| Full name: glucosamine (N-acetyl)-6-sulfatase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q14.3 | ||
| Entrez ID: 2799 | HGNC ID: HGNC:4422 | Ensembl Gene: ENSG00000135677 | OMIM ID: 607664 |
| Drug and gene relationship at DGIdb | |||
Expression of GNS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GNS | 2799 | 212334_at | 0.3141 | 0.3907 | |
| GSE20347 | GNS | 2799 | 212334_at | 0.4903 | 0.0002 | |
| GSE23400 | GNS | 2799 | 212334_at | 0.4704 | 0.0000 | |
| GSE26886 | GNS | 2799 | 212334_at | 1.2026 | 0.0000 | |
| GSE29001 | GNS | 2799 | 212334_at | 0.4299 | 0.0500 | |
| GSE38129 | GNS | 2799 | 212334_at | 0.4521 | 0.0316 | |
| GSE45670 | GNS | 2799 | 212334_at | -0.0277 | 0.8970 | |
| GSE63941 | GNS | 2799 | 212334_at | -1.7016 | 0.0028 | |
| GSE77861 | GNS | 2799 | 212334_at | 0.7108 | 0.0176 | |
| GSE97050 | GNS | 2799 | A_33_P3261167 | 0.1544 | 0.5076 | |
| SRP007169 | GNS | 2799 | RNAseq | 1.0942 | 0.0038 | |
| SRP008496 | GNS | 2799 | RNAseq | 1.1989 | 0.0000 | |
| SRP064894 | GNS | 2799 | RNAseq | 1.1434 | 0.0000 | |
| SRP133303 | GNS | 2799 | RNAseq | 0.9957 | 0.0000 | |
| SRP159526 | GNS | 2799 | RNAseq | 0.7707 | 0.0004 | |
| SRP193095 | GNS | 2799 | RNAseq | 0.6980 | 0.0000 | |
| SRP219564 | GNS | 2799 | RNAseq | 0.8519 | 0.1291 | |
| TCGA | GNS | 2799 | RNAseq | -0.1422 | 0.0016 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by GNS expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GNS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GNS | 2799 | 5 | 2 | 23 | |
| GSE20123 | GNS | 2799 | 5 | 1 | 24 | |
| GSE43470 | GNS | 2799 | 5 | 0 | 38 | |
| GSE46452 | GNS | 2799 | 11 | 0 | 48 | |
| GSE47630 | GNS | 2799 | 10 | 2 | 28 | |
| GSE54993 | GNS | 2799 | 0 | 6 | 64 | |
| GSE54994 | GNS | 2799 | 8 | 1 | 44 | |
| GSE60625 | GNS | 2799 | 0 | 0 | 11 | |
| GSE74703 | GNS | 2799 | 5 | 0 | 31 | |
| GSE74704 | GNS | 2799 | 4 | 1 | 15 | |
| TCGA | GNS | 2799 | 20 | 9 | 67 |
Total number of gains: 73; Total number of losses: 22; Total Number of normals: 393.
Somatic mutations of GNS:
Generating mutation plots.
Highly correlated genes for GNS:
Showing top 20/1428 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GNS | ZBED1 | 0.855162 | 3 | 0 | 3 |
| GNS | ALKBH6 | 0.842625 | 3 | 0 | 3 |
| GNS | MAP3K2 | 0.821995 | 3 | 0 | 3 |
| GNS | GZF1 | 0.820766 | 3 | 0 | 3 |
| GNS | DNTTIP1 | 0.815473 | 3 | 0 | 3 |
| GNS | ACBD6 | 0.806812 | 3 | 0 | 3 |
| GNS | WDR81 | 0.783559 | 4 | 0 | 4 |
| GNS | KLHL13 | 0.78354 | 3 | 0 | 3 |
| GNS | THAP5 | 0.779659 | 3 | 0 | 3 |
| GNS | SMCR8 | 0.777996 | 4 | 0 | 4 |
| GNS | PTPN4 | 0.777355 | 3 | 0 | 3 |
| GNS | TIMP1 | 0.776775 | 9 | 0 | 9 |
| GNS | PTGFRN | 0.776108 | 3 | 0 | 3 |
| GNS | TMC7 | 0.773511 | 3 | 0 | 3 |
| GNS | FMNL2 | 0.766146 | 3 | 0 | 3 |
| GNS | IRF2BP2 | 0.765457 | 3 | 0 | 3 |
| GNS | CASC4 | 0.762432 | 4 | 0 | 4 |
| GNS | CRLS1 | 0.761704 | 3 | 0 | 3 |
| GNS | PDE7A | 0.759511 | 3 | 0 | 3 |
| GNS | FIP1L1 | 0.756508 | 3 | 0 | 3 |
For details and further investigation, click here
