| Full name: 5-hydroxytryptamine receptor 1E | Alias Symbol: 5-HT1E | ||
| Type: protein-coding gene | Cytoband: 6q14.3 | ||
| Entrez ID: 3354 | HGNC ID: HGNC:5291 | Ensembl Gene: ENSG00000168830 | OMIM ID: 182132 |
| Drug and gene relationship at DGIdb | |||
HTR1E involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04726 | Serotonergic synapse | |
| hsa04742 | Taste transduction |
Expression of HTR1E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTR1E | 3354 | 207404_s_at | -0.1542 | 0.5589 | |
| GSE20347 | HTR1E | 3354 | 207404_s_at | -0.0286 | 0.7104 | |
| GSE23400 | HTR1E | 3354 | 207404_s_at | -0.1499 | 0.0016 | |
| GSE26886 | HTR1E | 3354 | 207404_s_at | -0.5488 | 0.0026 | |
| GSE29001 | HTR1E | 3354 | 207404_s_at | -0.1776 | 0.3161 | |
| GSE38129 | HTR1E | 3354 | 207404_s_at | -0.1360 | 0.1316 | |
| GSE45670 | HTR1E | 3354 | 207404_s_at | -0.0244 | 0.8456 | |
| GSE53622 | HTR1E | 3354 | 46330 | -0.5130 | 0.0026 | |
| GSE53624 | HTR1E | 3354 | 46330 | -1.8914 | 0.0000 | |
| GSE63941 | HTR1E | 3354 | 207404_s_at | -0.0594 | 0.7300 | |
| GSE77861 | HTR1E | 3354 | 207404_s_at | -0.2525 | 0.0413 | |
| TCGA | HTR1E | 3354 | RNAseq | -6.1584 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by HTR1E expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTR1E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTR1E | 3354 | 1 | 4 | 25 | |
| GSE20123 | HTR1E | 3354 | 1 | 3 | 26 | |
| GSE43470 | HTR1E | 3354 | 2 | 1 | 40 | |
| GSE46452 | HTR1E | 3354 | 2 | 11 | 46 | |
| GSE47630 | HTR1E | 3354 | 8 | 6 | 26 | |
| GSE54993 | HTR1E | 3354 | 3 | 2 | 65 | |
| GSE54994 | HTR1E | 3354 | 8 | 8 | 37 | |
| GSE60625 | HTR1E | 3354 | 0 | 1 | 10 | |
| GSE74703 | HTR1E | 3354 | 2 | 1 | 33 | |
| GSE74704 | HTR1E | 3354 | 0 | 2 | 18 | |
| TCGA | HTR1E | 3354 | 5 | 21 | 70 |
Total number of gains: 32; Total number of losses: 60; Total Number of normals: 396.
Somatic mutations of HTR1E:
Generating mutation plots.
Highly correlated genes for HTR1E:
Showing top 20/1012 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTR1E | MUC5AC | 0.706485 | 6 | 0 | 6 |
| HTR1E | WNK2 | 0.701413 | 3 | 0 | 3 |
| HTR1E | ITGA10 | 0.698252 | 5 | 0 | 4 |
| HTR1E | FRAS1 | 0.68996 | 5 | 0 | 5 |
| HTR1E | PHF7 | 0.689189 | 6 | 0 | 6 |
| HTR1E | SPATA25 | 0.686176 | 3 | 0 | 3 |
| HTR1E | PTPN5 | 0.684928 | 3 | 0 | 3 |
| HTR1E | CIITA | 0.683847 | 5 | 0 | 5 |
| HTR1E | CGA | 0.675555 | 4 | 0 | 4 |
| HTR1E | IFNA17 | 0.674289 | 6 | 0 | 5 |
| HTR1E | CNR2 | 0.672588 | 8 | 0 | 8 |
| HTR1E | XPNPEP2 | 0.67231 | 4 | 0 | 3 |
| HTR1E | PRSS33 | 0.671347 | 3 | 0 | 3 |
| HTR1E | SLC10A1 | 0.670781 | 5 | 0 | 5 |
| HTR1E | SPTBN4 | 0.669998 | 4 | 0 | 3 |
| HTR1E | USH1C | 0.669165 | 7 | 0 | 6 |
| HTR1E | KIF9-AS1 | 0.666358 | 3 | 0 | 3 |
| HTR1E | OVGP1 | 0.664814 | 6 | 0 | 5 |
| HTR1E | C1QL1 | 0.664013 | 3 | 0 | 3 |
| HTR1E | SNAP91 | 0.663853 | 5 | 0 | 5 |
For details and further investigation, click here
