| Full name: catechol-O-methyltransferase domain containing 1 | Alias Symbol: FLJ23841 | ||
| Type: protein-coding gene | Cytoband: 10q22.2 | ||
| Entrez ID: 118881 | HGNC ID: HGNC:26309 | Ensembl Gene: ENSG00000165644 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of COMTD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COMTD1 | 118881 | 226870_at | -0.4437 | 0.1889 | |
| GSE26886 | COMTD1 | 118881 | 226870_at | 0.0187 | 0.9505 | |
| GSE45670 | COMTD1 | 118881 | 226870_at | -0.1461 | 0.4669 | |
| GSE53622 | COMTD1 | 118881 | 131524 | -1.1168 | 0.0000 | |
| GSE53624 | COMTD1 | 118881 | 131524 | -1.0066 | 0.0000 | |
| GSE63941 | COMTD1 | 118881 | 226870_at | 0.6732 | 0.1122 | |
| GSE77861 | COMTD1 | 118881 | 226870_at | -0.6996 | 0.0150 | |
| GSE97050 | COMTD1 | 118881 | A_33_P3257222 | 0.0674 | 0.8793 | |
| SRP007169 | COMTD1 | 118881 | RNAseq | -2.3884 | 0.0000 | |
| SRP008496 | COMTD1 | 118881 | RNAseq | -1.7660 | 0.0000 | |
| SRP064894 | COMTD1 | 118881 | RNAseq | -0.7770 | 0.0349 | |
| SRP133303 | COMTD1 | 118881 | RNAseq | -0.9943 | 0.0000 | |
| SRP159526 | COMTD1 | 118881 | RNAseq | -1.4073 | 0.0022 | |
| SRP193095 | COMTD1 | 118881 | RNAseq | -1.0718 | 0.0000 | |
| SRP219564 | COMTD1 | 118881 | RNAseq | -0.1033 | 0.8946 | |
| TCGA | COMTD1 | 118881 | RNAseq | 0.0293 | 0.7713 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by COMTD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COMTD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COMTD1 | 118881 | 3 | 5 | 22 | |
| GSE20123 | COMTD1 | 118881 | 3 | 4 | 23 | |
| GSE43470 | COMTD1 | 118881 | 2 | 7 | 34 | |
| GSE46452 | COMTD1 | 118881 | 0 | 11 | 48 | |
| GSE47630 | COMTD1 | 118881 | 2 | 14 | 24 | |
| GSE54993 | COMTD1 | 118881 | 7 | 0 | 63 | |
| GSE54994 | COMTD1 | 118881 | 2 | 10 | 41 | |
| GSE60625 | COMTD1 | 118881 | 0 | 0 | 11 | |
| GSE74703 | COMTD1 | 118881 | 2 | 4 | 30 | |
| GSE74704 | COMTD1 | 118881 | 1 | 2 | 17 | |
| TCGA | COMTD1 | 118881 | 11 | 23 | 62 |
Total number of gains: 33; Total number of losses: 80; Total Number of normals: 375.
Somatic mutations of COMTD1:
Generating mutation plots.
Highly correlated genes for COMTD1:
Showing top 20/1055 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COMTD1 | DDI2 | 0.79567 | 3 | 0 | 3 |
| COMTD1 | CHCHD1 | 0.779711 | 4 | 0 | 4 |
| COMTD1 | POLR2L | 0.765841 | 3 | 0 | 3 |
| COMTD1 | BARX2 | 0.759626 | 6 | 0 | 5 |
| COMTD1 | LTA4H | 0.754599 | 3 | 0 | 3 |
| COMTD1 | NUAK2 | 0.752919 | 3 | 0 | 3 |
| COMTD1 | RETSAT | 0.749515 | 3 | 0 | 3 |
| COMTD1 | TMEM234 | 0.744932 | 3 | 0 | 3 |
| COMTD1 | PPA1 | 0.744491 | 3 | 0 | 3 |
| COMTD1 | SYTL1 | 0.743043 | 7 | 0 | 7 |
| COMTD1 | MAU2 | 0.742045 | 4 | 0 | 4 |
| COMTD1 | TAX1BP3 | 0.740253 | 3 | 0 | 3 |
| COMTD1 | COX6B1 | 0.739348 | 4 | 0 | 4 |
| COMTD1 | ELOVL1 | 0.738064 | 3 | 0 | 3 |
| COMTD1 | MAP2K3 | 0.735086 | 3 | 0 | 3 |
| COMTD1 | RGS14 | 0.729924 | 7 | 0 | 6 |
| COMTD1 | TSPO | 0.726731 | 6 | 0 | 5 |
| COMTD1 | UBL5 | 0.725628 | 3 | 0 | 3 |
| COMTD1 | ATP6AP1 | 0.724698 | 4 | 0 | 3 |
| COMTD1 | RAB25 | 0.723244 | 7 | 0 | 6 |
For details and further investigation, click here
