| Full name: interferon induced protein with tetratricopeptide repeats 2 | Alias Symbol: IFI-54|ISG-54K|cig42|GARG-39 | ||
| Type: protein-coding gene | Cytoband: 10q23.31 | ||
| Entrez ID: 3433 | HGNC ID: HGNC:5409 | Ensembl Gene: ENSG00000119922 | OMIM ID: 147040 |
| Drug and gene relationship at DGIdb | |||
Expression of IFIT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IFIT2 | 3433 | 226757_at | 0.6179 | 0.4991 | |
| GSE20347 | IFIT2 | 3433 | 217502_at | 0.1035 | 0.4971 | |
| GSE23400 | IFIT2 | 3433 | 217502_at | 0.0161 | 0.7926 | |
| GSE26886 | IFIT2 | 3433 | 226757_at | 0.1718 | 0.7990 | |
| GSE29001 | IFIT2 | 3433 | 217502_at | 0.6268 | 0.0685 | |
| GSE38129 | IFIT2 | 3433 | 217502_at | 0.0361 | 0.8241 | |
| GSE45670 | IFIT2 | 3433 | 226757_at | 1.3230 | 0.0089 | |
| GSE53622 | IFIT2 | 3433 | 56049 | -0.4681 | 0.0013 | |
| GSE53624 | IFIT2 | 3433 | 56049 | -0.2950 | 0.0093 | |
| GSE63941 | IFIT2 | 3433 | 226757_at | -1.3427 | 0.4717 | |
| GSE77861 | IFIT2 | 3433 | 217502_at | 0.0303 | 0.9104 | |
| GSE97050 | IFIT2 | 3433 | A_23_P24004 | -0.3974 | 0.3758 | |
| SRP007169 | IFIT2 | 3433 | RNAseq | 2.5584 | 0.0001 | |
| SRP008496 | IFIT2 | 3433 | RNAseq | 2.7567 | 0.0000 | |
| SRP064894 | IFIT2 | 3433 | RNAseq | 2.6244 | 0.0000 | |
| SRP133303 | IFIT2 | 3433 | RNAseq | 1.0678 | 0.0009 | |
| SRP159526 | IFIT2 | 3433 | RNAseq | 0.6451 | 0.3799 | |
| SRP193095 | IFIT2 | 3433 | RNAseq | 1.6764 | 0.0000 | |
| SRP219564 | IFIT2 | 3433 | RNAseq | 1.8395 | 0.0298 | |
| TCGA | IFIT2 | 3433 | RNAseq | 0.6951 | 0.0001 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by IFIT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IFIT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IFIT2 | 3433 | 2 | 7 | 21 | |
| GSE20123 | IFIT2 | 3433 | 2 | 6 | 22 | |
| GSE43470 | IFIT2 | 3433 | 0 | 8 | 35 | |
| GSE46452 | IFIT2 | 3433 | 0 | 11 | 48 | |
| GSE47630 | IFIT2 | 3433 | 2 | 14 | 24 | |
| GSE54993 | IFIT2 | 3433 | 7 | 0 | 63 | |
| GSE54994 | IFIT2 | 3433 | 1 | 11 | 41 | |
| GSE60625 | IFIT2 | 3433 | 0 | 0 | 11 | |
| GSE74703 | IFIT2 | 3433 | 0 | 6 | 30 | |
| GSE74704 | IFIT2 | 3433 | 1 | 4 | 15 | |
| TCGA | IFIT2 | 3433 | 8 | 27 | 61 |
Total number of gains: 23; Total number of losses: 94; Total Number of normals: 371.
Somatic mutations of IFIT2:
Generating mutation plots.
Highly correlated genes for IFIT2:
Showing top 20/65 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IFIT2 | IFIT3 | 0.692761 | 12 | 0 | 10 |
| IFIT2 | BTN3A3 | 0.649284 | 5 | 0 | 4 |
| IFIT2 | PSMB8-AS1 | 0.632388 | 3 | 0 | 3 |
| IFIT2 | UBE2L6 | 0.627722 | 7 | 0 | 5 |
| IFIT2 | HLA-G | 0.62594 | 4 | 0 | 3 |
| IFIT2 | LAMP3 | 0.625605 | 5 | 0 | 4 |
| IFIT2 | OAS2 | 0.622843 | 10 | 0 | 7 |
| IFIT2 | IFI44 | 0.621693 | 10 | 0 | 7 |
| IFIT2 | IFITM1 | 0.621458 | 6 | 0 | 5 |
| IFIT2 | ZNFX1 | 0.620994 | 6 | 0 | 5 |
| IFIT2 | HLA-C | 0.620627 | 5 | 0 | 3 |
| IFIT2 | MX2 | 0.617928 | 11 | 0 | 6 |
| IFIT2 | HLA-B | 0.615461 | 5 | 0 | 4 |
| IFIT2 | CXCL11 | 0.615006 | 7 | 0 | 6 |
| IFIT2 | IGFLR1 | 0.610837 | 4 | 0 | 3 |
| IFIT2 | IFI35 | 0.609342 | 8 | 0 | 5 |
| IFIT2 | PSMB9 | 0.608026 | 8 | 0 | 6 |
| IFIT2 | IFI6 | 0.603089 | 8 | 0 | 6 |
| IFIT2 | HPD | 0.600645 | 3 | 0 | 3 |
| IFIT2 | OASL | 0.590379 | 11 | 0 | 7 |
For details and further investigation, click here
