| Full name: chromobox 3 | Alias Symbol: HP1Hs-gamma | ||
| Type: protein-coding gene | Cytoband: 7p15.2 | ||
| Entrez ID: 11335 | HGNC ID: HGNC:1553 | Ensembl Gene: ENSG00000122565 | OMIM ID: 604477 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CBX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CBX3 | 11335 | 200037_s_at | 0.7601 | 0.0462 | |
| GSE20347 | CBX3 | 11335 | 200037_s_at | 1.2264 | 0.0000 | |
| GSE23400 | CBX3 | 11335 | 200037_s_at | 1.2291 | 0.0000 | |
| GSE26886 | CBX3 | 11335 | 200037_s_at | 0.8362 | 0.0003 | |
| GSE29001 | CBX3 | 11335 | 200037_s_at | 1.0538 | 0.0002 | |
| GSE38129 | CBX3 | 11335 | 200037_s_at | 1.2614 | 0.0000 | |
| GSE45670 | CBX3 | 11335 | 200037_s_at | 0.6242 | 0.0006 | |
| GSE53622 | CBX3 | 11335 | 83491 | 1.1090 | 0.0000 | |
| GSE53624 | CBX3 | 11335 | 83491 | 1.2575 | 0.0000 | |
| GSE63941 | CBX3 | 11335 | 200037_s_at | 0.3602 | 0.2560 | |
| GSE77861 | CBX3 | 11335 | 200037_s_at | 0.7924 | 0.0145 | |
| GSE97050 | CBX3 | 11335 | A_23_P31315 | 0.5838 | 0.1657 | |
| SRP007169 | CBX3 | 11335 | RNAseq | 1.3318 | 0.0001 | |
| SRP008496 | CBX3 | 11335 | RNAseq | 1.7085 | 0.0000 | |
| SRP064894 | CBX3 | 11335 | RNAseq | 1.0800 | 0.0000 | |
| SRP133303 | CBX3 | 11335 | RNAseq | 1.1948 | 0.0000 | |
| SRP159526 | CBX3 | 11335 | RNAseq | 0.8574 | 0.0003 | |
| SRP193095 | CBX3 | 11335 | RNAseq | 0.6435 | 0.0000 | |
| SRP219564 | CBX3 | 11335 | RNAseq | 0.7937 | 0.0315 | |
| TCGA | CBX3 | 11335 | RNAseq | 0.3449 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by CBX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CBX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CBX3 | 11335 | 16 | 1 | 13 | |
| GSE20123 | CBX3 | 11335 | 16 | 1 | 13 | |
| GSE43470 | CBX3 | 11335 | 4 | 0 | 39 | |
| GSE46452 | CBX3 | 11335 | 10 | 2 | 47 | |
| GSE47630 | CBX3 | 11335 | 9 | 1 | 30 | |
| GSE54993 | CBX3 | 11335 | 0 | 6 | 64 | |
| GSE54994 | CBX3 | 11335 | 21 | 2 | 30 | |
| GSE60625 | CBX3 | 11335 | 0 | 0 | 11 | |
| GSE74703 | CBX3 | 11335 | 4 | 0 | 32 | |
| GSE74704 | CBX3 | 11335 | 10 | 1 | 9 | |
| TCGA | CBX3 | 11335 | 55 | 6 | 35 |
Total number of gains: 145; Total number of losses: 20; Total Number of normals: 323.
Somatic mutations of CBX3:
Generating mutation plots.
Highly correlated genes for CBX3:
Showing top 20/1170 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CBX3 | ECT2 | 0.833697 | 11 | 0 | 11 |
| CBX3 | CKS1B | 0.825464 | 11 | 0 | 11 |
| CBX3 | RFC4 | 0.817672 | 11 | 0 | 11 |
| CBX3 | ACTL6A | 0.815329 | 10 | 0 | 10 |
| CBX3 | NCAPG2 | 0.805949 | 9 | 0 | 9 |
| CBX3 | GMNN | 0.801338 | 10 | 0 | 10 |
| CBX3 | FEN1 | 0.799674 | 9 | 0 | 9 |
| CBX3 | FANCI | 0.799024 | 10 | 0 | 10 |
| CBX3 | MCM2 | 0.796424 | 11 | 0 | 11 |
| CBX3 | KIF4A | 0.794272 | 11 | 0 | 10 |
| CBX3 | DLGAP5 | 0.791014 | 11 | 0 | 10 |
| CBX3 | WDHD1 | 0.788507 | 10 | 0 | 10 |
| CBX3 | CDCA5 | 0.787584 | 7 | 0 | 7 |
| CBX3 | SNRPE | 0.787435 | 10 | 0 | 10 |
| CBX3 | DTL | 0.787237 | 10 | 0 | 10 |
| CBX3 | PLAU | 0.78644 | 10 | 0 | 10 |
| CBX3 | GINS1 | 0.786197 | 10 | 0 | 10 |
| CBX3 | CDKN3 | 0.786114 | 10 | 0 | 9 |
| CBX3 | ANLN | 0.785268 | 6 | 0 | 6 |
| CBX3 | HJURP | 0.785005 | 9 | 0 | 9 |
For details and further investigation, click here
