| Full name: 4-hydroxyphenylpyruvate dioxygenase | Alias Symbol: 4-HPPD|4HPPD|GLOD3 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 3242 | HGNC ID: HGNC:5147 | Ensembl Gene: ENSG00000158104 | OMIM ID: 609695 |
| Drug and gene relationship at DGIdb | |||
Expression of HPD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HPD | 3242 | 206024_at | 0.0561 | 0.8804 | |
| GSE20347 | HPD | 3242 | 206024_at | 0.0303 | 0.6391 | |
| GSE23400 | HPD | 3242 | 206024_at | -0.0409 | 0.5209 | |
| GSE26886 | HPD | 3242 | 206024_at | 0.1579 | 0.1064 | |
| GSE29001 | HPD | 3242 | 206024_at | -0.1841 | 0.0595 | |
| GSE38129 | HPD | 3242 | 206024_at | -0.1028 | 0.1206 | |
| GSE45670 | HPD | 3242 | 206024_at | -0.0139 | 0.8776 | |
| GSE53622 | HPD | 3242 | 7711 | -0.5680 | 0.0000 | |
| GSE53624 | HPD | 3242 | 7711 | -0.5031 | 0.0000 | |
| GSE63941 | HPD | 3242 | 206024_at | 0.2763 | 0.1836 | |
| GSE77861 | HPD | 3242 | 206024_at | -0.0303 | 0.8209 | |
| GSE97050 | HPD | 3242 | A_23_P139527 | 0.1044 | 0.5790 | |
| SRP159526 | HPD | 3242 | RNAseq | -0.4339 | 0.5234 | |
| TCGA | HPD | 3242 | RNAseq | -1.4640 | 0.0238 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HPD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HPD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HPD | 3242 | 5 | 4 | 21 | |
| GSE20123 | HPD | 3242 | 5 | 4 | 21 | |
| GSE43470 | HPD | 3242 | 2 | 2 | 39 | |
| GSE46452 | HPD | 3242 | 9 | 1 | 49 | |
| GSE47630 | HPD | 3242 | 9 | 3 | 28 | |
| GSE54993 | HPD | 3242 | 0 | 5 | 65 | |
| GSE54994 | HPD | 3242 | 6 | 7 | 40 | |
| GSE60625 | HPD | 3242 | 0 | 0 | 11 | |
| GSE74703 | HPD | 3242 | 2 | 1 | 33 | |
| GSE74704 | HPD | 3242 | 4 | 2 | 14 | |
| TCGA | HPD | 3242 | 21 | 10 | 65 |
Total number of gains: 63; Total number of losses: 39; Total Number of normals: 386.
Somatic mutations of HPD:
Generating mutation plots.
Highly correlated genes for HPD:
Showing top 20/76 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HPD | BTNL9 | 0.726899 | 3 | 0 | 3 |
| HPD | LYPD4 | 0.708971 | 3 | 0 | 3 |
| HPD | PSPN | 0.695085 | 3 | 0 | 3 |
| HPD | DOK7 | 0.689489 | 3 | 0 | 3 |
| HPD | FSIP1 | 0.663351 | 4 | 0 | 3 |
| HPD | DPEP3 | 0.64003 | 4 | 0 | 3 |
| HPD | TEKT2 | 0.632929 | 4 | 0 | 3 |
| HPD | PTGDR2 | 0.630643 | 5 | 0 | 4 |
| HPD | KLHL34 | 0.629136 | 4 | 0 | 3 |
| HPD | DNAI1 | 0.618655 | 4 | 0 | 3 |
| HPD | GPR17 | 0.618377 | 6 | 0 | 5 |
| HPD | GAB2 | 0.616916 | 4 | 0 | 3 |
| HPD | CELA3B | 0.61689 | 5 | 0 | 3 |
| HPD | CLDN14 | 0.616694 | 5 | 0 | 3 |
| HPD | DHH | 0.614019 | 4 | 0 | 3 |
| HPD | FOXB1 | 0.612505 | 5 | 0 | 4 |
| HPD | FAM186B | 0.611348 | 4 | 0 | 4 |
| HPD | IFIT2 | 0.600645 | 3 | 0 | 3 |
| HPD | ATOH8 | 0.600068 | 4 | 0 | 3 |
| HPD | MYL4 | 0.598082 | 5 | 0 | 3 |
For details and further investigation, click here
