| Full name: phospholipase D2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 5338 | HGNC ID: HGNC:9068 | Ensembl Gene: ENSG00000129219 | OMIM ID: 602384 |
| Drug and gene relationship at DGIdb | |||
PLD2 involved pathways:
Expression of PLD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLD2 | 5338 | 209643_s_at | -0.1282 | 0.8433 | |
| GSE20347 | PLD2 | 5338 | 209643_s_at | -0.4820 | 0.0000 | |
| GSE23400 | PLD2 | 5338 | 209643_s_at | -0.4177 | 0.0000 | |
| GSE26886 | PLD2 | 5338 | 209643_s_at | -0.5015 | 0.0014 | |
| GSE29001 | PLD2 | 5338 | 209643_s_at | -0.6730 | 0.0008 | |
| GSE38129 | PLD2 | 5338 | 209643_s_at | -0.4009 | 0.0081 | |
| GSE45670 | PLD2 | 5338 | 209643_s_at | 0.1553 | 0.2853 | |
| GSE53622 | PLD2 | 5338 | 19480 | -0.9043 | 0.0000 | |
| GSE53624 | PLD2 | 5338 | 19480 | -1.0197 | 0.0000 | |
| GSE63941 | PLD2 | 5338 | 209643_s_at | 0.5153 | 0.0429 | |
| GSE77861 | PLD2 | 5338 | 209643_s_at | -0.1474 | 0.3986 | |
| GSE97050 | PLD2 | 5338 | A_33_P3286724 | 0.0172 | 0.9671 | |
| SRP007169 | PLD2 | 5338 | RNAseq | -2.4420 | 0.0000 | |
| SRP008496 | PLD2 | 5338 | RNAseq | -2.3859 | 0.0000 | |
| SRP064894 | PLD2 | 5338 | RNAseq | -0.8840 | 0.0000 | |
| SRP133303 | PLD2 | 5338 | RNAseq | -0.9650 | 0.0000 | |
| SRP159526 | PLD2 | 5338 | RNAseq | -1.2653 | 0.0000 | |
| SRP193095 | PLD2 | 5338 | RNAseq | -0.7312 | 0.0004 | |
| SRP219564 | PLD2 | 5338 | RNAseq | -1.0354 | 0.0937 | |
| TCGA | PLD2 | 5338 | RNAseq | 0.1766 | 0.0242 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by PLD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLD2 | 5338 | 5 | 2 | 23 | |
| GSE20123 | PLD2 | 5338 | 5 | 3 | 22 | |
| GSE43470 | PLD2 | 5338 | 1 | 6 | 36 | |
| GSE46452 | PLD2 | 5338 | 34 | 1 | 24 | |
| GSE47630 | PLD2 | 5338 | 7 | 1 | 32 | |
| GSE54993 | PLD2 | 5338 | 4 | 3 | 63 | |
| GSE54994 | PLD2 | 5338 | 5 | 9 | 39 | |
| GSE60625 | PLD2 | 5338 | 4 | 0 | 7 | |
| GSE74703 | PLD2 | 5338 | 1 | 3 | 32 | |
| GSE74704 | PLD2 | 5338 | 3 | 1 | 16 | |
| TCGA | PLD2 | 5338 | 19 | 21 | 56 |
Total number of gains: 88; Total number of losses: 50; Total Number of normals: 350.
Somatic mutations of PLD2:
Generating mutation plots.
Highly correlated genes for PLD2:
Showing top 20/1386 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLD2 | DDI2 | 0.787172 | 3 | 0 | 3 |
| PLD2 | TMEM167A | 0.777976 | 3 | 0 | 3 |
| PLD2 | EPGN | 0.759724 | 3 | 0 | 3 |
| PLD2 | ELOVL1 | 0.749427 | 3 | 0 | 3 |
| PLD2 | GIPC1 | 0.739903 | 11 | 0 | 11 |
| PLD2 | ARHGAP27 | 0.737104 | 6 | 0 | 6 |
| PLD2 | ALS2CL | 0.725237 | 12 | 0 | 12 |
| PLD2 | TMEM161B | 0.723649 | 3 | 0 | 3 |
| PLD2 | HCG27 | 0.717769 | 3 | 0 | 3 |
| PLD2 | TOM1 | 0.717762 | 12 | 0 | 11 |
| PLD2 | NUAK2 | 0.714494 | 4 | 0 | 3 |
| PLD2 | LTA4H | 0.711752 | 3 | 0 | 3 |
| PLD2 | VPS25 | 0.710309 | 4 | 0 | 3 |
| PLD2 | TGM1 | 0.709433 | 12 | 0 | 11 |
| PLD2 | IMP3 | 0.707638 | 3 | 0 | 3 |
| PLD2 | MRPL30 | 0.70722 | 3 | 0 | 3 |
| PLD2 | SFMBT1 | 0.706131 | 3 | 0 | 3 |
| PLD2 | SH3GL1 | 0.705259 | 11 | 0 | 10 |
| PLD2 | TMCO6 | 0.70164 | 4 | 0 | 4 |
| PLD2 | DGKA | 0.700585 | 12 | 0 | 11 |
For details and further investigation, click here
