| Full name: kelch like family member 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4p14 | ||
| Entrez ID: 51088 | HGNC ID: HGNC:6356 | Ensembl Gene: ENSG00000109790 | OMIM ID: 608064 |
| Drug and gene relationship at DGIdb | |||
Expression of KLHL5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHL5 | 51088 | 226001_at | 0.3023 | 0.6766 | |
| GSE26886 | KLHL5 | 51088 | 226001_at | 0.9637 | 0.0113 | |
| GSE45670 | KLHL5 | 51088 | 226001_at | 0.0002 | 0.9995 | |
| GSE53622 | KLHL5 | 51088 | 9932 | 0.5797 | 0.0000 | |
| GSE53624 | KLHL5 | 51088 | 9932 | 0.6296 | 0.0000 | |
| GSE63941 | KLHL5 | 51088 | 226001_at | -1.4587 | 0.0066 | |
| GSE77861 | KLHL5 | 51088 | 226001_at | 1.8886 | 0.0011 | |
| GSE97050 | KLHL5 | 51088 | A_24_P17719 | 0.0646 | 0.8758 | |
| SRP007169 | KLHL5 | 51088 | RNAseq | 2.6348 | 0.0000 | |
| SRP008496 | KLHL5 | 51088 | RNAseq | 2.6098 | 0.0000 | |
| SRP064894 | KLHL5 | 51088 | RNAseq | 0.4563 | 0.0316 | |
| SRP133303 | KLHL5 | 51088 | RNAseq | 0.6184 | 0.0010 | |
| SRP159526 | KLHL5 | 51088 | RNAseq | 0.6344 | 0.0122 | |
| SRP193095 | KLHL5 | 51088 | RNAseq | 0.9496 | 0.0000 | |
| SRP219564 | KLHL5 | 51088 | RNAseq | -0.3362 | 0.6172 | |
| TCGA | KLHL5 | 51088 | RNAseq | 0.1279 | 0.0599 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by KLHL5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHL5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHL5 | 51088 | 0 | 16 | 14 | |
| GSE20123 | KLHL5 | 51088 | 0 | 16 | 14 | |
| GSE43470 | KLHL5 | 51088 | 0 | 15 | 28 | |
| GSE46452 | KLHL5 | 51088 | 1 | 36 | 22 | |
| GSE47630 | KLHL5 | 51088 | 1 | 19 | 20 | |
| GSE54993 | KLHL5 | 51088 | 8 | 0 | 62 | |
| GSE54994 | KLHL5 | 51088 | 4 | 10 | 39 | |
| GSE60625 | KLHL5 | 51088 | 0 | 0 | 11 | |
| GSE74703 | KLHL5 | 51088 | 0 | 12 | 24 | |
| GSE74704 | KLHL5 | 51088 | 0 | 9 | 11 | |
| TCGA | KLHL5 | 51088 | 11 | 45 | 40 |
Total number of gains: 25; Total number of losses: 178; Total Number of normals: 285.
Somatic mutations of KLHL5:
Generating mutation plots.
Highly correlated genes for KLHL5:
Showing top 20/1274 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHL5 | ZBED1 | 0.802698 | 3 | 0 | 3 |
| KLHL5 | LSG1 | 0.801781 | 3 | 0 | 3 |
| KLHL5 | UBA2 | 0.785813 | 3 | 0 | 3 |
| KLHL5 | GCLC | 0.785735 | 3 | 0 | 3 |
| KLHL5 | TMF1 | 0.780646 | 3 | 0 | 3 |
| KLHL5 | ATR | 0.775228 | 3 | 0 | 3 |
| KLHL5 | MAP2K5 | 0.769053 | 3 | 0 | 3 |
| KLHL5 | HNRNPA0 | 0.765312 | 3 | 0 | 3 |
| KLHL5 | DNPEP | 0.758854 | 3 | 0 | 3 |
| KLHL5 | PCNP | 0.756944 | 3 | 0 | 3 |
| KLHL5 | DDB1 | 0.753006 | 3 | 0 | 3 |
| KLHL5 | ZDHHC7 | 0.752026 | 4 | 0 | 3 |
| KLHL5 | VMA21 | 0.751914 | 3 | 0 | 3 |
| KLHL5 | ALG2 | 0.750705 | 3 | 0 | 3 |
| KLHL5 | NF1 | 0.738689 | 3 | 0 | 3 |
| KLHL5 | YWHAH | 0.734708 | 6 | 0 | 6 |
| KLHL5 | CLCN7 | 0.732751 | 3 | 0 | 3 |
| KLHL5 | CLP1 | 0.73112 | 3 | 0 | 3 |
| KLHL5 | TRMT6 | 0.73099 | 3 | 0 | 3 |
| KLHL5 | CRKL | 0.729294 | 4 | 0 | 3 |
For details and further investigation, click here
