| Full name: cofilin 2 | Alias Symbol: NEM7 | ||
| Type: protein-coding gene | Cytoband: 14q13.1 | ||
| Entrez ID: 1073 | HGNC ID: HGNC:1875 | Ensembl Gene: ENSG00000165410 | OMIM ID: 601443 |
| Drug and gene relationship at DGIdb | |||
CFL2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance | |
| hsa04666 | Fc gamma R-mediated phagocytosis | |
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa05133 | Pertussis |
Expression of CFL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CFL2 | 1073 | 224663_s_at | -0.9412 | 0.5030 | |
| GSE26886 | CFL2 | 1073 | 224663_s_at | 0.6487 | 0.2352 | |
| GSE45670 | CFL2 | 1073 | 224663_s_at | -1.5557 | 0.0000 | |
| GSE53622 | CFL2 | 1073 | 39339 | -1.3826 | 0.0000 | |
| GSE53624 | CFL2 | 1073 | 104017 | -1.0331 | 0.0000 | |
| GSE63941 | CFL2 | 1073 | 224663_s_at | -1.1940 | 0.1493 | |
| GSE77861 | CFL2 | 1073 | 224663_s_at | 0.7357 | 0.1167 | |
| GSE97050 | CFL2 | 1073 | A_24_P373152 | -1.6792 | 0.0680 | |
| SRP007169 | CFL2 | 1073 | RNAseq | 1.0626 | 0.0095 | |
| SRP008496 | CFL2 | 1073 | RNAseq | 1.1484 | 0.0001 | |
| SRP064894 | CFL2 | 1073 | RNAseq | -0.7224 | 0.0081 | |
| SRP133303 | CFL2 | 1073 | RNAseq | 0.0852 | 0.8523 | |
| SRP159526 | CFL2 | 1073 | RNAseq | -0.6964 | 0.1007 | |
| SRP193095 | CFL2 | 1073 | RNAseq | 0.6214 | 0.0016 | |
| SRP219564 | CFL2 | 1073 | RNAseq | -0.9228 | 0.2431 | |
| TCGA | CFL2 | 1073 | RNAseq | -0.3862 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 3.
Survival by CFL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CFL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CFL2 | 1073 | 10 | 4 | 16 | |
| GSE20123 | CFL2 | 1073 | 11 | 4 | 15 | |
| GSE43470 | CFL2 | 1073 | 9 | 2 | 32 | |
| GSE46452 | CFL2 | 1073 | 18 | 2 | 39 | |
| GSE47630 | CFL2 | 1073 | 11 | 10 | 19 | |
| GSE54993 | CFL2 | 1073 | 3 | 10 | 57 | |
| GSE54994 | CFL2 | 1073 | 19 | 5 | 29 | |
| GSE60625 | CFL2 | 1073 | 0 | 2 | 9 | |
| GSE74703 | CFL2 | 1073 | 8 | 2 | 26 | |
| GSE74704 | CFL2 | 1073 | 5 | 3 | 12 | |
| TCGA | CFL2 | 1073 | 33 | 14 | 49 |
Total number of gains: 127; Total number of losses: 58; Total Number of normals: 303.
Somatic mutations of CFL2:
Generating mutation plots.
Highly correlated genes for CFL2:
Showing top 20/814 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CFL2 | TNFSF12 | 0.824556 | 3 | 0 | 3 |
| CFL2 | JPH2 | 0.819543 | 3 | 0 | 3 |
| CFL2 | ILK | 0.814689 | 5 | 0 | 5 |
| CFL2 | RBPMS2 | 0.811748 | 5 | 0 | 5 |
| CFL2 | HOXA4 | 0.810284 | 3 | 0 | 3 |
| CFL2 | CLEC3B | 0.809075 | 3 | 0 | 3 |
| CFL2 | CASQ2 | 0.808752 | 5 | 0 | 5 |
| CFL2 | TMOD1 | 0.804615 | 3 | 0 | 3 |
| CFL2 | ANGPTL1 | 0.796763 | 5 | 0 | 5 |
| CFL2 | AOC3 | 0.796479 | 5 | 0 | 5 |
| CFL2 | ITPR1 | 0.791935 | 5 | 0 | 5 |
| CFL2 | ANO5 | 0.791566 | 5 | 0 | 5 |
| CFL2 | MYL9 | 0.791559 | 5 | 0 | 5 |
| CFL2 | LRFN5 | 0.789547 | 4 | 0 | 4 |
| CFL2 | SH3BGR | 0.78704 | 5 | 0 | 5 |
| CFL2 | TCEAL5 | 0.784756 | 3 | 0 | 3 |
| CFL2 | PI16 | 0.783964 | 4 | 0 | 4 |
| CFL2 | RAB11FIP2 | 0.782764 | 4 | 0 | 4 |
| CFL2 | DNAJC15 | 0.781384 | 3 | 0 | 3 |
| CFL2 | PPP1R14A | 0.775254 | 5 | 0 | 5 |
For details and further investigation, click here
