| Full name: heparan sulfate 2-O-sulfotransferase 1 | Alias Symbol: KIAA0448 | ||
| Type: protein-coding gene | Cytoband: 1p22.3 | ||
| Entrez ID: 9653 | HGNC ID: HGNC:5193 | Ensembl Gene: ENSG00000153936 | OMIM ID: 604844 |
| Drug and gene relationship at DGIdb | |||
Expression of HS2ST1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HS2ST1 | 9653 | 203284_s_at | 0.4685 | 0.4574 | |
| GSE20347 | HS2ST1 | 9653 | 203284_s_at | -0.0144 | 0.9615 | |
| GSE23400 | HS2ST1 | 9653 | 203284_s_at | 0.5687 | 0.0000 | |
| GSE26886 | HS2ST1 | 9653 | 203284_s_at | 0.7152 | 0.0142 | |
| GSE29001 | HS2ST1 | 9653 | 203284_s_at | 0.3475 | 0.3747 | |
| GSE38129 | HS2ST1 | 9653 | 203284_s_at | 0.4074 | 0.0390 | |
| GSE45670 | HS2ST1 | 9653 | 203284_s_at | 0.1244 | 0.4956 | |
| GSE53622 | HS2ST1 | 9653 | 27907 | 0.0595 | 0.5994 | |
| GSE53624 | HS2ST1 | 9653 | 27907 | 0.1814 | 0.0851 | |
| GSE63941 | HS2ST1 | 9653 | 203284_s_at | -0.1162 | 0.8647 | |
| GSE77861 | HS2ST1 | 9653 | 203284_s_at | -0.0633 | 0.8375 | |
| GSE97050 | HS2ST1 | 9653 | A_33_P3226630 | 0.0951 | 0.6732 | |
| SRP007169 | HS2ST1 | 9653 | RNAseq | 0.2103 | 0.5565 | |
| SRP008496 | HS2ST1 | 9653 | RNAseq | 0.1672 | 0.3938 | |
| SRP064894 | HS2ST1 | 9653 | RNAseq | 0.7688 | 0.0000 | |
| SRP133303 | HS2ST1 | 9653 | RNAseq | 0.4089 | 0.0056 | |
| SRP159526 | HS2ST1 | 9653 | RNAseq | 0.1213 | 0.6051 | |
| SRP193095 | HS2ST1 | 9653 | RNAseq | 0.0758 | 0.4901 | |
| SRP219564 | HS2ST1 | 9653 | RNAseq | 0.2997 | 0.3600 | |
| TCGA | HS2ST1 | 9653 | RNAseq | -0.0203 | 0.6830 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HS2ST1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HS2ST1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HS2ST1 | 9653 | 0 | 8 | 22 | |
| GSE20123 | HS2ST1 | 9653 | 0 | 8 | 22 | |
| GSE43470 | HS2ST1 | 9653 | 2 | 2 | 39 | |
| GSE46452 | HS2ST1 | 9653 | 1 | 1 | 57 | |
| GSE47630 | HS2ST1 | 9653 | 8 | 5 | 27 | |
| GSE54993 | HS2ST1 | 9653 | 0 | 1 | 69 | |
| GSE54994 | HS2ST1 | 9653 | 6 | 3 | 44 | |
| GSE60625 | HS2ST1 | 9653 | 0 | 0 | 11 | |
| GSE74703 | HS2ST1 | 9653 | 1 | 2 | 33 | |
| GSE74704 | HS2ST1 | 9653 | 0 | 5 | 15 | |
| TCGA | HS2ST1 | 9653 | 6 | 23 | 67 |
Total number of gains: 24; Total number of losses: 58; Total Number of normals: 406.
Somatic mutations of HS2ST1:
Generating mutation plots.
Highly correlated genes for HS2ST1:
Showing top 20/70 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HS2ST1 | MID1 | 0.709985 | 3 | 0 | 3 |
| HS2ST1 | CD300LF | 0.704708 | 3 | 0 | 3 |
| HS2ST1 | RFESD | 0.684384 | 4 | 0 | 3 |
| HS2ST1 | GPN2 | 0.651207 | 5 | 0 | 4 |
| HS2ST1 | TREM1 | 0.651018 | 3 | 0 | 3 |
| HS2ST1 | PTPRR | 0.650769 | 3 | 0 | 3 |
| HS2ST1 | RWDD3 | 0.629846 | 8 | 0 | 6 |
| HS2ST1 | IGFL2 | 0.614359 | 4 | 0 | 3 |
| HS2ST1 | LAYN | 0.614152 | 4 | 0 | 4 |
| HS2ST1 | EPB41L4B | 0.610714 | 4 | 0 | 3 |
| HS2ST1 | POLR3A | 0.609869 | 3 | 0 | 3 |
| HS2ST1 | HSPBAP1 | 0.602527 | 5 | 0 | 4 |
| HS2ST1 | EOGT | 0.595263 | 3 | 0 | 3 |
| HS2ST1 | C1QTNF6 | 0.593763 | 4 | 0 | 3 |
| HS2ST1 | LCE1B | 0.58913 | 3 | 0 | 3 |
| HS2ST1 | ITGA4 | 0.583587 | 4 | 0 | 3 |
| HS2ST1 | GPR180 | 0.583029 | 5 | 0 | 3 |
| HS2ST1 | MYO10 | 0.582949 | 5 | 0 | 3 |
| HS2ST1 | CBX3 | 0.581418 | 7 | 0 | 6 |
| HS2ST1 | PAG1 | 0.575915 | 6 | 0 | 3 |
For details and further investigation, click here
