| Full name: hydroxysteroid 17-beta dehydrogenase 11 | Alias Symbol: RetSDR2|17-BETA-HSD11|17-BETA-HSDXI|PAN1B|SDR16C2 | ||
| Type: protein-coding gene | Cytoband: 4q22.1 | ||
| Entrez ID: 51170 | HGNC ID: HGNC:22960 | Ensembl Gene: ENSG00000198189 | OMIM ID: 612831 |
Expression of HSD17B11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD17B11 | 51170 | 217989_at | -0.2169 | 0.7452 | |
| GSE20347 | HSD17B11 | 51170 | 217989_at | 0.8785 | 0.0029 | |
| GSE23400 | HSD17B11 | 51170 | 217989_at | 0.5340 | 0.0003 | |
| GSE26886 | HSD17B11 | 51170 | 217989_at | 1.5873 | 0.0042 | |
| GSE29001 | HSD17B11 | 51170 | 217989_at | 0.8956 | 0.0522 | |
| GSE38129 | HSD17B11 | 51170 | 217989_at | 0.3866 | 0.2151 | |
| GSE45670 | HSD17B11 | 51170 | 217989_at | -0.4677 | 0.1603 | |
| GSE53622 | HSD17B11 | 51170 | 132149 | 0.3045 | 0.0135 | |
| GSE53624 | HSD17B11 | 51170 | 132149 | 0.4585 | 0.0028 | |
| GSE63941 | HSD17B11 | 51170 | 217989_at | -1.4236 | 0.2948 | |
| GSE77861 | HSD17B11 | 51170 | 217989_at | 0.9822 | 0.1677 | |
| GSE97050 | HSD17B11 | 51170 | A_23_P408271 | 0.2489 | 0.2637 | |
| SRP007169 | HSD17B11 | 51170 | RNAseq | 1.3605 | 0.0001 | |
| SRP008496 | HSD17B11 | 51170 | RNAseq | 1.1114 | 0.0000 | |
| SRP064894 | HSD17B11 | 51170 | RNAseq | 0.3293 | 0.2184 | |
| SRP133303 | HSD17B11 | 51170 | RNAseq | 0.5125 | 0.0246 | |
| SRP159526 | HSD17B11 | 51170 | RNAseq | 0.4366 | 0.0775 | |
| SRP193095 | HSD17B11 | 51170 | RNAseq | 0.5039 | 0.0929 | |
| SRP219564 | HSD17B11 | 51170 | RNAseq | -0.2149 | 0.6785 | |
| TCGA | HSD17B11 | 51170 | RNAseq | -0.1851 | 0.0393 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by HSD17B11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD17B11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD17B11 | 51170 | 3 | 12 | 15 | |
| GSE20123 | HSD17B11 | 51170 | 3 | 12 | 15 | |
| GSE43470 | HSD17B11 | 51170 | 0 | 13 | 30 | |
| GSE46452 | HSD17B11 | 51170 | 2 | 35 | 22 | |
| GSE47630 | HSD17B11 | 51170 | 0 | 20 | 20 | |
| GSE54993 | HSD17B11 | 51170 | 8 | 0 | 62 | |
| GSE54994 | HSD17B11 | 51170 | 1 | 9 | 43 | |
| GSE60625 | HSD17B11 | 51170 | 0 | 0 | 11 | |
| GSE74703 | HSD17B11 | 51170 | 0 | 11 | 25 | |
| GSE74704 | HSD17B11 | 51170 | 2 | 7 | 11 | |
| TCGA | HSD17B11 | 51170 | 12 | 36 | 48 |
Total number of gains: 31; Total number of losses: 155; Total Number of normals: 302.
Somatic mutations of HSD17B11:
Generating mutation plots.
Highly correlated genes for HSD17B11:
Showing top 20/1250 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD17B11 | DHRSX | 0.83196 | 3 | 0 | 3 |
| HSD17B11 | SNX13 | 0.784105 | 3 | 0 | 3 |
| HSD17B11 | COMMD7 | 0.768364 | 3 | 0 | 3 |
| HSD17B11 | ZNF703 | 0.758663 | 3 | 0 | 3 |
| HSD17B11 | HVCN1 | 0.757781 | 3 | 0 | 3 |
| HSD17B11 | DYRK2 | 0.755919 | 3 | 0 | 3 |
| HSD17B11 | PSMD1 | 0.747762 | 3 | 0 | 3 |
| HSD17B11 | POLR2G | 0.746208 | 3 | 0 | 3 |
| HSD17B11 | GTPBP6 | 0.735807 | 3 | 0 | 3 |
| HSD17B11 | ZNF805 | 0.727602 | 3 | 0 | 3 |
| HSD17B11 | DUS3L | 0.723639 | 3 | 0 | 3 |
| HSD17B11 | SORL1 | 0.722585 | 4 | 0 | 4 |
| HSD17B11 | MRPL47 | 0.718106 | 3 | 0 | 3 |
| HSD17B11 | ARL2 | 0.716924 | 4 | 0 | 4 |
| HSD17B11 | EFTUD2 | 0.716093 | 3 | 0 | 3 |
| HSD17B11 | BATF3 | 0.715081 | 3 | 0 | 3 |
| HSD17B11 | RBM18 | 0.712045 | 4 | 0 | 3 |
| HSD17B11 | TACO1 | 0.707174 | 3 | 0 | 3 |
| HSD17B11 | PSMC1 | 0.706077 | 3 | 0 | 3 |
| HSD17B11 | ARHGAP42 | 0.703044 | 3 | 0 | 3 |
For details and further investigation, click here
