| Full name: hepatocyte nuclear factor 4 gamma | Alias Symbol: NR2A2 | ||
| Type: protein-coding gene | Cytoband: 8q21.13 | ||
| Entrez ID: 3174 | HGNC ID: HGNC:5026 | Ensembl Gene: ENSG00000164749 | OMIM ID: 605966 |
| Drug and gene relationship at DGIdb | |||
HNF4G involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04950 | Maturity onset diabetes of the young |
Expression of HNF4G:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HNF4G | 3174 | 207456_at | 0.1483 | 0.5701 | |
| GSE20347 | HNF4G | 3174 | 207456_at | 0.0276 | 0.6421 | |
| GSE23400 | HNF4G | 3174 | 207456_at | -0.0248 | 0.2640 | |
| GSE26886 | HNF4G | 3174 | 232271_at | 0.5155 | 0.0210 | |
| GSE29001 | HNF4G | 3174 | 207456_at | -0.0358 | 0.8506 | |
| GSE38129 | HNF4G | 3174 | 207456_at | 0.0015 | 0.9834 | |
| GSE45670 | HNF4G | 3174 | 232271_at | 0.1269 | 0.4507 | |
| GSE53622 | HNF4G | 3174 | 140316 | -0.8458 | 0.0061 | |
| GSE53624 | HNF4G | 3174 | 140316 | -0.7365 | 0.0007 | |
| GSE63941 | HNF4G | 3174 | 232271_at | 0.8856 | 0.2556 | |
| GSE77861 | HNF4G | 3174 | 207456_at | 0.0070 | 0.9441 | |
| GSE97050 | HNF4G | 3174 | A_33_P3286492 | -0.0605 | 0.8568 | |
| SRP133303 | HNF4G | 3174 | RNAseq | 1.0902 | 0.0282 | |
| SRP159526 | HNF4G | 3174 | RNAseq | 0.1990 | 0.6942 | |
| TCGA | HNF4G | 3174 | RNAseq | -1.1579 | 0.0071 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by HNF4G expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HNF4G:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HNF4G | 3174 | 16 | 1 | 13 | |
| GSE20123 | HNF4G | 3174 | 17 | 1 | 12 | |
| GSE43470 | HNF4G | 3174 | 19 | 1 | 23 | |
| GSE46452 | HNF4G | 3174 | 22 | 0 | 37 | |
| GSE47630 | HNF4G | 3174 | 23 | 0 | 17 | |
| GSE54993 | HNF4G | 3174 | 0 | 19 | 51 | |
| GSE54994 | HNF4G | 3174 | 30 | 0 | 23 | |
| GSE60625 | HNF4G | 3174 | 0 | 4 | 7 | |
| GSE74703 | HNF4G | 3174 | 16 | 1 | 19 | |
| GSE74704 | HNF4G | 3174 | 11 | 0 | 9 | |
| TCGA | HNF4G | 3174 | 52 | 2 | 42 |
Total number of gains: 206; Total number of losses: 29; Total Number of normals: 253.
Somatic mutations of HNF4G:
Generating mutation plots.
Highly correlated genes for HNF4G:
Showing top 20/346 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HNF4G | GNS | 0.733682 | 3 | 0 | 3 |
| HNF4G | TMED8 | 0.725919 | 3 | 0 | 3 |
| HNF4G | RNF19A | 0.718447 | 3 | 0 | 3 |
| HNF4G | STARD3NL | 0.715307 | 3 | 0 | 3 |
| HNF4G | C7orf50 | 0.713062 | 3 | 0 | 3 |
| HNF4G | ATG10 | 0.711962 | 5 | 0 | 5 |
| HNF4G | RSBN1L | 0.706721 | 3 | 0 | 3 |
| HNF4G | OR3A1 | 0.704558 | 3 | 0 | 3 |
| HNF4G | GNPDA1 | 0.703811 | 3 | 0 | 3 |
| HNF4G | CLCA1 | 0.699012 | 3 | 0 | 3 |
| HNF4G | C1orf159 | 0.695097 | 3 | 0 | 3 |
| HNF4G | MLANA | 0.693988 | 3 | 0 | 3 |
| HNF4G | KAT7 | 0.69114 | 3 | 0 | 3 |
| HNF4G | ATRNL1 | 0.686444 | 3 | 0 | 3 |
| HNF4G | PDS5B | 0.685919 | 3 | 0 | 3 |
| HNF4G | EPX | 0.683912 | 3 | 0 | 3 |
| HNF4G | PPARA | 0.680178 | 3 | 0 | 3 |
| HNF4G | NDRG3 | 0.676449 | 3 | 0 | 3 |
| HNF4G | PWWP2A | 0.676387 | 4 | 0 | 3 |
| HNF4G | ASH1L | 0.673233 | 4 | 0 | 4 |
For details and further investigation, click here
