| Full name: EPH receptor B1 | Alias Symbol: Hek6 | ||
| Type: protein-coding gene | Cytoband: 3q22.2 | ||
| Entrez ID: 2047 | HGNC ID: HGNC:3392 | Ensembl Gene: ENSG00000154928 | OMIM ID: 600600 |
| Drug and gene relationship at DGIdb | |||
EPHB1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of EPHB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPHB1 | 2047 | 210753_s_at | 0.5329 | 0.2778 | |
| GSE20347 | EPHB1 | 2047 | 210753_s_at | 0.3101 | 0.0204 | |
| GSE23400 | EPHB1 | 2047 | 210753_s_at | -0.0177 | 0.7492 | |
| GSE26886 | EPHB1 | 2047 | 210753_s_at | -0.0210 | 0.8682 | |
| GSE29001 | EPHB1 | 2047 | 210753_s_at | -0.0951 | 0.6431 | |
| GSE38129 | EPHB1 | 2047 | 210753_s_at | 0.2338 | 0.1441 | |
| GSE45670 | EPHB1 | 2047 | 210753_s_at | 0.4602 | 0.0642 | |
| GSE53622 | EPHB1 | 2047 | 42294 | 0.6140 | 0.0000 | |
| GSE53624 | EPHB1 | 2047 | 30382 | 1.4150 | 0.0000 | |
| GSE63941 | EPHB1 | 2047 | 210753_s_at | 0.3080 | 0.1902 | |
| GSE77861 | EPHB1 | 2047 | 210753_s_at | 0.0916 | 0.4539 | |
| GSE97050 | EPHB1 | 2047 | A_23_P166993 | 0.4679 | 0.2290 | |
| SRP064894 | EPHB1 | 2047 | RNAseq | 1.5796 | 0.0002 | |
| SRP133303 | EPHB1 | 2047 | RNAseq | 1.0946 | 0.0165 | |
| SRP159526 | EPHB1 | 2047 | RNAseq | 3.2961 | 0.0000 | |
| TCGA | EPHB1 | 2047 | RNAseq | 0.3585 | 0.3166 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by EPHB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPHB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPHB1 | 2047 | 16 | 0 | 14 | |
| GSE20123 | EPHB1 | 2047 | 16 | 0 | 14 | |
| GSE43470 | EPHB1 | 2047 | 21 | 0 | 22 | |
| GSE46452 | EPHB1 | 2047 | 15 | 4 | 40 | |
| GSE47630 | EPHB1 | 2047 | 18 | 3 | 19 | |
| GSE54993 | EPHB1 | 2047 | 2 | 8 | 60 | |
| GSE54994 | EPHB1 | 2047 | 32 | 1 | 20 | |
| GSE60625 | EPHB1 | 2047 | 0 | 6 | 5 | |
| GSE74703 | EPHB1 | 2047 | 18 | 0 | 18 | |
| GSE74704 | EPHB1 | 2047 | 11 | 0 | 9 | |
| TCGA | EPHB1 | 2047 | 59 | 5 | 32 |
Total number of gains: 208; Total number of losses: 27; Total Number of normals: 253.
Somatic mutations of EPHB1:
Generating mutation plots.
Highly correlated genes for EPHB1:
Showing top 20/425 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPHB1 | CD19 | 0.74301 | 4 | 0 | 4 |
| EPHB1 | HSD17B7 | 0.726839 | 3 | 0 | 3 |
| EPHB1 | ALG1 | 0.694543 | 3 | 0 | 3 |
| EPHB1 | CYP3A4 | 0.691915 | 3 | 0 | 3 |
| EPHB1 | ATXN7L3 | 0.691835 | 3 | 0 | 3 |
| EPHB1 | CDC14A | 0.68414 | 3 | 0 | 3 |
| EPHB1 | GTPBP3 | 0.683288 | 3 | 0 | 3 |
| EPHB1 | ZAP70 | 0.681138 | 3 | 0 | 3 |
| EPHB1 | TIGIT | 0.681019 | 3 | 0 | 3 |
| EPHB1 | CHST5 | 0.678738 | 4 | 0 | 4 |
| EPHB1 | CYSLTR2 | 0.673173 | 5 | 0 | 5 |
| EPHB1 | SPICE1 | 0.671295 | 3 | 0 | 3 |
| EPHB1 | STRADA | 0.665131 | 4 | 0 | 3 |
| EPHB1 | RNF166 | 0.664737 | 3 | 0 | 3 |
| EPHB1 | IKZF3 | 0.660641 | 5 | 0 | 4 |
| EPHB1 | ANKRD54 | 0.658643 | 3 | 0 | 3 |
| EPHB1 | KHDRBS2 | 0.657124 | 3 | 0 | 3 |
| EPHB1 | PPP5C | 0.656191 | 5 | 0 | 5 |
| EPHB1 | SOAT2 | 0.655423 | 3 | 0 | 3 |
| EPHB1 | RNF185-AS1 | 0.654501 | 3 | 0 | 3 |
For details and further investigation, click here
