| Full name: secretion associated Ras related GTPase 1A | Alias Symbol: SAR1|Sara | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 56681 | HGNC ID: HGNC:10534 | Ensembl Gene: ENSG00000079332 | OMIM ID: 607691 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SAR1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SAR1A | 56681 | 201542_at | -0.1669 | 0.4907 | |
| GSE20347 | SAR1A | 56681 | 201542_at | 0.0402 | 0.7750 | |
| GSE23400 | SAR1A | 56681 | 201543_s_at | -0.0626 | 0.5506 | |
| GSE26886 | SAR1A | 56681 | 201542_at | -0.0764 | 0.8125 | |
| GSE29001 | SAR1A | 56681 | 201542_at | 0.0561 | 0.8325 | |
| GSE38129 | SAR1A | 56681 | 201542_at | -0.0859 | 0.5197 | |
| GSE45670 | SAR1A | 56681 | 201542_at | -0.2835 | 0.0190 | |
| GSE53622 | SAR1A | 56681 | 43900 | -0.2477 | 0.0004 | |
| GSE53624 | SAR1A | 56681 | 43900 | 0.2806 | 0.0000 | |
| GSE63941 | SAR1A | 56681 | 201542_at | -1.9614 | 0.0002 | |
| GSE77861 | SAR1A | 56681 | 201542_at | -0.0373 | 0.9150 | |
| GSE97050 | SAR1A | 56681 | A_23_P127175 | 0.1759 | 0.5159 | |
| SRP007169 | SAR1A | 56681 | RNAseq | -0.2273 | 0.5348 | |
| SRP008496 | SAR1A | 56681 | RNAseq | 0.0420 | 0.8294 | |
| SRP064894 | SAR1A | 56681 | RNAseq | -0.0749 | 0.5623 | |
| SRP133303 | SAR1A | 56681 | RNAseq | 0.3913 | 0.0085 | |
| SRP159526 | SAR1A | 56681 | RNAseq | -0.3256 | 0.1073 | |
| SRP193095 | SAR1A | 56681 | RNAseq | -0.2395 | 0.0047 | |
| SRP219564 | SAR1A | 56681 | RNAseq | -0.1236 | 0.5662 | |
| TCGA | SAR1A | 56681 | RNAseq | -0.0385 | 0.4017 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SAR1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SAR1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SAR1A | 56681 | 2 | 4 | 24 | |
| GSE20123 | SAR1A | 56681 | 2 | 3 | 25 | |
| GSE43470 | SAR1A | 56681 | 1 | 7 | 35 | |
| GSE46452 | SAR1A | 56681 | 0 | 11 | 48 | |
| GSE47630 | SAR1A | 56681 | 2 | 14 | 24 | |
| GSE54993 | SAR1A | 56681 | 7 | 0 | 63 | |
| GSE54994 | SAR1A | 56681 | 2 | 12 | 39 | |
| GSE60625 | SAR1A | 56681 | 0 | 0 | 11 | |
| GSE74703 | SAR1A | 56681 | 1 | 4 | 31 | |
| GSE74704 | SAR1A | 56681 | 1 | 1 | 18 | |
| TCGA | SAR1A | 56681 | 9 | 23 | 64 |
Total number of gains: 27; Total number of losses: 79; Total Number of normals: 382.
Somatic mutations of SAR1A:
Generating mutation plots.
Highly correlated genes for SAR1A:
Showing top 20/352 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SAR1A | TM9SF3 | 0.823413 | 3 | 0 | 3 |
| SAR1A | ACRBP | 0.803096 | 3 | 0 | 3 |
| SAR1A | SARNP | 0.774831 | 4 | 0 | 4 |
| SAR1A | TBC1D19 | 0.759822 | 3 | 0 | 3 |
| SAR1A | RBAK | 0.757459 | 3 | 0 | 3 |
| SAR1A | ANG | 0.755931 | 3 | 0 | 3 |
| SAR1A | PDLIM2 | 0.747834 | 3 | 0 | 3 |
| SAR1A | MICA | 0.745399 | 3 | 0 | 3 |
| SAR1A | CHCHD1 | 0.738186 | 3 | 0 | 3 |
| SAR1A | PPIL4 | 0.737558 | 3 | 0 | 3 |
| SAR1A | CASC4 | 0.736039 | 3 | 0 | 3 |
| SAR1A | RALGAPB | 0.724226 | 3 | 0 | 3 |
| SAR1A | HMGN4 | 0.710383 | 4 | 0 | 3 |
| SAR1A | RSPH9 | 0.700693 | 3 | 0 | 3 |
| SAR1A | TMTC1 | 0.697465 | 3 | 0 | 3 |
| SAR1A | SEC11C | 0.697375 | 3 | 0 | 3 |
| SAR1A | INSIG1 | 0.696319 | 3 | 0 | 3 |
| SAR1A | CLCC1 | 0.691856 | 5 | 0 | 4 |
| SAR1A | SGMS2 | 0.690597 | 6 | 0 | 6 |
| SAR1A | PINK1 | 0.688408 | 4 | 0 | 4 |
For details and further investigation, click here
