| Full name: nuclear receptor subfamily 5 group A member 2 | Alias Symbol: FTZ-F1beta|hB1F|LRH-1|FTZ-F1|hB1F-2|B1F2|LRH1 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 2494 | HGNC ID: HGNC:7984 | Ensembl Gene: ENSG00000116833 | OMIM ID: 604453 |
| Drug and gene relationship at DGIdb | |||
NR5A2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04950 | Maturity onset diabetes of the young |
Expression of NR5A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NR5A2 | 2494 | 210174_at | -0.1027 | 0.8050 | |
| GSE20347 | NR5A2 | 2494 | 208337_s_at | -0.0732 | 0.3131 | |
| GSE23400 | NR5A2 | 2494 | 208337_s_at | -0.0729 | 0.0034 | |
| GSE26886 | NR5A2 | 2494 | 208337_s_at | -0.2491 | 0.0200 | |
| GSE29001 | NR5A2 | 2494 | 208337_s_at | -0.1573 | 0.3100 | |
| GSE38129 | NR5A2 | 2494 | 210174_at | -0.1333 | 0.4606 | |
| GSE45670 | NR5A2 | 2494 | 210174_at | -0.3860 | 0.0586 | |
| GSE53622 | NR5A2 | 2494 | 8556 | -1.2217 | 0.0000 | |
| GSE53624 | NR5A2 | 2494 | 8556 | -0.9126 | 0.0000 | |
| GSE63941 | NR5A2 | 2494 | 208337_s_at | 0.1792 | 0.6472 | |
| GSE77861 | NR5A2 | 2494 | 208337_s_at | -0.1296 | 0.2630 | |
| GSE97050 | NR5A2 | 2494 | A_23_P161004 | 0.2390 | 0.5278 | |
| SRP064894 | NR5A2 | 2494 | RNAseq | 0.0074 | 0.9846 | |
| SRP133303 | NR5A2 | 2494 | RNAseq | -1.0389 | 0.0000 | |
| SRP159526 | NR5A2 | 2494 | RNAseq | -0.7330 | 0.3692 | |
| SRP219564 | NR5A2 | 2494 | RNAseq | -0.1508 | 0.7698 | |
| TCGA | NR5A2 | 2494 | RNAseq | -0.5916 | 0.0016 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by NR5A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NR5A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NR5A2 | 2494 | 10 | 0 | 20 | |
| GSE20123 | NR5A2 | 2494 | 10 | 0 | 20 | |
| GSE43470 | NR5A2 | 2494 | 6 | 0 | 37 | |
| GSE46452 | NR5A2 | 2494 | 3 | 1 | 55 | |
| GSE47630 | NR5A2 | 2494 | 14 | 0 | 26 | |
| GSE54993 | NR5A2 | 2494 | 0 | 6 | 64 | |
| GSE54994 | NR5A2 | 2494 | 15 | 0 | 38 | |
| GSE60625 | NR5A2 | 2494 | 0 | 0 | 11 | |
| GSE74703 | NR5A2 | 2494 | 6 | 0 | 30 | |
| GSE74704 | NR5A2 | 2494 | 4 | 0 | 16 | |
| TCGA | NR5A2 | 2494 | 42 | 4 | 50 |
Total number of gains: 110; Total number of losses: 11; Total Number of normals: 367.
Somatic mutations of NR5A2:
Generating mutation plots.
Highly correlated genes for NR5A2:
Showing top 20/463 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NR5A2 | HIPK3 | 0.77938 | 3 | 0 | 3 |
| NR5A2 | CRYBA1 | 0.750403 | 3 | 0 | 3 |
| NR5A2 | LILRA4 | 0.723063 | 3 | 0 | 3 |
| NR5A2 | CXCL3 | 0.70525 | 3 | 0 | 3 |
| NR5A2 | ARG2 | 0.700803 | 3 | 0 | 3 |
| NR5A2 | LMAN1 | 0.690687 | 4 | 0 | 3 |
| NR5A2 | ZFP36L2 | 0.690506 | 4 | 0 | 3 |
| NR5A2 | KCNK13 | 0.685714 | 3 | 0 | 3 |
| NR5A2 | CISD3 | 0.683717 | 3 | 0 | 3 |
| NR5A2 | ICAM1 | 0.675677 | 3 | 0 | 3 |
| NR5A2 | CLEC3B | 0.675284 | 3 | 0 | 3 |
| NR5A2 | MAML2 | 0.669812 | 3 | 0 | 3 |
| NR5A2 | MTIF3 | 0.668123 | 3 | 0 | 3 |
| NR5A2 | ST6GALNAC6 | 0.667637 | 3 | 0 | 3 |
| NR5A2 | DOC2B | 0.666693 | 3 | 0 | 3 |
| NR5A2 | TRIM61 | 0.666504 | 4 | 0 | 4 |
| NR5A2 | PEAK1 | 0.665783 | 4 | 0 | 4 |
| NR5A2 | SYN1 | 0.665772 | 4 | 0 | 3 |
| NR5A2 | PZP | 0.664191 | 5 | 0 | 4 |
| NR5A2 | SAMD8 | 0.662517 | 4 | 0 | 4 |
For details and further investigation, click here
