| Full name: HNF1 homeobox A | Alias Symbol: HNF1|LFB1 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 6927 | HGNC ID: HGNC:11621 | Ensembl Gene: ENSG00000135100 | OMIM ID: 142410 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
HNF1A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04550 | Signaling pathways regulating pluripotency of stem cells | |
| hsa04950 | Maturity onset diabetes of the young |
Expression of HNF1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HNF1A | 6927 | 210515_at | -0.1109 | 0.7247 | |
| GSE20347 | HNF1A | 6927 | 210515_at | -0.1631 | 0.1068 | |
| GSE23400 | HNF1A | 6927 | 210515_at | -0.2008 | 0.0000 | |
| GSE26886 | HNF1A | 6927 | 210515_at | 0.1388 | 0.2796 | |
| GSE29001 | HNF1A | 6927 | 210515_at | -0.0832 | 0.6624 | |
| GSE38129 | HNF1A | 6927 | 210515_at | -0.2541 | 0.0006 | |
| GSE45670 | HNF1A | 6927 | 210515_at | 0.0435 | 0.6794 | |
| GSE53622 | HNF1A | 6927 | 20122 | -0.3101 | 0.0000 | |
| GSE53624 | HNF1A | 6927 | 20122 | -0.8548 | 0.0000 | |
| GSE63941 | HNF1A | 6927 | 210515_at | -0.0062 | 0.9775 | |
| GSE77861 | HNF1A | 6927 | 210515_at | -0.1205 | 0.4450 | |
| GSE97050 | HNF1A | 6927 | A_33_P3328312 | 0.0493 | 0.9126 | |
| TCGA | HNF1A | 6927 | RNAseq | -1.5393 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HNF1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HNF1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HNF1A | 6927 | 6 | 2 | 22 | |
| GSE20123 | HNF1A | 6927 | 6 | 2 | 22 | |
| GSE43470 | HNF1A | 6927 | 2 | 2 | 39 | |
| GSE46452 | HNF1A | 6927 | 9 | 1 | 49 | |
| GSE47630 | HNF1A | 6927 | 9 | 3 | 28 | |
| GSE54993 | HNF1A | 6927 | 0 | 5 | 65 | |
| GSE54994 | HNF1A | 6927 | 6 | 7 | 40 | |
| GSE60625 | HNF1A | 6927 | 0 | 0 | 11 | |
| GSE74703 | HNF1A | 6927 | 2 | 1 | 33 | |
| GSE74704 | HNF1A | 6927 | 3 | 2 | 15 | |
| TCGA | HNF1A | 6927 | 20 | 12 | 64 |
Total number of gains: 63; Total number of losses: 37; Total Number of normals: 388.
Somatic mutations of HNF1A:
Generating mutation plots.
Highly correlated genes for HNF1A:
Showing top 20/1009 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HNF1A | PF4 | 0.724651 | 4 | 0 | 4 |
| HNF1A | EFCAB13 | 0.720554 | 3 | 0 | 3 |
| HNF1A | ART1 | 0.717502 | 4 | 0 | 4 |
| HNF1A | LINC00165 | 0.702319 | 3 | 0 | 3 |
| HNF1A | ZDHHC1 | 0.691351 | 3 | 0 | 3 |
| HNF1A | UMOD | 0.687185 | 5 | 0 | 5 |
| HNF1A | LINC00482 | 0.679892 | 3 | 0 | 3 |
| HNF1A | TPSD1 | 0.678575 | 8 | 0 | 8 |
| HNF1A | IL9R | 0.677916 | 5 | 0 | 5 |
| HNF1A | AMER2 | 0.67663 | 3 | 0 | 3 |
| HNF1A | LIMS2 | 0.675891 | 3 | 0 | 3 |
| HNF1A | OR4D2 | 0.675089 | 3 | 0 | 3 |
| HNF1A | IFNA21 | 0.665741 | 5 | 0 | 5 |
| HNF1A | LMAN1L | 0.665288 | 6 | 0 | 6 |
| HNF1A | CNTD2 | 0.660611 | 6 | 0 | 5 |
| HNF1A | DUSP21 | 0.660491 | 5 | 0 | 5 |
| HNF1A | CEACAM21 | 0.65982 | 6 | 0 | 6 |
| HNF1A | DRD2 | 0.659066 | 6 | 0 | 5 |
| HNF1A | CSH1 | 0.658938 | 7 | 0 | 7 |
| HNF1A | SSPO | 0.658308 | 4 | 0 | 4 |
For details and further investigation, click here
