| Full name: glucosamine-6-phosphate deaminase 1 | Alias Symbol: GNPDA|HLN|GPI|KIAA0060 | ||
| Type: protein-coding gene | Cytoband: 5q31.3 | ||
| Entrez ID: 10007 | HGNC ID: HGNC:4417 | Ensembl Gene: ENSG00000113552 | OMIM ID: 601798 |
| Drug and gene relationship at DGIdb | |||
Expression of GNPDA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GNPDA1 | 10007 | 202382_s_at | 0.4603 | 0.1406 | |
| GSE20347 | GNPDA1 | 10007 | 202382_s_at | 0.7224 | 0.0053 | |
| GSE23400 | GNPDA1 | 10007 | 202382_s_at | 0.4577 | 0.0000 | |
| GSE26886 | GNPDA1 | 10007 | 202382_s_at | 0.5174 | 0.0034 | |
| GSE29001 | GNPDA1 | 10007 | 202382_s_at | 0.8365 | 0.0002 | |
| GSE38129 | GNPDA1 | 10007 | 202382_s_at | 0.8054 | 0.0000 | |
| GSE45670 | GNPDA1 | 10007 | 202382_s_at | 0.5327 | 0.0019 | |
| GSE53622 | GNPDA1 | 10007 | 43252 | 0.7207 | 0.0000 | |
| GSE53624 | GNPDA1 | 10007 | 43252 | 0.8807 | 0.0000 | |
| GSE63941 | GNPDA1 | 10007 | 202382_s_at | 0.4048 | 0.4761 | |
| GSE77861 | GNPDA1 | 10007 | 202382_s_at | 0.5049 | 0.0057 | |
| GSE97050 | GNPDA1 | 10007 | A_23_P144622 | 0.2200 | 0.4339 | |
| SRP007169 | GNPDA1 | 10007 | RNAseq | 1.7937 | 0.0000 | |
| SRP008496 | GNPDA1 | 10007 | RNAseq | 1.8911 | 0.0000 | |
| SRP064894 | GNPDA1 | 10007 | RNAseq | 1.0159 | 0.0000 | |
| SRP133303 | GNPDA1 | 10007 | RNAseq | 0.6899 | 0.0030 | |
| SRP159526 | GNPDA1 | 10007 | RNAseq | 0.7048 | 0.0132 | |
| SRP193095 | GNPDA1 | 10007 | RNAseq | 0.4265 | 0.0009 | |
| SRP219564 | GNPDA1 | 10007 | RNAseq | 1.0662 | 0.0117 | |
| TCGA | GNPDA1 | 10007 | RNAseq | 0.2220 | 0.0001 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by GNPDA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GNPDA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GNPDA1 | 10007 | 1 | 12 | 17 | |
| GSE20123 | GNPDA1 | 10007 | 1 | 12 | 17 | |
| GSE43470 | GNPDA1 | 10007 | 2 | 10 | 31 | |
| GSE46452 | GNPDA1 | 10007 | 0 | 27 | 32 | |
| GSE47630 | GNPDA1 | 10007 | 0 | 20 | 20 | |
| GSE54993 | GNPDA1 | 10007 | 9 | 1 | 60 | |
| GSE54994 | GNPDA1 | 10007 | 2 | 14 | 37 | |
| GSE60625 | GNPDA1 | 10007 | 0 | 0 | 11 | |
| GSE74703 | GNPDA1 | 10007 | 2 | 7 | 27 | |
| GSE74704 | GNPDA1 | 10007 | 1 | 6 | 13 | |
| TCGA | GNPDA1 | 10007 | 3 | 38 | 55 |
Total number of gains: 21; Total number of losses: 147; Total Number of normals: 320.
Somatic mutations of GNPDA1:
Generating mutation plots.
Highly correlated genes for GNPDA1:
Showing top 20/2146 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GNPDA1 | DPYSL2 | 0.7944 | 3 | 0 | 3 |
| GNPDA1 | MEX3B | 0.766086 | 4 | 0 | 4 |
| GNPDA1 | KANSL3 | 0.75821 | 3 | 0 | 3 |
| GNPDA1 | NF1 | 0.742409 | 3 | 0 | 3 |
| GNPDA1 | RAB34 | 0.738166 | 3 | 0 | 3 |
| GNPDA1 | NIPA1 | 0.736998 | 3 | 0 | 3 |
| GNPDA1 | SNAP47 | 0.73559 | 3 | 0 | 3 |
| GNPDA1 | KIAA1586 | 0.731596 | 3 | 0 | 3 |
| GNPDA1 | POC5 | 0.729595 | 6 | 0 | 6 |
| GNPDA1 | C20orf194 | 0.725515 | 3 | 0 | 3 |
| GNPDA1 | APMAP | 0.722865 | 10 | 0 | 9 |
| GNPDA1 | KLHL5 | 0.72225 | 4 | 0 | 3 |
| GNPDA1 | ANGPT2 | 0.72138 | 6 | 0 | 6 |
| GNPDA1 | FMNL2 | 0.718517 | 7 | 0 | 7 |
| GNPDA1 | UPF1 | 0.716649 | 3 | 0 | 3 |
| GNPDA1 | GRAMD4 | 0.716287 | 3 | 0 | 3 |
| GNPDA1 | WDR54 | 0.710408 | 7 | 0 | 6 |
| GNPDA1 | TMEM138 | 0.708019 | 7 | 0 | 7 |
| GNPDA1 | MCMBP | 0.707331 | 3 | 0 | 3 |
| GNPDA1 | SNX10 | 0.707051 | 10 | 0 | 10 |
For details and further investigation, click here
