| Full name: sclerostin domain containing 1 | Alias Symbol: DKFZp564D206|USAG1|DAND7 | ||
| Type: protein-coding gene | Cytoband: 7p21.2 | ||
| Entrez ID: 25928 | HGNC ID: HGNC:21748 | Ensembl Gene: ENSG00000171243 | OMIM ID: 609675 |
| Drug and gene relationship at DGIdb | |||
Expression of SOSTDC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOSTDC1 | 25928 | 213456_at | -1.0481 | 0.5780 | |
| GSE20347 | SOSTDC1 | 25928 | 213456_at | 0.7964 | 0.2325 | |
| GSE23400 | SOSTDC1 | 25928 | 213456_at | 0.4427 | 0.0341 | |
| GSE26886 | SOSTDC1 | 25928 | 213456_at | -0.0989 | 0.9090 | |
| GSE29001 | SOSTDC1 | 25928 | 213456_at | 0.5966 | 0.4236 | |
| GSE38129 | SOSTDC1 | 25928 | 213456_at | 0.9052 | 0.0764 | |
| GSE45670 | SOSTDC1 | 25928 | 213456_at | -0.3811 | 0.6841 | |
| GSE53622 | SOSTDC1 | 25928 | 112730 | 0.2026 | 0.6220 | |
| GSE53624 | SOSTDC1 | 25928 | 112730 | 0.4015 | 0.1638 | |
| GSE63941 | SOSTDC1 | 25928 | 213456_at | 1.9377 | 0.3001 | |
| GSE77861 | SOSTDC1 | 25928 | 213456_at | 1.1563 | 0.1328 | |
| GSE97050 | SOSTDC1 | 25928 | A_23_P145841 | -0.6223 | 0.2497 | |
| SRP133303 | SOSTDC1 | 25928 | RNAseq | 0.8045 | 0.2457 | |
| SRP159526 | SOSTDC1 | 25928 | RNAseq | 3.7752 | 0.0000 | |
| SRP193095 | SOSTDC1 | 25928 | RNAseq | -0.6833 | 0.1323 | |
| SRP219564 | SOSTDC1 | 25928 | RNAseq | 1.3292 | 0.2829 | |
| TCGA | SOSTDC1 | 25928 | RNAseq | -0.4081 | 0.3324 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SOSTDC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOSTDC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOSTDC1 | 25928 | 14 | 2 | 14 | |
| GSE20123 | SOSTDC1 | 25928 | 14 | 2 | 14 | |
| GSE43470 | SOSTDC1 | 25928 | 5 | 0 | 38 | |
| GSE46452 | SOSTDC1 | 25928 | 11 | 1 | 47 | |
| GSE47630 | SOSTDC1 | 25928 | 9 | 1 | 30 | |
| GSE54993 | SOSTDC1 | 25928 | 0 | 6 | 64 | |
| GSE54994 | SOSTDC1 | 25928 | 21 | 1 | 31 | |
| GSE60625 | SOSTDC1 | 25928 | 0 | 0 | 11 | |
| GSE74703 | SOSTDC1 | 25928 | 5 | 0 | 31 | |
| GSE74704 | SOSTDC1 | 25928 | 8 | 2 | 10 | |
| TCGA | SOSTDC1 | 25928 | 56 | 5 | 35 |
Total number of gains: 143; Total number of losses: 20; Total Number of normals: 325.
Somatic mutations of SOSTDC1:
Generating mutation plots.
Highly correlated genes for SOSTDC1:
Showing top 20/42 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOSTDC1 | NCR3LG1 | 0.683442 | 3 | 0 | 3 |
| SOSTDC1 | SOX2-OT | 0.675019 | 4 | 0 | 4 |
| SOSTDC1 | CD9 | 0.634377 | 3 | 0 | 3 |
| SOSTDC1 | ZNRF3 | 0.628105 | 3 | 0 | 3 |
| SOSTDC1 | DMRT2 | 0.596872 | 4 | 0 | 3 |
| SOSTDC1 | MRPL11 | 0.58894 | 4 | 0 | 3 |
| SOSTDC1 | HOGA1 | 0.588411 | 3 | 0 | 3 |
| SOSTDC1 | FAXC | 0.580878 | 4 | 0 | 3 |
| SOSTDC1 | MORF4L1 | 0.574968 | 3 | 0 | 3 |
| SOSTDC1 | ROCK2 | 0.569778 | 3 | 0 | 3 |
| SOSTDC1 | TMEM246 | 0.568537 | 4 | 0 | 3 |
| SOSTDC1 | CDH13 | 0.561028 | 5 | 0 | 4 |
| SOSTDC1 | PM20D2 | 0.557955 | 4 | 0 | 3 |
| SOSTDC1 | HOMEZ | 0.553994 | 4 | 0 | 3 |
| SOSTDC1 | WIF1 | 0.55161 | 3 | 0 | 3 |
| SOSTDC1 | SOX2 | 0.547578 | 6 | 0 | 4 |
| SOSTDC1 | NT5DC1 | 0.545825 | 5 | 0 | 3 |
| SOSTDC1 | MTFMT | 0.545089 | 4 | 0 | 3 |
| SOSTDC1 | SORL1 | 0.543187 | 7 | 0 | 4 |
| SOSTDC1 | KCNE3 | 0.53971 | 5 | 0 | 3 |
For details and further investigation, click here
