GAB2

 

Full name: GRB2 associated binding protein 2 Alias Symbol: KIAA0571
Type: protein-coding gene Cytoband: 11q14.1
Entrez ID: 9846 HGNC ID: HGNC:14458 Ensembl Gene: ENSG00000033327 OMIM ID: 606203
Drug and gene relationship at DGIdb

 

GAB2 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04380Osteoclast differentiation
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa05220Chronic myeloid leukemia

 

Expression of GAB2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GAB2 9846 203853_s_at -0.9858 0.0112
GSE20347 GAB2 9846 203853_s_at -0.9801 0.0000
GSE23400 GAB2 9846 203853_s_at -0.6575 0.0000
GSE26886 GAB2 9846 203853_s_at -1.6964 0.0000
GSE29001 GAB2 9846 203853_s_at -1.2050 0.0001
GSE38129 GAB2 9846 203853_s_at -1.0501 0.0000
GSE45670 GAB2 9846 203853_s_at -1.2091 0.0000
GSE53622 GAB2 9846 15306 -1.1358 0.0000
GSE53624 GAB2 9846 15306 -1.1790 0.0000
GSE63941 GAB2 9846 203853_s_at -1.6815 0.0035
GSE77861 GAB2 9846 203853_s_at -0.4935 0.0064
GSE97050 GAB2 9846 A_23_P203743 -0.4414 0.2358
SRP007169 GAB2 9846 RNAseq -1.5040 0.0048
SRP064894 GAB2 9846 RNAseq -1.0284 0.0002
SRP133303 GAB2 9846 RNAseq -1.3076 0.0000
SRP159526 GAB2 9846 RNAseq -1.7491 0.0001
SRP193095 GAB2 9846 RNAseq -1.0623 0.0000
SRP219564 GAB2 9846 RNAseq -0.8989 0.0241
TCGA GAB2 9846 RNAseq -0.6016 0.0000

Upregulated datasets: 0; Downregulated datasets: 12.  

 

Survival by GAB2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GAB2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GAB2 9846 3 10 17
GSE20123 GAB2 9846 3 9 18
GSE43470 GAB2 9846 3 5 35
GSE46452 GAB2 9846 7 22 30
GSE47630 GAB2 9846 4 17 19
GSE54993 GAB2 9846 8 2 60
GSE54994 GAB2 9846 5 17 31
GSE60625 GAB2 9846 4 3 4
GSE74703 GAB2 9846 2 4 30
GSE74704 GAB2 9846 3 5 12
TCGA GAB2 9846 19 32 45

Total number of gains: 61; Total number of losses: 126; Total Number of normals: 301.  

 

Somatic mutations of GAB2:

 

Generating mutation plots.

 

Highly correlated genes for GAB2:

 

Showing top 20/846 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GAB2SFTA20.85763404
GAB2SH3BGRL20.851552606
GAB2SMIM50.835023606
GAB2SNORA680.834498404
GAB2FAM3D0.827715606
GAB2KRT780.826144606
GAB2HCG220.821123606
GAB2ABLIM30.8104812011
GAB2UBL30.80852410010
GAB2GDPD30.80588810010
GAB2GPR1460.805494303
GAB2GYS20.80164710010
GAB2CRISP30.79857910010
GAB2ENDOU0.79678110010
GAB2ANKRD350.796575707
GAB2MAPK30.79445310010
GAB2SCNN1B0.79288310010
GAB2FAM163B0.792703303
GAB2CYSRT10.787488606
GAB2SMDT10.782738404

For details and further investigation, click here