| Full name: acetyl-CoA carboxylase alpha | Alias Symbol: ACC1 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 31 | HGNC ID: HGNC:84 | Ensembl Gene: ENSG00000278540 | OMIM ID: 200350 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ACACA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway | |
| hsa04910 | Insulin signaling pathway | |
| hsa04922 | Glucagon signaling pathway |
Expression of ACACA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACACA | 31 | 212186_at | 0.6396 | 0.0201 | |
| GSE20347 | ACACA | 31 | 212186_at | 0.0987 | 0.4144 | |
| GSE23400 | ACACA | 31 | 212186_at | 0.1352 | 0.0231 | |
| GSE26886 | ACACA | 31 | 212186_at | -0.0534 | 0.7527 | |
| GSE29001 | ACACA | 31 | 212186_at | 0.0396 | 0.8563 | |
| GSE38129 | ACACA | 31 | 212186_at | 0.1525 | 0.1486 | |
| GSE45670 | ACACA | 31 | 212186_at | 0.3848 | 0.0010 | |
| GSE53622 | ACACA | 31 | 79560 | -0.0180 | 0.8608 | |
| GSE53624 | ACACA | 31 | 79560 | 0.1147 | 0.0723 | |
| GSE63941 | ACACA | 31 | 212186_at | 0.8428 | 0.0077 | |
| GSE77861 | ACACA | 31 | 212186_at | 0.4120 | 0.0636 | |
| GSE97050 | ACACA | 31 | A_33_P3334225 | 0.0059 | 0.9878 | |
| SRP007169 | ACACA | 31 | RNAseq | 0.9399 | 0.0040 | |
| SRP008496 | ACACA | 31 | RNAseq | 0.6040 | 0.0202 | |
| SRP064894 | ACACA | 31 | RNAseq | -0.1293 | 0.4780 | |
| SRP133303 | ACACA | 31 | RNAseq | 0.1639 | 0.3691 | |
| SRP159526 | ACACA | 31 | RNAseq | -0.0272 | 0.9190 | |
| SRP193095 | ACACA | 31 | RNAseq | 0.0803 | 0.5634 | |
| SRP219564 | ACACA | 31 | RNAseq | -0.3321 | 0.3730 | |
| TCGA | ACACA | 31 | RNAseq | 0.1021 | 0.0672 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ACACA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACACA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACACA | 31 | 6 | 1 | 23 | |
| GSE20123 | ACACA | 31 | 6 | 1 | 23 | |
| GSE43470 | ACACA | 31 | 1 | 2 | 40 | |
| GSE46452 | ACACA | 31 | 35 | 0 | 24 | |
| GSE47630 | ACACA | 31 | 8 | 1 | 31 | |
| GSE54993 | ACACA | 31 | 3 | 3 | 64 | |
| GSE54994 | ACACA | 31 | 9 | 5 | 39 | |
| GSE60625 | ACACA | 31 | 4 | 0 | 7 | |
| GSE74703 | ACACA | 31 | 1 | 1 | 34 | |
| GSE74704 | ACACA | 31 | 3 | 1 | 16 | |
| TCGA | ACACA | 31 | 20 | 9 | 67 |
Total number of gains: 96; Total number of losses: 24; Total Number of normals: 368.
Somatic mutations of ACACA:
Generating mutation plots.
Highly correlated genes for ACACA:
Showing top 20/590 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACACA | CHML | 0.805203 | 3 | 0 | 3 |
| ACACA | C17orf80 | 0.804315 | 3 | 0 | 3 |
| ACACA | TRMT6 | 0.796637 | 3 | 0 | 3 |
| ACACA | IWS1 | 0.784885 | 3 | 0 | 3 |
| ACACA | DHX35 | 0.781387 | 3 | 0 | 3 |
| ACACA | MSH2 | 0.773864 | 3 | 0 | 3 |
| ACACA | FAM161A | 0.771828 | 3 | 0 | 3 |
| ACACA | UCKL1 | 0.770474 | 3 | 0 | 3 |
| ACACA | SEMA4C | 0.769426 | 3 | 0 | 3 |
| ACACA | SLC41A1 | 0.769 | 3 | 0 | 3 |
| ACACA | CAMSAP2 | 0.765522 | 3 | 0 | 3 |
| ACACA | PET117 | 0.76434 | 3 | 0 | 3 |
| ACACA | C12orf65 | 0.761192 | 3 | 0 | 3 |
| ACACA | LPGAT1 | 0.758692 | 3 | 0 | 3 |
| ACACA | RBM15 | 0.754864 | 3 | 0 | 3 |
| ACACA | SLC7A6 | 0.746703 | 3 | 0 | 3 |
| ACACA | TRUB1 | 0.745341 | 3 | 0 | 3 |
| ACACA | ATP13A3 | 0.740193 | 3 | 0 | 3 |
| ACACA | PSMB4 | 0.735784 | 3 | 0 | 3 |
| ACACA | PLAGL2 | 0.734511 | 4 | 0 | 3 |
For details and further investigation, click here
