| Full name: protein phosphatase 1 regulatory subunit 3C | Alias Symbol: PTG | ||
| Type: protein-coding gene | Cytoband: 10q23.32 | ||
| Entrez ID: 5507 | HGNC ID: HGNC:9293 | Ensembl Gene: ENSG00000119938 | OMIM ID: 602999 |
| Drug and gene relationship at DGIdb | |||
PPP1R3C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04910 | Insulin signaling pathway | |
| hsa04931 | Insulin resistance |
Expression of PPP1R3C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R3C | 5507 | 204284_at | -4.0728 | 0.0260 | |
| GSE20347 | PPP1R3C | 5507 | 204284_at | -4.0151 | 0.0000 | |
| GSE23400 | PPP1R3C | 5507 | 204284_at | -3.2320 | 0.0000 | |
| GSE26886 | PPP1R3C | 5507 | 204284_at | -5.9805 | 0.0000 | |
| GSE29001 | PPP1R3C | 5507 | 204284_at | -3.8035 | 0.0000 | |
| GSE38129 | PPP1R3C | 5507 | 204284_at | -3.5584 | 0.0000 | |
| GSE45670 | PPP1R3C | 5507 | 204284_at | -1.2707 | 0.1890 | |
| GSE53622 | PPP1R3C | 5507 | 14019 | -4.2303 | 0.0000 | |
| GSE53624 | PPP1R3C | 5507 | 14019 | -4.2121 | 0.0000 | |
| GSE63941 | PPP1R3C | 5507 | 204284_at | -6.6687 | 0.0002 | |
| GSE77861 | PPP1R3C | 5507 | 204284_at | -3.3105 | 0.0007 | |
| GSE97050 | PPP1R3C | 5507 | A_23_P35414 | -2.6682 | 0.0620 | |
| SRP007169 | PPP1R3C | 5507 | RNAseq | -7.1865 | 0.0000 | |
| SRP008496 | PPP1R3C | 5507 | RNAseq | -6.4780 | 0.0000 | |
| SRP064894 | PPP1R3C | 5507 | RNAseq | -4.1062 | 0.0000 | |
| SRP133303 | PPP1R3C | 5507 | RNAseq | -2.6859 | 0.0004 | |
| SRP159526 | PPP1R3C | 5507 | RNAseq | -4.7658 | 0.0000 | |
| SRP193095 | PPP1R3C | 5507 | RNAseq | -4.4161 | 0.0000 | |
| SRP219564 | PPP1R3C | 5507 | RNAseq | -3.0186 | 0.0032 | |
| TCGA | PPP1R3C | 5507 | RNAseq | -0.9185 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 17.
Survival by PPP1R3C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R3C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R3C | 5507 | 1 | 7 | 22 | |
| GSE20123 | PPP1R3C | 5507 | 1 | 6 | 23 | |
| GSE43470 | PPP1R3C | 5507 | 0 | 8 | 35 | |
| GSE46452 | PPP1R3C | 5507 | 0 | 11 | 48 | |
| GSE47630 | PPP1R3C | 5507 | 2 | 14 | 24 | |
| GSE54993 | PPP1R3C | 5507 | 7 | 0 | 63 | |
| GSE54994 | PPP1R3C | 5507 | 1 | 10 | 42 | |
| GSE60625 | PPP1R3C | 5507 | 0 | 0 | 11 | |
| GSE74703 | PPP1R3C | 5507 | 0 | 6 | 30 | |
| GSE74704 | PPP1R3C | 5507 | 0 | 4 | 16 | |
| TCGA | PPP1R3C | 5507 | 7 | 27 | 62 |
Total number of gains: 19; Total number of losses: 93; Total Number of normals: 376.
Somatic mutations of PPP1R3C:
Generating mutation plots.
Highly correlated genes for PPP1R3C:
Showing top 20/1678 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R3C | CYSRT1 | 0.898561 | 6 | 0 | 6 |
| PPP1R3C | VSIG10L | 0.871459 | 6 | 0 | 6 |
| PPP1R3C | RAET1E | 0.868073 | 6 | 0 | 6 |
| PPP1R3C | SPINK7 | 0.858648 | 7 | 0 | 7 |
| PPP1R3C | CRNN | 0.858158 | 11 | 0 | 11 |
| PPP1R3C | MGLL | 0.856644 | 12 | 0 | 12 |
| PPP1R3C | GDPD3 | 0.8544 | 10 | 0 | 10 |
| PPP1R3C | SLURP1 | 0.849876 | 11 | 0 | 11 |
| PPP1R3C | CRISP3 | 0.846115 | 11 | 0 | 11 |
| PPP1R3C | ABLIM3 | 0.844049 | 11 | 0 | 11 |
| PPP1R3C | SH3BGRL2 | 0.843679 | 7 | 0 | 7 |
| PPP1R3C | SPAG17 | 0.842557 | 4 | 0 | 4 |
| PPP1R3C | GYS2 | 0.841628 | 10 | 0 | 10 |
| PPP1R3C | CAPN14 | 0.840851 | 7 | 0 | 7 |
| PPP1R3C | MYZAP | 0.840667 | 3 | 0 | 3 |
| PPP1R3C | CLCA4 | 0.840159 | 11 | 0 | 11 |
| PPP1R3C | ANKRD35 | 0.832686 | 8 | 0 | 8 |
| PPP1R3C | KRT78 | 0.83139 | 8 | 0 | 8 |
| PPP1R3C | ECM1 | 0.829331 | 12 | 0 | 12 |
| PPP1R3C | UBL3 | 0.828893 | 11 | 0 | 10 |
For details and further investigation, click here
