| Full name: shroom family member 3 | Alias Symbol: ShrmL|SHRM|KIAA1481|APXL3 | ||
| Type: protein-coding gene | Cytoband: 4q21.1 | ||
| Entrez ID: 57619 | HGNC ID: HGNC:30422 | Ensembl Gene: ENSG00000138771 | OMIM ID: 604570 |
| Drug and gene relationship at DGIdb | |||
SHROOM3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of SHROOM3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHROOM3 | 57619 | 225548_at | -1.9098 | 0.0253 | |
| GSE26886 | SHROOM3 | 57619 | 225548_at | -3.0118 | 0.0000 | |
| GSE45670 | SHROOM3 | 57619 | 228400_at | -1.3316 | 0.0037 | |
| GSE53622 | SHROOM3 | 57619 | 17934 | -2.8506 | 0.0000 | |
| GSE53624 | SHROOM3 | 57619 | 55890 | -2.9590 | 0.0000 | |
| GSE63941 | SHROOM3 | 57619 | 228400_at | 0.0526 | 0.9536 | |
| GSE77861 | SHROOM3 | 57619 | 225548_at | -1.6575 | 0.0006 | |
| GSE97050 | SHROOM3 | 57619 | A_33_P3417339 | -1.1219 | 0.1839 | |
| SRP007169 | SHROOM3 | 57619 | RNAseq | -3.5005 | 0.0000 | |
| SRP008496 | SHROOM3 | 57619 | RNAseq | -3.7268 | 0.0000 | |
| SRP064894 | SHROOM3 | 57619 | RNAseq | -3.3002 | 0.0000 | |
| SRP133303 | SHROOM3 | 57619 | RNAseq | -2.0974 | 0.0000 | |
| SRP159526 | SHROOM3 | 57619 | RNAseq | -2.6042 | 0.0000 | |
| SRP193095 | SHROOM3 | 57619 | RNAseq | -1.8973 | 0.0000 | |
| SRP219564 | SHROOM3 | 57619 | RNAseq | -2.1199 | 0.0000 | |
| TCGA | SHROOM3 | 57619 | RNAseq | -0.8916 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by SHROOM3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHROOM3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHROOM3 | 57619 | 3 | 9 | 18 | |
| GSE20123 | SHROOM3 | 57619 | 3 | 9 | 18 | |
| GSE43470 | SHROOM3 | 57619 | 0 | 13 | 30 | |
| GSE46452 | SHROOM3 | 57619 | 1 | 36 | 22 | |
| GSE47630 | SHROOM3 | 57619 | 1 | 19 | 20 | |
| GSE54993 | SHROOM3 | 57619 | 7 | 0 | 63 | |
| GSE54994 | SHROOM3 | 57619 | 0 | 9 | 44 | |
| GSE60625 | SHROOM3 | 57619 | 0 | 0 | 11 | |
| GSE74703 | SHROOM3 | 57619 | 0 | 11 | 25 | |
| GSE74704 | SHROOM3 | 57619 | 2 | 5 | 13 | |
| TCGA | SHROOM3 | 57619 | 18 | 30 | 48 |
Total number of gains: 35; Total number of losses: 141; Total Number of normals: 312.
Somatic mutations of SHROOM3:
Generating mutation plots.
Highly correlated genes for SHROOM3:
Showing top 20/1700 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHROOM3 | CAB39L | 0.864972 | 7 | 0 | 7 |
| SHROOM3 | EMP1 | 0.846527 | 6 | 0 | 6 |
| SHROOM3 | CAPN5 | 0.844229 | 7 | 0 | 7 |
| SHROOM3 | FAM214A | 0.84243 | 6 | 0 | 6 |
| SHROOM3 | PADI1 | 0.836999 | 4 | 0 | 4 |
| SHROOM3 | FAM3D | 0.83468 | 6 | 0 | 6 |
| SHROOM3 | SIM2 | 0.830769 | 7 | 0 | 7 |
| SHROOM3 | KAT2B | 0.828268 | 7 | 0 | 7 |
| SHROOM3 | CRISP3 | 0.827908 | 6 | 0 | 6 |
| SHROOM3 | HPGD | 0.823654 | 7 | 0 | 7 |
| SHROOM3 | SORT1 | 0.823431 | 7 | 0 | 7 |
| SHROOM3 | PPP1R3C | 0.822917 | 7 | 0 | 7 |
| SHROOM3 | SNORA68 | 0.821835 | 4 | 0 | 4 |
| SHROOM3 | LMBRD1 | 0.819167 | 7 | 0 | 7 |
| SHROOM3 | MAL | 0.818976 | 6 | 0 | 6 |
| SHROOM3 | GYS2 | 0.81806 | 6 | 0 | 6 |
| SHROOM3 | MYZAP | 0.810277 | 3 | 0 | 3 |
| SHROOM3 | FAM3B | 0.809759 | 6 | 0 | 6 |
| SHROOM3 | ECHDC2 | 0.808757 | 7 | 0 | 7 |
| SHROOM3 | SECISBP2L | 0.807191 | 7 | 0 | 7 |
For details and further investigation, click here
