| Full name: hydroxysteroid 17-beta dehydrogenase 7 | Alias Symbol: PRAP|SDR37C1 | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 51478 | HGNC ID: HGNC:5215 | Ensembl Gene: ENSG00000132196 | OMIM ID: 606756 |
| Drug and gene relationship at DGIdb | |||
HSD17B7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04913 | Ovarian steroidogenesis |
Expression of HSD17B7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD17B7 | 51478 | 220081_x_at | -0.0174 | 0.9828 | |
| GSE20347 | HSD17B7 | 51478 | 220081_x_at | 0.2863 | 0.0385 | |
| GSE23400 | HSD17B7 | 51478 | 220081_x_at | 0.1428 | 0.0086 | |
| GSE26886 | HSD17B7 | 51478 | 220081_x_at | 0.4881 | 0.0096 | |
| GSE29001 | HSD17B7 | 51478 | 220081_x_at | 0.0046 | 0.9841 | |
| GSE38129 | HSD17B7 | 51478 | 220081_x_at | 0.2828 | 0.0164 | |
| GSE45670 | HSD17B7 | 51478 | 220081_x_at | 0.1142 | 0.4119 | |
| GSE53622 | HSD17B7 | 51478 | 79815 | 0.2731 | 0.0020 | |
| GSE53624 | HSD17B7 | 51478 | 79815 | 0.0377 | 0.6785 | |
| GSE63941 | HSD17B7 | 51478 | 220081_x_at | 0.4341 | 0.2677 | |
| GSE77861 | HSD17B7 | 51478 | 220081_x_at | 0.1662 | 0.5847 | |
| GSE97050 | HSD17B7 | 51478 | A_33_P3276369 | 0.1825 | 0.5582 | |
| SRP007169 | HSD17B7 | 51478 | RNAseq | -0.4992 | 0.1976 | |
| SRP008496 | HSD17B7 | 51478 | RNAseq | -0.3613 | 0.1857 | |
| SRP064894 | HSD17B7 | 51478 | RNAseq | 0.1574 | 0.3399 | |
| SRP133303 | HSD17B7 | 51478 | RNAseq | 0.1844 | 0.4510 | |
| SRP159526 | HSD17B7 | 51478 | RNAseq | 0.4113 | 0.1778 | |
| SRP193095 | HSD17B7 | 51478 | RNAseq | -0.1979 | 0.0732 | |
| SRP219564 | HSD17B7 | 51478 | RNAseq | -0.2241 | 0.5433 | |
| TCGA | HSD17B7 | 51478 | RNAseq | 0.1810 | 0.0277 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HSD17B7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD17B7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD17B7 | 51478 | 10 | 0 | 20 | |
| GSE20123 | HSD17B7 | 51478 | 10 | 0 | 20 | |
| GSE43470 | HSD17B7 | 51478 | 7 | 2 | 34 | |
| GSE46452 | HSD17B7 | 51478 | 2 | 1 | 56 | |
| GSE47630 | HSD17B7 | 51478 | 14 | 0 | 26 | |
| GSE54993 | HSD17B7 | 51478 | 0 | 5 | 65 | |
| GSE54994 | HSD17B7 | 51478 | 16 | 0 | 37 | |
| GSE60625 | HSD17B7 | 51478 | 0 | 0 | 11 | |
| GSE74703 | HSD17B7 | 51478 | 7 | 2 | 27 | |
| GSE74704 | HSD17B7 | 51478 | 4 | 0 | 16 | |
| TCGA | HSD17B7 | 51478 | 42 | 4 | 50 |
Total number of gains: 112; Total number of losses: 14; Total Number of normals: 362.
Somatic mutations of HSD17B7:
Generating mutation plots.
Highly correlated genes for HSD17B7:
Showing top 20/180 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD17B7 | SSBP3-AS1 | 0.747724 | 3 | 0 | 3 |
| HSD17B7 | PPP6R2 | 0.730334 | 3 | 0 | 3 |
| HSD17B7 | FKBP2 | 0.727035 | 3 | 0 | 3 |
| HSD17B7 | EPHB1 | 0.726839 | 3 | 0 | 3 |
| HSD17B7 | RAMP2-AS1 | 0.717587 | 3 | 0 | 3 |
| HSD17B7 | SUPT7L | 0.712201 | 3 | 0 | 3 |
| HSD17B7 | CCDC84 | 0.708772 | 3 | 0 | 3 |
| HSD17B7 | PDCD4 | 0.707458 | 3 | 0 | 3 |
| HSD17B7 | ZNF75A | 0.707138 | 3 | 0 | 3 |
| HSD17B7 | MET | 0.706795 | 3 | 0 | 3 |
| HSD17B7 | SOD2 | 0.705307 | 3 | 0 | 3 |
| HSD17B7 | OCIAD1 | 0.698148 | 5 | 0 | 4 |
| HSD17B7 | ALKBH6 | 0.695677 | 3 | 0 | 3 |
| HSD17B7 | TCERG1 | 0.686801 | 3 | 0 | 3 |
| HSD17B7 | ZNF417 | 0.685055 | 3 | 0 | 3 |
| HSD17B7 | HSCB | 0.683613 | 5 | 0 | 4 |
| HSD17B7 | NLN | 0.681616 | 5 | 0 | 4 |
| HSD17B7 | DGCR8 | 0.677732 | 3 | 0 | 3 |
| HSD17B7 | ACACA | 0.677429 | 3 | 0 | 3 |
| HSD17B7 | GTF2F2 | 0.671318 | 3 | 0 | 3 |
For details and further investigation, click here
