID: HGNC:4915 | Ensembl Gene: ENSG00000110422 | OMIM ID: 604424 |
| Drug and gene relationship at DGIdb | |||
Expression of HIPK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HIPK3 | 10114 | 226297_at | -0.5425 | 0.1637 | |
| GSE20347 | HIPK3 | 10114 | 207764_s_at | 0.0009 | 0.9929 | |
| GSE23400 | HIPK3 | 10114 | 207764_s_at | 0.0346 | 0.5680 | |
| GSE26886 | HIPK3 | 10114 | 226297_at | -0.1945 | 0.2612 | |
| GSE29001 | HIPK3 | 10114 | 213697_at | -0.1181 | 0.5010 | |
| GSE38129 | HIPK3 | 10114 | 207764_s_at | -0.0264 | 0.7281 | |
| GSE45670 | HIPK3 | 10114 | 226297_at | -0.6346 | 0.0000 | |
| GSE53622 | HIPK3 | 10114 | 6870 | -0.9091 | 0.0000 | |
| GSE53624 | HIPK3 | 10114 | 71159 | -0.7785 | 0.0000 | |
| GSE63941 | HIPK3 | 10114 | 226297_at | -0.5831 | 0.0518 | |
| GSE77861 | HIPK3 | 10114 | 226297_at | -0.2782 | 0.4702 | |
| GSE97050 | HIPK3 | 10114 | A_33_P3279545 | -0.5099 | 0.1633 | |
| SRP007169 | HIPK3 | 10114 | RNAseq | -0.8590 | 0.0033 | |
| SRP008496 | HIPK3 | 10114 | RNAseq | -0.4174 | 0.0659 | |
| SRP064894 | HIPK3 | 10114 | RNAseq | -0.3775 | 0.1282 | |
| SRP133303 | HIPK3 | 10114 | RNAseq | -0.3170 | 0.1337 | |
| SRP159526 | HIPK3 | 10114 | RNAseq | -0.8784 | 0.0092 | |
| SRP193095 | HIPK3 | 10114 | RNAseq | -0.6109 | 0.0000 | |
| SRP219564 | HIPK3 | 10114 | RNAseq | -0.5920 | 0.1983 | |
| TCGA | HIPK3 | 10114 | RNAseq | -0.2633 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HIPK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HIPK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HIPK3 | 10114 | 0 | 7 | 23 | |
| GSE20123 | HIPK3 | 10114 | 0 | 6 | 24 | |
| GSE43470 | HIPK3 | 10114 | 2 | 4 | 37 | |
| GSE46452 | HIPK3 | 10114 | 8 | 5 | 46 | |
| GSE47630 | HIPK3 | 10114 | 3 | 10 | 27 | |
| GSE54993 | HIPK3 | 10114 | 3 | 1 | 66 | |
| GSE54994 | HIPK3 | 10114 | 4 | 9 | 40 | |
| GSE60625 | HIPK3 | 10114 | 0 | 0 | 11 | |
| GSE74703 | HIPK3 | 10114 | 2 | 2 | 32 | |
| GSE74704 | HIPK3 | 10114 | 0 | 4 | 16 | |
| TCGA | HIPK3 | 10114 | 13 | 25 | 58 |
Total number of gains: 35; Total number of losses: 73; Total Number of normals: 380.
Somatic mutations of HIPK3:
Generating mutation plots.
Highly correlated genes for HIPK3:
Showing top 20/897 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HIPK3 | CACNB1 | 0.796329 | 3 | 0 | 3 |
| HIPK3 | EIF3M | 0.794514 | 3 | 0 | 3 |
| HIPK3 | DNAJC15 | 0.782888 | 4 | 0 | 4 |
| HIPK3 | NR5A2 | 0.77938 | 3 | 0 | 3 |
| HIPK3 | ITGB3 | 0.779036 | 3 | 0 | 3 |
| HIPK3 | ATF7 | 0.767308 | 3 | 0 | 3 |
| HIPK3 | CFL2 | 0.755919 | 3 | 0 | 3 |
| HIPK3 | FYTTD1 | 0.753908 | 3 | 0 | 3 |
| HIPK3 | PITPNC1 | 0.75289 | 3 | 0 | 3 |
| HIPK3 | C7 | 0.744064 | 4 | 0 | 4 |
| HIPK3 | NLGN4Y | 0.741381 | 3 | 0 | 3 |
| HIPK3 | DNAJC18 | 0.740453 | 3 | 0 | 3 |
| HIPK3 | SLC28A2 | 0.739675 | 3 | 0 | 3 |
| HIPK3 | DAAM1 | 0.734746 | 3 | 0 | 3 |
| HIPK3 | WHAMM | 0.73197 | 3 | 0 | 3 |
| HIPK3 | TJP1 | 0.729257 | 5 | 0 | 5 |
| HIPK3 | FYCO1 | 0.7277 | 6 | 0 | 5 |
| HIPK3 | CHRDL1 | 0.725711 | 3 | 0 | 3 |
| HIPK3 | ARL5A | 0.724509 | 3 | 0 | 3 |
| HIPK3 | TTLL11 | 0.72299 | 3 | 0 | 3 |
For details and further investigation, click here
