| Full name: heat shock protein family B (small) member 8 | Alias Symbol: H11|E2IG1|HSP22|HspB8|CMT2L | ||
| Type: protein-coding gene | Cytoband: 12q24.23 | ||
| Entrez ID: 26353 | HGNC ID: HGNC:30171 | Ensembl Gene: ENSG00000152137 | OMIM ID: 608014 |
| Drug and gene relationship at DGIdb | |||
Expression of HSPB8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSPB8 | 26353 | 221667_s_at | -2.1680 | 0.0221 | |
| GSE20347 | HSPB8 | 26353 | 221667_s_at | -2.3832 | 0.0000 | |
| GSE23400 | HSPB8 | 26353 | 221667_s_at | -1.8715 | 0.0000 | |
| GSE26886 | HSPB8 | 26353 | 221667_s_at | -3.7220 | 0.0000 | |
| GSE29001 | HSPB8 | 26353 | 221667_s_at | -2.3156 | 0.0004 | |
| GSE38129 | HSPB8 | 26353 | 221667_s_at | -2.6240 | 0.0000 | |
| GSE45670 | HSPB8 | 26353 | 221667_s_at | -1.3502 | 0.0211 | |
| GSE53622 | HSPB8 | 26353 | 39578 | -2.3988 | 0.0000 | |
| GSE53624 | HSPB8 | 26353 | 39578 | -2.4983 | 0.0000 | |
| GSE63941 | HSPB8 | 26353 | 221667_s_at | -2.3821 | 0.0859 | |
| GSE77861 | HSPB8 | 26353 | 221667_s_at | -1.9321 | 0.0045 | |
| GSE97050 | HSPB8 | 26353 | A_23_P162579 | -1.5968 | 0.1403 | |
| SRP008496 | HSPB8 | 26353 | RNAseq | -3.9324 | 0.0000 | |
| SRP064894 | HSPB8 | 26353 | RNAseq | -1.9088 | 0.0000 | |
| SRP133303 | HSPB8 | 26353 | RNAseq | -1.5677 | 0.0025 | |
| SRP159526 | HSPB8 | 26353 | RNAseq | -2.4980 | 0.0000 | |
| SRP193095 | HSPB8 | 26353 | RNAseq | -2.1357 | 0.0000 | |
| SRP219564 | HSPB8 | 26353 | RNAseq | -1.7268 | 0.0107 | |
| TCGA | HSPB8 | 26353 | RNAseq | -0.4571 | 0.0103 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by HSPB8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSPB8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSPB8 | 26353 | 6 | 2 | 22 | |
| GSE20123 | HSPB8 | 26353 | 6 | 2 | 22 | |
| GSE43470 | HSPB8 | 26353 | 2 | 2 | 39 | |
| GSE46452 | HSPB8 | 26353 | 9 | 1 | 49 | |
| GSE47630 | HSPB8 | 26353 | 9 | 3 | 28 | |
| GSE54993 | HSPB8 | 26353 | 0 | 5 | 65 | |
| GSE54994 | HSPB8 | 26353 | 6 | 6 | 41 | |
| GSE60625 | HSPB8 | 26353 | 0 | 0 | 11 | |
| GSE74703 | HSPB8 | 26353 | 2 | 1 | 33 | |
| GSE74704 | HSPB8 | 26353 | 3 | 2 | 15 | |
| TCGA | HSPB8 | 26353 | 21 | 11 | 64 |
Total number of gains: 64; Total number of losses: 35; Total Number of normals: 389.
Somatic mutations of HSPB8:
Generating mutation plots.
Highly correlated genes for HSPB8:
Showing top 20/1495 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSPB8 | MYZAP | 0.865484 | 3 | 0 | 3 |
| HSPB8 | RBFOX3 | 0.855594 | 3 | 0 | 3 |
| HSPB8 | SNORA68 | 0.799894 | 4 | 0 | 4 |
| HSPB8 | SHROOM3 | 0.797764 | 7 | 0 | 7 |
| HSPB8 | KIAA0232 | 0.794064 | 11 | 0 | 11 |
| HSPB8 | KIAA1211L | 0.785895 | 6 | 0 | 6 |
| HSPB8 | ARHGAP10 | 0.783137 | 12 | 0 | 12 |
| HSPB8 | FAM214A | 0.782886 | 6 | 0 | 6 |
| HSPB8 | CRISP3 | 0.77695 | 10 | 0 | 10 |
| HSPB8 | C5orf66-AS1 | 0.776026 | 6 | 0 | 6 |
| HSPB8 | SH3BGRL2 | 0.775645 | 7 | 0 | 6 |
| HSPB8 | TMPRSS11B | 0.775471 | 6 | 0 | 6 |
| HSPB8 | SORBS2 | 0.773518 | 11 | 0 | 11 |
| HSPB8 | PCBP1-AS1 | 0.773352 | 4 | 0 | 4 |
| HSPB8 | PPP1R3C | 0.772877 | 13 | 0 | 12 |
| HSPB8 | SORCS1 | 0.770249 | 4 | 0 | 4 |
| HSPB8 | CYP21A2 | 0.766999 | 3 | 0 | 3 |
| HSPB8 | TP53INP2 | 0.766609 | 8 | 0 | 7 |
| HSPB8 | CGNL1 | 0.766183 | 7 | 0 | 7 |
| HSPB8 | ANKRD22 | 0.765889 | 3 | 0 | 3 |
For details and further investigation, click here
