| Full name: ORMDL sphingolipid biosynthesis regulator 2 | Alias Symbol: HSPC160|adoplin-2|MST095|MSTP095 | ||
| Type: protein-coding gene | Cytoband: 12q13.2 | ||
| Entrez ID: 29095 | HGNC ID: HGNC:16037 | Ensembl Gene: ENSG00000123353 | OMIM ID: 610074 |
| Drug and gene relationship at DGIdb | |||
Expression of ORMDL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ORMDL2 | 29095 | 218556_at | -0.6448 | 0.2772 | |
| GSE20347 | ORMDL2 | 29095 | 218556_at | -1.0394 | 0.0000 | |
| GSE23400 | ORMDL2 | 29095 | 218556_at | -0.3700 | 0.0005 | |
| GSE26886 | ORMDL2 | 29095 | 218556_at | -1.2747 | 0.0000 | |
| GSE29001 | ORMDL2 | 29095 | 218556_at | -1.0190 | 0.0009 | |
| GSE38129 | ORMDL2 | 29095 | 218556_at | -0.4245 | 0.0779 | |
| GSE45670 | ORMDL2 | 29095 | 218556_at | -0.0246 | 0.9226 | |
| GSE63941 | ORMDL2 | 29095 | 218556_at | 0.5529 | 0.1645 | |
| GSE77861 | ORMDL2 | 29095 | 218556_at | -0.5310 | 0.0195 | |
| GSE97050 | ORMDL2 | 29095 | A_23_P87500 | 0.3242 | 0.4854 | |
| SRP007169 | ORMDL2 | 29095 | RNAseq | -1.5731 | 0.0000 | |
| SRP008496 | ORMDL2 | 29095 | RNAseq | -1.3937 | 0.0000 | |
| SRP064894 | ORMDL2 | 29095 | RNAseq | -0.3864 | 0.1308 | |
| SRP133303 | ORMDL2 | 29095 | RNAseq | 0.1262 | 0.5174 | |
| SRP159526 | ORMDL2 | 29095 | RNAseq | -0.8647 | 0.0002 | |
| SRP193095 | ORMDL2 | 29095 | RNAseq | -0.6655 | 0.0000 | |
| SRP219564 | ORMDL2 | 29095 | RNAseq | -0.8152 | 0.1058 | |
| TCGA | ORMDL2 | 29095 | RNAseq | 0.2107 | 0.0033 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by ORMDL2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ORMDL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ORMDL2 | 29095 | 6 | 1 | 23 | |
| GSE20123 | ORMDL2 | 29095 | 6 | 1 | 23 | |
| GSE43470 | ORMDL2 | 29095 | 4 | 0 | 39 | |
| GSE46452 | ORMDL2 | 29095 | 8 | 1 | 50 | |
| GSE47630 | ORMDL2 | 29095 | 10 | 2 | 28 | |
| GSE54993 | ORMDL2 | 29095 | 0 | 5 | 65 | |
| GSE54994 | ORMDL2 | 29095 | 4 | 1 | 48 | |
| GSE60625 | ORMDL2 | 29095 | 0 | 0 | 11 | |
| GSE74703 | ORMDL2 | 29095 | 4 | 0 | 32 | |
| GSE74704 | ORMDL2 | 29095 | 4 | 1 | 15 | |
| TCGA | ORMDL2 | 29095 | 15 | 10 | 71 |
Total number of gains: 61; Total number of losses: 22; Total Number of normals: 405.
Somatic mutations of ORMDL2:
Generating mutation plots.
Highly correlated genes for ORMDL2:
Showing top 20/1600 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ORMDL2 | RASSF5 | 0.83563 | 4 | 0 | 4 |
| ORMDL2 | MFSD5 | 0.812174 | 9 | 0 | 9 |
| ORMDL2 | RER1 | 0.778277 | 8 | 0 | 8 |
| ORMDL2 | FBXL16 | 0.775386 | 4 | 0 | 4 |
| ORMDL2 | RHBDL2 | 0.771323 | 4 | 0 | 4 |
| ORMDL2 | VPS25 | 0.767896 | 5 | 0 | 4 |
| ORMDL2 | SYAP1 | 0.767434 | 5 | 0 | 5 |
| ORMDL2 | GALE | 0.766948 | 9 | 0 | 9 |
| ORMDL2 | GRPEL2 | 0.76678 | 5 | 0 | 5 |
| ORMDL2 | CAPNS2 | 0.765777 | 4 | 0 | 4 |
| ORMDL2 | DEGS2 | 0.764867 | 4 | 0 | 3 |
| ORMDL2 | STX19 | 0.763909 | 3 | 0 | 3 |
| ORMDL2 | PDCD6IP | 0.761859 | 9 | 0 | 9 |
| ORMDL2 | CNFN | 0.761711 | 4 | 0 | 4 |
| ORMDL2 | ZDHHC5 | 0.761586 | 3 | 0 | 3 |
| ORMDL2 | RBM20 | 0.760418 | 3 | 0 | 3 |
| ORMDL2 | PLIN3 | 0.757174 | 9 | 0 | 9 |
| ORMDL2 | PRSS27 | 0.754863 | 4 | 0 | 4 |
| ORMDL2 | SH3GL1 | 0.75343 | 9 | 0 | 9 |
| ORMDL2 | ARPC2 | 0.752698 | 8 | 0 | 8 |
For details and further investigation, click here
