| Full name: SH3 domain containing GRB2 like 1, endophilin A2 | Alias Symbol: SH3P8|SH3D2B|CNSA1|EEN|MGC111371 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 6455 | HGNC ID: HGNC:10830 | Ensembl Gene: ENSG00000141985 | OMIM ID: 601768 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SH3GL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH3GL1 | 6455 | 201851_at | -0.6917 | 0.1409 | |
| GSE20347 | SH3GL1 | 6455 | 201851_at | -1.1039 | 0.0000 | |
| GSE23400 | SH3GL1 | 6455 | 201851_at | -0.9779 | 0.0000 | |
| GSE26886 | SH3GL1 | 6455 | 201851_at | -1.2028 | 0.0000 | |
| GSE29001 | SH3GL1 | 6455 | 201851_at | -1.3296 | 0.0001 | |
| GSE38129 | SH3GL1 | 6455 | 201851_at | -0.7881 | 0.0000 | |
| GSE45670 | SH3GL1 | 6455 | 201851_at | -0.4789 | 0.0089 | |
| GSE53622 | SH3GL1 | 6455 | 73078 | -0.9985 | 0.0000 | |
| GSE53624 | SH3GL1 | 6455 | 73078 | -1.0403 | 0.0000 | |
| GSE63941 | SH3GL1 | 6455 | 201851_at | 0.1016 | 0.7461 | |
| GSE77861 | SH3GL1 | 6455 | 201851_at | -0.7768 | 0.0020 | |
| GSE97050 | SH3GL1 | 6455 | A_24_P139094 | -0.0131 | 0.9820 | |
| SRP007169 | SH3GL1 | 6455 | RNAseq | -2.4019 | 0.0000 | |
| SRP008496 | SH3GL1 | 6455 | RNAseq | -2.2579 | 0.0000 | |
| SRP064894 | SH3GL1 | 6455 | RNAseq | -1.4817 | 0.0000 | |
| SRP133303 | SH3GL1 | 6455 | RNAseq | -1.2564 | 0.0000 | |
| SRP159526 | SH3GL1 | 6455 | RNAseq | -1.5322 | 0.0000 | |
| SRP193095 | SH3GL1 | 6455 | RNAseq | -1.2884 | 0.0000 | |
| SRP219564 | SH3GL1 | 6455 | RNAseq | -1.1363 | 0.0094 | |
| TCGA | SH3GL1 | 6455 | RNAseq | 0.1595 | 0.0033 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by SH3GL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH3GL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH3GL1 | 6455 | 5 | 3 | 22 | |
| GSE20123 | SH3GL1 | 6455 | 4 | 2 | 24 | |
| GSE43470 | SH3GL1 | 6455 | 1 | 8 | 34 | |
| GSE46452 | SH3GL1 | 6455 | 47 | 1 | 11 | |
| GSE47630 | SH3GL1 | 6455 | 5 | 7 | 28 | |
| GSE54993 | SH3GL1 | 6455 | 16 | 3 | 51 | |
| GSE54994 | SH3GL1 | 6455 | 6 | 16 | 31 | |
| GSE60625 | SH3GL1 | 6455 | 9 | 0 | 2 | |
| GSE74703 | SH3GL1 | 6455 | 1 | 5 | 30 | |
| GSE74704 | SH3GL1 | 6455 | 1 | 2 | 17 | |
| TCGA | SH3GL1 | 6455 | 10 | 19 | 67 |
Total number of gains: 105; Total number of losses: 66; Total Number of normals: 317.
Somatic mutations of SH3GL1:
Generating mutation plots.
Highly correlated genes for SH3GL1:
Showing top 20/1912 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH3GL1 | MXD1 | 0.874264 | 10 | 0 | 10 |
| SH3GL1 | ARHGAP27 | 0.863987 | 7 | 0 | 7 |
| SH3GL1 | GDPD3 | 0.863824 | 10 | 0 | 10 |
| SH3GL1 | TRIP10 | 0.862843 | 11 | 0 | 10 |
| SH3GL1 | ECM1 | 0.861079 | 10 | 0 | 10 |
| SH3GL1 | GYS2 | 0.860033 | 10 | 0 | 10 |
| SH3GL1 | EHD3 | 0.852395 | 11 | 0 | 11 |
| SH3GL1 | ESPL1 | 0.850458 | 10 | 0 | 10 |
| SH3GL1 | PRSS27 | 0.844034 | 6 | 0 | 6 |
| SH3GL1 | SLURP1 | 0.843584 | 10 | 0 | 10 |
| SH3GL1 | TP53I3 | 0.843325 | 11 | 0 | 11 |
| SH3GL1 | TOM1 | 0.841172 | 12 | 0 | 11 |
| SH3GL1 | SFTA2 | 0.839413 | 4 | 0 | 4 |
| SH3GL1 | ALS2CL | 0.839037 | 10 | 0 | 10 |
| SH3GL1 | SULT2B1 | 0.838725 | 8 | 0 | 8 |
| SH3GL1 | TECR | 0.837447 | 10 | 0 | 10 |
| SH3GL1 | EPS8L1 | 0.829706 | 11 | 0 | 10 |
| SH3GL1 | VSIG10L | 0.828726 | 6 | 0 | 6 |
| SH3GL1 | TMOD3 | 0.828508 | 11 | 0 | 11 |
| SH3GL1 | PADI1 | 0.827961 | 8 | 0 | 8 |
For details and further investigation, click here
