| Full name: TP53RK binding protein | Alias Symbol: CGI-121|CGI121 | ||
| Type: protein-coding gene | Cytoband: 2p13.1 | ||
| Entrez ID: 51002 | HGNC ID: HGNC:24259 | Ensembl Gene: ENSG00000144034 | OMIM ID: 608680 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TPRKB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPRKB | 51002 | 219030_at | -0.1815 | 0.6675 | |
| GSE20347 | TPRKB | 51002 | 219030_at | 0.0625 | 0.7520 | |
| GSE23400 | TPRKB | 51002 | 219030_at | 0.4188 | 0.0000 | |
| GSE26886 | TPRKB | 51002 | 219030_at | 0.2677 | 0.1646 | |
| GSE29001 | TPRKB | 51002 | 219030_at | 0.1036 | 0.8099 | |
| GSE38129 | TPRKB | 51002 | 219030_at | 0.3118 | 0.0455 | |
| GSE45670 | TPRKB | 51002 | 219030_at | -0.0090 | 0.9583 | |
| GSE53622 | TPRKB | 51002 | 81140 | -0.0216 | 0.7419 | |
| GSE53624 | TPRKB | 51002 | 81140 | 0.0897 | 0.3603 | |
| GSE63941 | TPRKB | 51002 | 219030_at | 1.4256 | 0.0001 | |
| GSE77861 | TPRKB | 51002 | 219030_at | -0.1432 | 0.6636 | |
| GSE97050 | TPRKB | 51002 | A_23_P5757 | 0.1159 | 0.6773 | |
| SRP007169 | TPRKB | 51002 | RNAseq | -0.3689 | 0.3662 | |
| SRP008496 | TPRKB | 51002 | RNAseq | -0.1520 | 0.6274 | |
| SRP064894 | TPRKB | 51002 | RNAseq | -0.0718 | 0.7021 | |
| SRP133303 | TPRKB | 51002 | RNAseq | 0.3439 | 0.0742 | |
| SRP159526 | TPRKB | 51002 | RNAseq | 0.0929 | 0.6691 | |
| SRP193095 | TPRKB | 51002 | RNAseq | -0.3720 | 0.0343 | |
| SRP219564 | TPRKB | 51002 | RNAseq | -0.2613 | 0.3797 | |
| TCGA | TPRKB | 51002 | RNAseq | 0.2408 | 0.0002 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TPRKB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TPRKB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPRKB | 51002 | 10 | 1 | 19 | |
| GSE20123 | TPRKB | 51002 | 10 | 1 | 19 | |
| GSE43470 | TPRKB | 51002 | 4 | 0 | 39 | |
| GSE46452 | TPRKB | 51002 | 2 | 3 | 54 | |
| GSE47630 | TPRKB | 51002 | 7 | 0 | 33 | |
| GSE54993 | TPRKB | 51002 | 0 | 6 | 64 | |
| GSE54994 | TPRKB | 51002 | 11 | 0 | 42 | |
| GSE60625 | TPRKB | 51002 | 0 | 3 | 8 | |
| GSE74703 | TPRKB | 51002 | 4 | 0 | 32 | |
| GSE74704 | TPRKB | 51002 | 8 | 0 | 12 | |
| TCGA | TPRKB | 51002 | 38 | 2 | 56 |
Total number of gains: 94; Total number of losses: 16; Total Number of normals: 378.
Somatic mutations of TPRKB:
Generating mutation plots.
Highly correlated genes for TPRKB:
Showing top 20/758 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPRKB | COX15 | 0.777743 | 3 | 0 | 3 |
| TPRKB | RAB18 | 0.756788 | 3 | 0 | 3 |
| TPRKB | ELOVL7 | 0.753269 | 3 | 0 | 3 |
| TPRKB | TMEM54 | 0.718766 | 3 | 0 | 3 |
| TPRKB | GDE1 | 0.717905 | 4 | 0 | 3 |
| TPRKB | VPS29 | 0.716348 | 4 | 0 | 4 |
| TPRKB | UBE2J1 | 0.715945 | 3 | 0 | 3 |
| TPRKB | TMEM167A | 0.710094 | 3 | 0 | 3 |
| TPRKB | TPD52 | 0.701781 | 4 | 0 | 3 |
| TPRKB | GJB3 | 0.701136 | 3 | 0 | 3 |
| TPRKB | ACY1 | 0.700656 | 3 | 0 | 3 |
| TPRKB | HOMER2 | 0.700509 | 3 | 0 | 3 |
| TPRKB | MRPL47 | 0.699605 | 3 | 0 | 3 |
| TPRKB | PUS7L | 0.696346 | 4 | 0 | 3 |
| TPRKB | TYSND1 | 0.694293 | 4 | 0 | 4 |
| TPRKB | DCTN6 | 0.688887 | 3 | 0 | 3 |
| TPRKB | PNO1 | 0.686086 | 4 | 0 | 4 |
| TPRKB | CUL5 | 0.684878 | 3 | 0 | 3 |
| TPRKB | COX6B1 | 0.683888 | 3 | 0 | 3 |
| TPRKB | RPL26L1 | 0.683867 | 8 | 0 | 8 |
For details and further investigation, click here
