| Full name: high mobility group nucleosomal binding domain 4 | Alias Symbol: NHC | ||
| Type: protein-coding gene | Cytoband: 6p22.2 | ||
| Entrez ID: 10473 | HGNC ID: HGNC:4989 | Ensembl Gene: ENSG00000182952 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of HMGN4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMGN4 | 10473 | 202579_x_at | 0.0631 | 0.9337 | |
| GSE20347 | HMGN4 | 10473 | 209787_s_at | 0.3894 | 0.0786 | |
| GSE23400 | HMGN4 | 10473 | 202579_x_at | 0.5232 | 0.0000 | |
| GSE26886 | HMGN4 | 10473 | 209787_s_at | 0.6578 | 0.0070 | |
| GSE29001 | HMGN4 | 10473 | 202579_x_at | 0.7850 | 0.0006 | |
| GSE38129 | HMGN4 | 10473 | 209787_s_at | 0.2648 | 0.1150 | |
| GSE45670 | HMGN4 | 10473 | 209787_s_at | -0.0309 | 0.9144 | |
| GSE53622 | HMGN4 | 10473 | 14112 | 0.5025 | 0.0000 | |
| GSE53624 | HMGN4 | 10473 | 14112 | 0.6167 | 0.0000 | |
| GSE63941 | HMGN4 | 10473 | 209787_s_at | 0.0393 | 0.9176 | |
| GSE77861 | HMGN4 | 10473 | 202579_x_at | 0.3656 | 0.3147 | |
| GSE97050 | HMGN4 | 10473 | A_24_P397515 | 0.3491 | 0.2151 | |
| SRP007169 | HMGN4 | 10473 | RNAseq | 0.3744 | 0.3068 | |
| SRP008496 | HMGN4 | 10473 | RNAseq | 0.7749 | 0.0055 | |
| SRP064894 | HMGN4 | 10473 | RNAseq | 0.4061 | 0.0054 | |
| SRP133303 | HMGN4 | 10473 | RNAseq | 0.3552 | 0.0023 | |
| SRP159526 | HMGN4 | 10473 | RNAseq | 0.2586 | 0.3906 | |
| SRP193095 | HMGN4 | 10473 | RNAseq | 0.2291 | 0.0705 | |
| SRP219564 | HMGN4 | 10473 | RNAseq | 0.2075 | 0.5497 | |
| TCGA | HMGN4 | 10473 | RNAseq | 0.2078 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HMGN4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMGN4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMGN4 | 10473 | 4 | 2 | 24 | |
| GSE20123 | HMGN4 | 10473 | 4 | 2 | 24 | |
| GSE43470 | HMGN4 | 10473 | 5 | 0 | 38 | |
| GSE46452 | HMGN4 | 10473 | 1 | 10 | 48 | |
| GSE47630 | HMGN4 | 10473 | 8 | 5 | 27 | |
| GSE54993 | HMGN4 | 10473 | 1 | 1 | 68 | |
| GSE54994 | HMGN4 | 10473 | 10 | 4 | 39 | |
| GSE60625 | HMGN4 | 10473 | 0 | 1 | 10 | |
| GSE74703 | HMGN4 | 10473 | 5 | 0 | 31 | |
| GSE74704 | HMGN4 | 10473 | 0 | 1 | 19 | |
| TCGA | HMGN4 | 10473 | 15 | 21 | 60 |
Total number of gains: 53; Total number of losses: 47; Total Number of normals: 388.
Somatic mutations of HMGN4:
Generating mutation plots.
Highly correlated genes for HMGN4:
Showing top 20/1616 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMGN4 | GMCL1 | 0.77144 | 3 | 0 | 3 |
| HMGN4 | NF1 | 0.759376 | 3 | 0 | 3 |
| HMGN4 | CEP170 | 0.742093 | 3 | 0 | 3 |
| HMGN4 | SAAL1 | 0.734866 | 4 | 0 | 4 |
| HMGN4 | ZNF275 | 0.733028 | 6 | 0 | 5 |
| HMGN4 | PYCR2 | 0.725372 | 3 | 0 | 3 |
| HMGN4 | CCNY | 0.712945 | 3 | 0 | 3 |
| HMGN4 | DOCK7 | 0.710439 | 8 | 0 | 7 |
| HMGN4 | SAR1A | 0.710383 | 4 | 0 | 3 |
| HMGN4 | RRP36 | 0.708052 | 4 | 0 | 4 |
| HMGN4 | SCARA3 | 0.704855 | 3 | 0 | 3 |
| HMGN4 | FAM160B1 | 0.704471 | 5 | 0 | 4 |
| HMGN4 | SLC35B2 | 0.700894 | 4 | 0 | 4 |
| HMGN4 | TMTC1 | 0.69737 | 3 | 0 | 3 |
| HMGN4 | KLHL5 | 0.687984 | 7 | 0 | 6 |
| HMGN4 | SOCS4 | 0.686338 | 5 | 0 | 5 |
| HMGN4 | RBM18 | 0.684949 | 4 | 0 | 3 |
| HMGN4 | FADS1 | 0.684753 | 3 | 0 | 3 |
| HMGN4 | SLC25A32 | 0.683426 | 9 | 0 | 9 |
| HMGN4 | GNPDA1 | 0.682998 | 7 | 0 | 6 |
For details and further investigation, click here
