| Full name: NDRG family member 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20q11.23 | ||
| Entrez ID: 57446 | HGNC ID: HGNC:14462 | Ensembl Gene: ENSG00000101079 | OMIM ID: 605273 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NDRG3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NDRG3 | 57446 | 217286_s_at | 0.1983 | 0.5272 | |
| GSE20347 | NDRG3 | 57446 | 217286_s_at | -0.1164 | 0.5044 | |
| GSE23400 | NDRG3 | 57446 | 217286_s_at | 0.0317 | 0.6317 | |
| GSE26886 | NDRG3 | 57446 | 217286_s_at | 0.5845 | 0.0212 | |
| GSE29001 | NDRG3 | 57446 | 217286_s_at | 0.0883 | 0.7476 | |
| GSE38129 | NDRG3 | 57446 | 217286_s_at | -0.1318 | 0.2950 | |
| GSE45670 | NDRG3 | 57446 | 217286_s_at | -0.0593 | 0.7463 | |
| GSE53622 | NDRG3 | 57446 | 49882 | 0.1142 | 0.1259 | |
| GSE53624 | NDRG3 | 57446 | 49882 | -0.1708 | 0.0090 | |
| GSE63941 | NDRG3 | 57446 | 217286_s_at | -0.4999 | 0.4455 | |
| GSE77861 | NDRG3 | 57446 | 217286_s_at | -0.1562 | 0.6439 | |
| GSE97050 | NDRG3 | 57446 | A_24_P185604 | -0.5267 | 0.1518 | |
| SRP007169 | NDRG3 | 57446 | RNAseq | -0.2797 | 0.4241 | |
| SRP008496 | NDRG3 | 57446 | RNAseq | -0.0636 | 0.7818 | |
| SRP064894 | NDRG3 | 57446 | RNAseq | 0.1624 | 0.2533 | |
| SRP133303 | NDRG3 | 57446 | RNAseq | -0.3171 | 0.0406 | |
| SRP159526 | NDRG3 | 57446 | RNAseq | -0.0837 | 0.6726 | |
| SRP193095 | NDRG3 | 57446 | RNAseq | -0.0708 | 0.5086 | |
| SRP219564 | NDRG3 | 57446 | RNAseq | 0.5085 | 0.1072 | |
| TCGA | NDRG3 | 57446 | RNAseq | 0.1109 | 0.0405 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NDRG3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NDRG3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NDRG3 | 57446 | 14 | 2 | 14 | |
| GSE20123 | NDRG3 | 57446 | 14 | 2 | 14 | |
| GSE43470 | NDRG3 | 57446 | 12 | 0 | 31 | |
| GSE46452 | NDRG3 | 57446 | 29 | 0 | 30 | |
| GSE47630 | NDRG3 | 57446 | 24 | 0 | 16 | |
| GSE54993 | NDRG3 | 57446 | 0 | 17 | 53 | |
| GSE54994 | NDRG3 | 57446 | 24 | 0 | 29 | |
| GSE60625 | NDRG3 | 57446 | 0 | 0 | 11 | |
| GSE74703 | NDRG3 | 57446 | 11 | 0 | 25 | |
| GSE74704 | NDRG3 | 57446 | 10 | 1 | 9 | |
| TCGA | NDRG3 | 57446 | 49 | 3 | 44 |
Total number of gains: 187; Total number of losses: 25; Total Number of normals: 276.
Somatic mutations of NDRG3:
Generating mutation plots.
Highly correlated genes for NDRG3:
Showing top 20/231 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NDRG3 | FAM200B | 0.786111 | 3 | 0 | 3 |
| NDRG3 | ZNF764 | 0.74954 | 3 | 0 | 3 |
| NDRG3 | LZIC | 0.736941 | 3 | 0 | 3 |
| NDRG3 | DDX27 | 0.734717 | 3 | 0 | 3 |
| NDRG3 | DDX54 | 0.731233 | 3 | 0 | 3 |
| NDRG3 | VPS37C | 0.730722 | 3 | 0 | 3 |
| NDRG3 | DMAP1 | 0.719306 | 3 | 0 | 3 |
| NDRG3 | MRPS18B | 0.717152 | 4 | 0 | 4 |
| NDRG3 | NFXL1 | 0.708322 | 3 | 0 | 3 |
| NDRG3 | ZNF121 | 0.703488 | 3 | 0 | 3 |
| NDRG3 | SBNO1 | 0.702004 | 3 | 0 | 3 |
| NDRG3 | MRPL16 | 0.701237 | 3 | 0 | 3 |
| NDRG3 | SENP6 | 0.700496 | 3 | 0 | 3 |
| NDRG3 | ZCCHC14 | 0.700379 | 3 | 0 | 3 |
| NDRG3 | UHRF1BP1L | 0.69376 | 3 | 0 | 3 |
| NDRG3 | PET117 | 0.691577 | 3 | 0 | 3 |
| NDRG3 | HTATSF1 | 0.685141 | 3 | 0 | 3 |
| NDRG3 | TTC4 | 0.68402 | 3 | 0 | 3 |
| NDRG3 | ZNF354B | 0.679826 | 3 | 0 | 3 |
| NDRG3 | RPS14 | 0.677836 | 4 | 0 | 3 |
For details and further investigation, click here
